Noninvasive fragmentation of urinary calculi with focused ultrasound bursts
聚焦超声脉冲无创碎裂泌尿系结石
基本信息
- 批准号:9069839
- 负责人:
- 金额:$ 13.7万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-06-01 至 2020-05-31
- 项目状态:已结题
- 来源:
- 关键词:AcousticsAdoptedAffectAreaAttentionBiomedical EngineeringCharacteristicsClinicalClinical TreatmentDataDevelopmentDevicesDiseaseExposure toFamily suidaeFeedbackFocused UltrasoundFocused Ultrasound TherapyFractureFrequenciesGenerationsGoalsHealthHealthcareHistologyIn VitroIndividualInjuryInjury to KidneyInstitutionInvestigationK-Series Research Career ProgramsKidneyKidney CalculiLaboratoriesLeadLithotripsyMeasurementMeasuresMechanicsMentorsMethodsModelingOutpatientsOutputPatientsPercutaneous NephrolithotomyPhysicsPhysiologic pulseProceduresResearchResearch PersonnelResourcesRetreatmentScienceShockSourceStagingStressSurfaceTechnologyTissuesTransducersTranslatingTreatment ProtocolsUltrasonic TherapyUltrasonic TransducerUltrasonographyUniversitiesUreteroscopyUrinary CalculiUrologyWashingtonWidthWorkbasecareer developmentcommon treatmentdesignexperienceimprovedin vivonovelnovel strategiespressureprototyperesearch and developmentresearch studystandard of caresuccesssystems researchtechnology developmenturolithiasisurologic
项目摘要
DESCRIPTION (provided by applicant): The candidate of the proposed Career Development Award is Dr. Adam Maxwell, a biomedical engineer with over 10 years of experience in medical ultrasound research, particularly shock wave lithotripsy and high- intensity focused ultrasound therapy. He has investigated physical interactions of acoustic waves with tissues, developed research and clinical prototype systems, and researched new applications for ultrasound therapies. The purpose of applying for this Career Development Award is for Dr. Maxwell to cultivate the qualities and abilities necessary to be a successful independent researcher and obtain expertise in urolithiasis under the guidance of three experienced mentors, Drs. Michael Bailey, Jonathan Harper, and Hunter Wessells. The University of Washington is a leading research institution at which Dr. Maxwell plans to pursue his research and career development. He will be supported by a collaborative team with expertise in stone management within the Department of Urology and medical ultrasound in the Center for Industrial and Medical Ultrasound at the Applied Physics Laboratory. His proposed research will investigate a potential new treatment for urolithiasis. Urolithiasis is a common disease that affects approximately 1 in 11 individuals during their lifetime and presents a large burden on U.S. healthcare resources. In the last 30 years, management of urinary tract stones has seen the introduction of several novel approaches, including shock wave lithotripsy (SWL), ureteroscopy, and percutaneous nephrolithotomy. SWL is the only noninvasive procedure for stones, but the likelihood of rendering patients stone-free in a single session is considerably lower than other methods, and has declined in newer lithotripters. Development of a more effective lithotripter remains an unmet clinical challenge. While the physical interactions between shocks and stones were not well understood during this technology's clinical introduction, recent research has established the mechanisms of stone fracture in SWL. Based on this work, a novel type of lithotripsy using widely focused bursts of ultrasound rather than shock waves is proposed. Preliminary data shows that burst wave lithotripsy (BWL) is capable of disintegrating stones in as little as 10 seconds. Furthermore, the size of fragments generated during the procedure can be controlled by the ultrasound frequency, potentiating a therapy that produces small fragments easily passed by patients. The goal of this proposal is to create a scientific rationale that will guide the development of burst wave lithotripsy. In particular, this project proposes to investigate the physical interactions of ultrasound bursts with stones and tissue, and use this information to determine therapy parameters. The specific aims of the proposal are: 1) Develop and characterize a suitable ultrasound source for BWL research, 2) Determine the mechanistic interactions leading to stone fracture by BWL, and 3) Identify the mechanical effects of BWL leading to tissue damage. Dr. Maxwell's long-term research goal is to translate this technology into a clinically useful treatment that improves the standard of care for stone management.
