The MIT Center for Single-Cell Dynamics in Cancer (SCDC)

麻省理工学院癌症单细胞动力学中心 (SCDC)

基本信息

批准号：
7942784
负责人：
ALEXANDER VAN OUDENAARDEN
金额：
$ 310.22万
依托单位：
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-28 至 2014-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7942784
关键词：
Academic Medical Centers Area Basic Cancer Research Behavior Biomedical Research Boston CCNE1 gene California Cancer Biology Cells Collaborations Commit Computer Simulation Computers Computing Methodologies Data Development Diagnosis Educational process of instructing Engineering Faculty Figs - dietary Focus Groups Gene Expression Gene Proteins Genome Goals Grant Head Hospitals Human Institutes Institution Knowledge Laboratories Location Malignant - descriptor Malignant Neoplasms Massachusetts Medical Monitor NCI Center for Cancer Research NCI-Designated Cancer Center Nanotechnology Netherlands Oncologist Physics Pre-Clinical Model Process Research Research Institute Research Personnel Research Project Grants Role San Francisco Schools Science Scientist Signal Transduction Systems Biology Technology Universities Ursidae Family Woman Work abstracting anticancer research base cancer therapy extracellular fight against innovation medical schools member multidisciplinary new technology news oncology physical science professor programs

项目摘要

The overall goal of this U54 application is to create and support a highly multidisciplinary team of expert oncologists, biologists, biochemists, engineers and both theoretical and experimental physicists. This team will form a Physical Science-Oncology Center (PS-OC) at the Massachusetts Institute of Technology for Single-Cell Dynamics in Cancer (SCDC). The overarching goal of this team is to use both theoretical and experimental approaches inspired by Physics and Engineering to attack important problems in cancer biology by developing novel technology and analytical/computational methods to track the dynamics of cancer at the single cell level. Most investigators from our team are affiliated with institutes in the Boston area including MIT, the Whitehead Institute for Biomedical Research, the Broad Institute of MIT and Harvard, Harvard Medical School, Brigham and Women's Hospital, and Boston University. Institutions from several other investigators are located at the West coast including the University of California, San Francisco and Stanford University. One of team members is located at the Hubrecht Institute and University Medical Center Utrecht in the Netherlands. The SCDC PS-OC will be based on close collaborations between investigators originating from three fields: cancer biology, experimental physics/engineering and theoretical/computational physics. In Project 1 single-cell transcript counting will be use to develop quantitative models of stem cell differentiation and reprogramming in healthy tissue and cancer. Project 2 utilizes complementary in silico, in vitro, and in vivo studies to deconvolute Ras signaling networks in T cell lymphoma. Project 3 will explore the coordination of cell growth and division in normal and cancer cells and Project 4 focuses on characterizing the load of driver and passenger mutations in cancer by modeling neoplastic progression and analyzing genomic data. All projects will make extensive of the Single-Cell Transcript Counting Core and the Cell Sorting and Physical Measurement Core. These facilities and all reagents generated by the cores will be made available to other PS-OCs.

U54 应用程序的总体目标是创建并支持一个由肿瘤学家、生物学家、生物化学家、工程师以及理论和实验物理学家组成的高度多学科团队。该团队将在麻省理工学院癌症单细胞动力学 (SCDC) 组建物理科学肿瘤中心 (PS-OC)。该团队的总体目标是利用受物理和工程学启发的理论和实验方法来解决癌症中的重要问题通过开发新技术和分析/计算方法来跟踪单细胞水平上的癌症动态。我们团队的大多数研究人员都隶属于波士顿地区的机构，包括麻省理工学院、怀特海德生物医学研究所、麻省理工学院和哈佛大学博德研究所、哈佛医学院、布莱根妇女医院和波士顿大学。其他几位研究人员的机构位于西海岸，包括加州大学旧金山分校和斯坦福大学。其中一名团队成员位于荷兰的 Hubrecht 研究所和乌得勒支大学医学中心。 SCDC PS-OC 将基于来自三个领域的研究人员之间的密切合作：癌症生物学、实验物理/工程和理论/计算物理。在项目 1 中，单细胞转录本计数将用于开发干细胞的定量模型健康组织和癌症的分化和重编程。项目 2 利用互补的计算机、体外和体内研究来解构 T 细胞淋巴瘤中的 Ras 信号网络。项目 3 将探索正常细胞和癌细胞中细胞生长和分裂的协调，项目 4 侧重于通过对肿瘤进展进行建模和分析来表征癌症中驱动突变和乘客突变的负载。基因组数据。所有项目都将广泛使用单细胞转录本计数核心以及细胞分选和物理测量核心。这些设施和核心产生的所有试剂将可供其他 PS-OC 使用。