Frequency domain mode locked novel dual core fiber laser for multichannel array based doppler optical coherence tomography

用于基于多通道阵列的多普勒光学相干断层扫描的频域锁模新型双芯光纤激光器

• 批准号: 355559-2009
• 负责人: Yang, Victor
• 金额: $ 2.04万
• 依托单位: Ryerson University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=527814
• 关键词: Frequency; domain; mode; locked; novel

Optical Coherence Tomography (OCT) is a new imaging modality that provides high resolution (near cellular level) suitable for real-time imaging and is becoming available for imaging the retina and other organs for neoplastic and vascular lesions. Doppler OCT (DOCT) adds blood flow imaging capability which is sensitive to slow blood flow in the microcirculation, and has been shown to detect neovasculature in pre-cancer and cancerous conditions. Recently there has been a growing interest in high power cladding pumped fiber lasers such as Yb doped fiber lasers, as a replacement for conventional lasers. Frequency domain mode locking of such fiber lasers may provide an optimal light source for DOCT at a wavelength range of 1027-1105 nm, optimal for imaging biological tissues. We will develop a low-cost and low-maintenance Yb doped fiber laser for multichannel array based DOCT, which could be extremely useful for guiding the next generation laser-based treatments, such as 2-photon photodynamic therapy, and provide a tightly controlled damage radius to preserve normal tissue.

光学相干断层扫描 (OCT) 是一种新的成像方式，可提供适合实时成像的高分辨率（接近细胞水平），并且可用于对视网膜和其他器官的肿瘤和血管病变进行成像。多普勒 OCT (DOCT) 增加了血流成像功能，该功能对微循环中的缓慢血流敏感，并且已被证明可以检测癌前和癌性疾病中的新生血管。 最近，人们对高功率包层泵浦光纤激光器（例如掺镱光纤激光器）作为传统激光器的替代品越来越感兴趣。 这种光纤激光器的频域锁模可以为 DOCT 提供波长范围为 1027-1105 nm 的最佳光源，最适合生物组织成像。 我们将开发一种低成本、低维护的掺镱光纤激光器，用于基于多通道阵列的 DOCT，这对于指导下一代基于激光的治疗（例如 2 光子光动力治疗）非常有用，并提供严格控制的损伤半径以保留正常组织。