描述(由申请人提供):拟议职业发展奖的候选人是 Adam Maxwell 博士,他是一位生物医学工程师,在医学超声研究方面拥有 10 多年的经验,特别是冲击波碎石术和高强度聚焦超声治疗。声波与组织的物理相互作用,开发了研究和临床原型系统,并研究了超声疗法的新应用。麦克斯韦博士申请该职业发展奖的目的是培养成为一名成功的独立研究员所需的素质和能力。和在三位经验丰富的导师 Michael Bailey、Jonathan Harper 和 Hunter Wessells 博士的指导下获得尿石症方面的专业知识。麦克斯韦博士计划在华盛顿大学从事研究和职业发展。他提出的研究将研究一种常见的尿石症的潜在新疗法,该团队在泌尿外科和应用物理实验室工业和医学超声中心的医学超声方面具有专业知识。这种疾病影响大约十分之一的人一生,并且给美国医疗保健资源带来巨大负担。在过去 30 年中,尿路结石的治疗引入了多种新方法,包括冲击波碎石术 (SWL)、输尿管镜检查。和经皮肾镜碎石术是治疗结石的唯一非侵入性手术,但在一次治疗中使患者消除结石的可能性比其他方法低得多,并且在较新的方法中有所下降。开发更有效的碎石机仍然是一个尚未解决的临床挑战,虽然在这项技术的临床应用过程中冲击和结石之间的物理相互作用还没有得到很好的理解,但最近的研究已经建立了 SWL 中结石破裂的机制。提出了使用广泛聚焦的超声波碎石术而不是冲击波的新型碎石术。初步数据表明,突发波碎石术 (BWL) 能够在短短 10 秒内碎石。此外,手术过程中产生的碎片的大小可以通过超声波频率来控制,从而增强了产生易于被患者通过的小碎片的治疗方法。该提案的目标是创造一个科学原理来指导突发波碎石术的发展。特别是,该项目建议研究超声波爆发与结石和组织的物理相互作用,并利用这些信息来确定治疗参数。该建议的具体目标是:1)开发并表征适合 BWL 研究的超声源,2。 )确定 BWL 导致结石破裂的机械相互作用,以及 3) 确定 BWL 导致组织损伤的机械效应 Maxwell 博士的长期研究目标是将这项技术转化为临床上有用的治疗方法,以提高护理标准。石材管理。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(1)
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Adam Douglas Maxwell其他文献
Adam Douglas Maxwell的其他文献
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{{ truncateString('Adam Douglas Maxwell', 18)}}的其他基金
Noninvasive histotripsy ablation of fibrotic tissue in benign prostatic hyperplasia
良性前列腺增生纤维化组织的无创组织解剖消融
- 批准号:
10436315 - 财政年份:2019
- 资助金额:
$ 13.7万 - 项目类别:
Noninvasive histotripsy ablation of fibrotic tissue in benign prostatic hyperplasia
良性前列腺增生纤维化组织的无创组织解剖消融
- 批准号:
9815826 - 财政年份:2019
- 资助金额:
$ 13.7万 - 项目类别:
Noninvasive histotripsy ablation of fibrotic tissue in benign prostatic hyperplasia
良性前列腺增生纤维化组织的无创组织解剖消融
- 批准号:
10183239 - 财政年份:2019
- 资助金额:
$ 13.7万 - 项目类别:
Noninvasive histotripsy ablation of fibrotic tissue in benign prostatic hyperplasia
良性前列腺增生纤维化组织的无创组织解剖消融
- 批准号:
10005354 - 财政年份:2019
- 资助金额:
$ 13.7万 - 项目类别:
Noninvasive histotripsy ablation of fibrotic tissue in benign prostatic hyperplasia
良性前列腺增生纤维化组织的无创组织解剖消融
- 批准号:
10652668 - 财政年份:2019
- 资助金额:
$ 13.7万 - 项目类别:
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