Neurobehavioral and Functional Consequences of HIV in African Americans

非裔美国人艾滋病毒的神经行为和功能后果

基本信息

批准号：
8660340
负责人：
APRIL D THAMES
金额：
$ 18.92万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-05-01 至 2017-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8660340
关键词：
AIDS neuropathy AIDS/HIV problem Accounting Activities of Daily Living Affect African American Algorithms Anisotropy Anxiety Award Biological Brain Brain Mapping Caucasians Caucasoid Race Centers for Disease Control and Prevention (U.S.)Clinical Cognitive Communities Confounding Factors (Epidemiology)Consequences of HIV Data Diagnostic Disadvantaged Disease Education Educational workshop Ethnic Origin Ethnic group Functional disorder Funding Goals Gold Grant HIV HIV Infections HIV diagnosis Human Image Impaired cognition Impairment Individual Inequality Institutes International Knowledge Laboratories Lead Learning Life Link Measures Medication Management Mental Health Mentors Methods Metric Minority Modeling Molecular Neuroanatomy Neurocognitive Neurologic Dysfunctions Neuropsychological Tests Neuropsychology Neurovirology Patients Performance Pharmaceutical Preparations Population Psychology Public Health Reliance Research Research Proposals Science Social Conditions Societies Techniques Testing Training Training and Infrastructure Trauma Work Workplace base brain behavior career clinical decision-making cognitive neuroscience ethnic minority population experience functional outcomes gray matter health disparity improved literacy meetings neurobehavioral neurocognitive test neuroimaging neuropsychological programs socioeconomics statistics symposium white matter

项目摘要

DESCRIPTION (provided by applicant): This research proposal seeks to improve the understanding of HIV-associated neurocognitive impairment on "real-life" functional outcomes in African Americans (e.g., managing medications). The objective of this K23 application is to develop a model for predicting functional outcomes using methods of neuroimaging, neurocognitive assessment, and laboratory-based functional assessments, while controlling for potentially confounding sociocultural factors (e.g., educational experience). The following research proposal begins by first identifying sociocultural factors that explain differences in neurocognitive performance between African Americans and Caucasians. Next, we will use structural neuroimaging as an objective marker of brain organization to examine relationships between neurocognitive assessment and neuroimaging in both ethnic groups while modeling in potential explanatory variables. It is expected that the relationship between neurocognitive performance and neuroimaging will be strong for Caucasians, but relatively weak for African Americans (as this group is most often affected by disadvantaged social conditions). We expect that a model that factors in potential confounding variables will increase the validity of neurocognitive testing for measuring brain function and functional outcomes among African Americans. The candidate has a background in clinical neuropsychology and seeks two primary training goals from this award: 1) learn structural neuroimaging techniques, and 2) become an expert in NeuroAIDS, within emphasis on ethnic minority populations. The candidate's work environment at the UCLA Center for Cognitive Neuroscience and Semel Institute provides an excellent infrastructure for training in neuroimaging and NeuroAIDS. These labs have several funded, ongoing studies with strong ties to the Brain Mapping Center and the Laboratory of Molecular Neuroimaging (LONI). As part of this training, the candidate will attend courses and workshops in foundational neuroimaging topics (programming, statistics, image acquisition, neuroanatomy) and more advanced neuroimaging topics (e.g., DTI interpretation), as well as courses in the biological and neuropsychological sequelae of HIV infection. Training in cross-cultural psychology will be obtained through coursework offered through the Diversity Science Division within the Department of Psychology, weekly meetings with the Center for Culture, Trauma, and Mental Health and the Cultural Neuropsychology Initiative, in addition to weekly meetings with Dr. Hector Myers. She will also attend annual conferences in HIV (e.g., International Society of Neurovirology) and neuroimaging (e.g., Human Brain Mapping), and meet with mentors regularly. The candidate plans to apply for a R01 grant toward the end of the award period. Long term, she plans to establish an independent research career in health disparities focusing on brain-behavior relationships, cultural neuropsychology, and "real-world" functional outcomes.

描述（由申请人提供）：本研究提案旨在提高对非裔美国人“现实生活”功能结果（例如，管理药物）的 HIV 相关神经认知损伤的理解。该 K23 应用程序的目标是开发一个模型，使用神经影像学、神经认知评估和基于实验室的功能评估方法来预测功能结果，同时控制潜在的混淆社会文化因素（例如教育经历）。以下研究提案首先确定解释非裔美国人和白种人之间神经认知表现差异的社会文化因素。接下来，我们将使用结构神经影像作为大脑组织的客观标记，以检查两个种族的神经认知评估和神经影像之间的关系，同时对潜在的解释变量进行建模。预计白种人的神经认知表现和神经影像学之间的关系很强，但非裔美国人的关系相对较弱（因为该群体最常受到不利的社会条件的影响）。我们预计，考虑潜在混杂变量的模型将提高用于测量非裔美国人大脑功能和功能结果的神经认知测试的有效性。候选人具有临床神经心理学背景，并从该奖项中寻求两个主要培训目标：1）学习结构神经影像技术，2）成为神经艾滋病专家，重点关注少数族裔人群。候选人在加州大学洛杉矶分校认知神经科学中心和塞梅尔研究所的工作环境为神经影像和神经艾滋病培训提供了良好的基础设施。这些实验室有几项受资助的、正在进行的研究，与脑图谱中心和分子神经影像实验室 (LONI) 有着密切的联系。作为培训的一部分，候选人将参加基础神经影像主题（编程、统计、图像采集、神经解剖学）和更高级的神经影像主题（例如 DTI 解释）的课程和研讨会，以及生物和神经心理学后遗症的课程。艾滋病毒感染。跨文化心理学培训将通过心理学系多元化科学部门提供的课程、与文化、创伤和心理健康中心以及文化神经心理学倡议的每周会议以及与博士的每周会议来获得。赫克托·迈尔斯。她还将参加艾滋病毒（例如国际神经病毒学学会）和神经影像学（例如人脑图谱）的年度会议，并定期与导师会面。候选人计划在奖励期结束时申请 R01 补助金。从长远来看，她计划在健康差异方面建立独立的研究生涯，重点关注大脑行为关系、文化神经心理学和“现实世界”的功能结果。