Multi-scale mechanics of musculoskeletal tissues

肌肉骨骼组织的多尺度力学

• 批准号: 203436-2010
• 负责人: Duncan, Neil
• 金额: $ 2.33万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=510357
• 关键词: Multi; scale; mechanics; musculoskeletal; tissues

Degenerative disc disease, low back pain, osteoarthritis, osteoporosis, and repetitive loading syndromes are some of the most prevalent causes of morbidity in the Western world, and all predictions point to an increasing prevalence for the foreseeable future. The musculoskeletal system functions primarily to transmit mechanical loads, yet also has the remarkable ability of biological tissues to maintain and repair itself normally throughout life. This ability is attributable to the cells within the tissues, which all contain the essential information to direct the synthesis, assembly, and repair of the structural macromolecules in the extracellular matrix. Considerable evidence indicates that musculoskeletal tissues are well adapted to their biomechanical environment, and can adapt in response to changing mechanical demands. However, the mechanisms are poorly understood and there is a need to investigate more quantitatively and directly the in situ effect of complex and physiological mechanical loads on cell bio-synthesis.

退化性椎间盘疾病，腰痛，骨关节炎，骨质疏松症和重复负荷综合征是西方世界中发病率最普遍的一些原因，所有预测表明，在可预见的未来，人们的普遍性越来越高。肌肉骨骼系统的作用主要是传输机械载荷，但也具有生物组织正常维持和修复自身正常生命的能力。这种能力归因于组织中的细胞，这些能力都包含基本信息，以指导细胞外基质中结构大分子的合成，组装和修复。大量证据表明，肌肉骨骼组织非常适合其生物力学环境，并且可以适应机械需求的变化。但是，这些机制知之甚少，需要对复杂和生理机械负荷对细胞生物合成的复杂和生理载荷的原位作用进行更定量和原位作用。