K07 Leadership Grant

K07 领导力补助金

• 批准号: 9084463
• 负责人: SHARON K. INOUYE
• 金额: $ 13.06万
• 依托单位: HEBREW REHABILITATION CENTER FOR AGED
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9084463
• 关键词: Accounting; Acute; Address; Aging; American; Area; Award; Bibliography; Boston; Clinical; Clinical Investigator; Clinical Trials Design; Cognition Disorders; Collaborations; Communities; Confusion; Databases; Delirium; Developing Countries; Development; Diagnosis; Discipline; Educational process of instructing; Elderly; Expenditure; Family; Foundations; Geriatrics; Gerontology; Goals; Grant; Group Meetings; Health; Health Care Costs; Healthcare; Hospitals; Institution; Interdisciplinary Study; Interest Group; Intervention; Knowledge; Lead; Leadership; Libraries; Life; Medicare; Mentorship; Morbidity - disease rate; NCI Scholars Program; Outcome; Patients; Preventive Intervention; Program Development; Program Sustainability; Qualifying; Quality of life; Rehabilitation Centers; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Training; Resources; Risk Factors; Series; Statistical Methods; Syndrome; Technology; Time; Training; Training Programs; Training Support; Translating; Translational Research; Ursidae Family; Work; academic program; career development; clinical care; clinically relevant; cost; didactic education; experience; genomic biomarker; improved; innovation; institutional capacity; knowledge translation; longitudinal analysis; medical schools; meetings; mortality; neglect; neuroimaging; new technology; novel; outcome forecast; patient oriented research; prevent; programs; research and development; skills; special interest group; symposium; visiting scholar; web site; working group

DESCRIPTION (provided by applicant): Over 2.5 million older Americans develop delirium (acute confusional state) each year, a common and serious geriatric syndrome, with associated mortality rates of 25-33% and accounting for >$100 billion in healthcare expenditures in the ensuing year. Yet, less than 30% of these cases are recognized, and even fewer receive proven preventive interventions. Clinical care to address and prevent delirium is deficient both because empirical evidence is lacking and because existing evidence is not consistently translated in an effective manner. The Candidate, Dr. Inouye, is an expert geriatrician and experienced clinical investigator, who has conducted ground-breaking work to advance our understanding of the diagnosis, risk factors, prognosis, and interventions for delirium. For this K07 Leadership Award, she proposes to develop the nation's first program focusing specifically on delirium in older adults, the "Center of Excellence for Delirium in Aging: Research, Training and Educational Enhancement (CEDARTREE)" to advance delirium research and training. She will establish this program at Harvard Medical School-Hebrew Rehabilitation Center, bringing together world-renowned resources in clinical-translational research, geriatrics/gerontology, and superb interdisciplinary expertise and resources to support the program, which will stimulate research across the greater Boston academic community. The specific aims are to: 1) To create a comprehensive interdisciplinary training and mentorship program in delirium research, including a formal didactic curriculum, seminar series, collaborative working groups, and individualized mentorship with experienced investigators; 2) To develop core resources to attract interdisciplinary investigators to engage in collaborative delirium-related research (e.g., website research development grants, access to novel research technologies and databases, investigator listserve, statistical/methodological expertise, and delirium bibliography); and 3) To serve as a local and national resource for research on delirium in aging through disseminating website resources and educational content, hosting a visiting scholar program, annual scientific symposium, interest groups at national meetings, and developing national linkages to translate evidence. Innovative approaches will be incorporated at every level of the program: translational research on delirium (biomarkers, genomics, advanced neuroimaging), advanced statistical methods to address methodological challenges, and innovative educational strategies (e.g., interactive on-line educational approaches). For Dr. Inouye, the K07 award will provide the opportunity for further career development in key leadership areas and protect time needed to develop, fully implement, evaluate, refine, and establish the self-sustaining infrastructure to assure continuation of the center as an enduring contribution to aging research and training. CEDARTREE represents the first resource of its kind, providing an innovative and much-needed local/national resource and focal point that will enhance the capacity for research on delirium in aging, with the ultimate goal of improving health and quality of life for seniors.

描述（由申请人提供）：每年有超过 250 万美国老年人出现谵妄（急性精神错乱状态），这是一种常见且严重的老年综合症，相关死亡率为 25-33%，随后的医疗支出将超过 1000 亿美元年。然而，这些病例中只有不到 30% 得到认可，获得行之有效的预防干预措施的病例则更少。解决和预防谵妄的临床护理存在缺陷，这既是因为缺乏经验证据，也是因为现有证据没有始终如一地以有效的方式转化。候选人 Inouye 博士是一位老年病学专家和经验丰富的临床研究者，他进行了开创性的工作，以增进我们对谵妄的诊断、危险因素、预后和干预措施的理解。对于此次 K07 领导奖，她提议开发全国第一个专门针对老年人谵妄的项目，即“老年谵妄卓越中心：研究、培训和教育增强 (CEDARTREE)”，以推进谵妄研究和培训。她将在哈佛医学院希伯来康复中心建立该项目，汇集临床转化研究、老年病学/老年学方面的世界知名资源以及卓越的跨学科专业知识和资源来支持该项目，这将刺激整个波士顿学术界的研究社区。具体目标是： 1）在谵妄研究方面创建全面的跨学科培训和指导计划，包括正式的教学课程、研讨会系列、协作工作组以及经验丰富的研究人员的个性化指导； 2) 开发核心资源，吸引跨学科研究人员参与与谵妄相关的合作研究（例如，网站研究开发资助、获取新颖的研究技术和数据库、研究者列表服务、统计/方法学专业知识和谵妄参考书目）； 3) 至 通过传播网站资源和教育内容、主办访问学者计划、年度科学研讨会、参加国家会议的兴趣小组以及发展国家联系以翻译证据，作为老龄化谵妄研究的地方和国家资源。创新方法将纳入该计划的各个层面：谵妄的转化研究（生物标志物、基因组学、高级神经影像学）、解决方法论挑战的先进统计方法以及创新教育策略（例如交互式在线教育方法）。对于 Inouye 博士来说，K07 奖将为关键领导领域的进一步职业发展提供机会，并保护开发、全面实施、评估、完善和建立自我维持基础设施所需的时间，以确保该中心作为持久的中心继续存在。对老龄化研究和培训的贡献。 CEDARTREE 代表了此类资源中的第一个，提供了急需的创新型本地/国家资源和焦点，将提高老年谵妄研究的能力，最终目标是改善老年人的健康和生活质量。