Role of Gfi1 as a modulator of the ATM/DNA-PK DNA damage response pathway

Gfi1 作为 ATM/DNA-PK DNA 损伤反应途径调节剂的作用

• 批准号: 265650
• 负责人: Moroy Tarik
• 金额: $ 50万
• 依托单位: Institut de recherches cliniques de Montral
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-09-01 至 2017-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=265650&lang=en
• 关键词: Dna Damage Response; Leukemia; Programmed Cell Death; Signal Transduction; Transcription Factors; Transgenic And Knockout Mice; Dna Damage Response; Leukemia; Programmed Cell Death; Signal Transduction; Transcription Factors; Transgenic And Knockout Mice

When cells are subjected to gamma irradiation or certain chemotherapeutic drugs, the chromosomes and in particular the DNA within the chromosomes are damaged. As a consequence, the cells respond by stopping cell division to repair the damage. If the repai

当细胞受到γ辐射或某些化学治疗药物的影响时，染色体，尤其是染色体内的DNA受损。结果，细胞通过停止细胞分裂来修复损坏而做出响应。如果repai