Development of functional surfaces on metallic materials via design of (bio)molecular and metal oxide surface layers

通过（生物）分子和金属氧化物表面层的设计开发金属材料的功能表面

• 批准号: 249588-2011
• 负责人: Omanovic, Sasha
• 金额: $ 2.19万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=570654
• 关键词: Development; functional; surfaces; metallic; materials

Functional materials/surfaces play a major role in today's world, ranging from simple consumer products, such as anti-bacterial surfaces (e.g. bandages) to energy production (e.g. photoanodes) to medical applications (e.g. drug-eluting coronary stents). Although bulk-material properties need to be considered when designing new equipment/devices, the actual functionality of the material (i.e. the device), in many cases depends predominantly on the interaction of its surface with the surrounding environment. Thus, functionalization of surfaces to achieve specific properties is of major importance for the development of many new technologies. This has been and continues to be the focus of my research program. The research program proposed in this grant application explores novel approaches for the design of functional surfaces. It will focus on (i) the design of new (bio)molecular and metal-oxide functional monolayers/coatings on model and commercial (industrial) metal/alloy surfaces for specific applications (e.g. coronary stents, neural stimulating and sensing electrodes, bone/dental implants, electrochemically-assisted drug-release systems), and on (ii) the determination of fundamental relationships between physicochemical, morphological and topographical properties of surfaces and their interaction with various environments (proteins, cells, bacteria, corrosive electrolytes and various (bio)organic molecules). While objective (i) is of direct practical significance, the knowledge gained by achieving objective (ii) will enable us to understand how various surface physicochemical properties (e.g. charge, wettability, chemical composition and reactivity), topography, structure of thin surface films and their electronic/dielectric and morphological properties control the interaction of the material's surface with its surroundings. This will, in turn, enable us and other researchers to base the design of surfaces for various applications on phenomena at the molecular/nano-level, rather than on empirical methods.

功能材料/表面在当今世界发挥着重要作用，从简单的消费品（例如抗菌表面（例如绷带））到能源生产（例如光阳极）再到医疗应用（例如药物洗脱冠状动脉支架）。尽管在设计新设备/装置时需要考虑散装材料的特性，但在许多情况下，材料（即装置）的实际功能主要取决于其表面与周围环境的相互作用。因此，表面功能化以获得特定性能对于许多新技术的开发至关重要。这一直是并将继续是我的研究计划的重点。 本拨款申请中提出的研究计划探索了功能表面设计的新方法。它将重点关注（i）针对特定应用（例如冠状动脉支架、神经刺激和传感电极、骨/牙科植入物、电化学辅助药物释放系统），以及（ii）确定表面的物理化学、形态和拓扑特性及其与各种环境（蛋白质、细胞、细菌、腐蚀性电解质和各种（生物）有机分子）。 虽然目标（i）具有直接的实际意义，但通过实现目标（ii）获得的知识将使我们能够了解各种表面物理化学性质（例如电荷，润湿性，化学成分和反应性），形貌，薄膜结构和它们的电子/介电和形态特性控制着材料表面与其周围环境的相互作用。反过来，这将使我们和其他研究人员能够根据分子/纳米水平的现象而不是经验方法来设计各种应用的表面。