Multi-scale mechanics of musculoskeletal tissues

肌肉骨骼组织的多尺度力学

• 批准号: 203436-2010
• 负责人: Duncan, Neil
• 金额: $ 2.33万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=510357
• 关键词: Multi; scale; mechanics; musculoskeletal; tissues

Degenerative disc disease, low back pain, osteoarthritis, osteoporosis, and repetitive loading syndromes are some of the most prevalent causes of morbidity in the Western world, and all predictions point to an increasing prevalence for the foreseeable future. The musculoskeletal system functions primarily to transmit mechanical loads, yet also has the remarkable ability of biological tissues to maintain and repair itself normally throughout life. This ability is attributable to the cells within the tissues, which all contain the essential information to direct the synthesis, assembly, and repair of the structural macromolecules in the extracellular matrix. Considerable evidence indicates that musculoskeletal tissues are well adapted to their biomechanical environment, and can adapt in response to changing mechanical demands. However, the mechanisms are poorly understood and there is a need to investigate more quantitatively and directly the in situ effect of complex and physiological mechanical loads on cell bio-synthesis.

退行性椎间盘疾病、腰痛、骨关节炎、骨质疏松症和重复性负荷综合症是西方世界最常见的发病原因，所有预测都表明在可预见的未来，患病率将不断增加。肌肉骨骼系统的主要功能是传递机械负荷，但也具有生物组织在整个生命过程中正常维持和修复自身的非凡能力。这种能力归因于组织内的细胞，它们都包含指导细胞外基质中结构大分子的合成、组装和修复的基本信息。大量证据表明，肌肉骨骼组织很好地适应了其生物力学环境，并且可以适应不断变化的机械需求。然而，人们对其机制知之甚少，需要更定量、更直接地研究复杂和生理机械负荷对细胞生物合成的原位影响。