ANALYSIS OF BODY FAT USING MRI/MRS IN HEALTHY CHILDREN AND IN CYSTIC FIBROSIS

使用 MRI/MRS 分析健康儿童和囊性纤维化患者的体脂

• 批准号: 8167202
• 负责人: Talissa A Altes
• 金额: $ 1.34万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-01 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167202
• 关键词: Adult; Age; Body fat; Body mass index; Child; Childhood; Computer Retrieval of Information on Scientific Projects Database; Cystic Fibrosis; Data; Detection; Disease; Evaluation; Fatty acid glycerol esters; Funding; Grant; Height; Institution; Knowledge; Leg; Liver; Measurement; Measures; Methods; Muscle; Normal Range; Overweight; Pediatric Hospitals; Philadelphia; Population; Research; Research Personnel; Resources; Skinfold Thickness; Source; United States National Institutes of Health; Weight; arm; children with cystic fibrosis; cystic fibrosis patients; lipid metabolism; metabolic abnormality assessment; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. MRI/MRS has been shown to be a fast, safe and non-invasive method for measuring fat content in the liver and has proven to be an important tool for muscle lipid metabolism studies. Most of the prior studies on MRI/MRS of body fat have included only adults and to our knowledge no prior study has included the non-overweight pediatric population. This study will assess the liver and muscle fat content in healthy non-overweight children. Obtaining a range of normal values in healthy non-overweight children will aid in detection and evaluation of liver and muscle fat content in other diseases, such as in children with Cystic Fibrosis (CF). A prior study was performed at Children's Hospital of Philadelphia (CHOP) using MRI/MRS to assess liver and muscle fat accumulation in children with CF. One of the difficulties in interpreting the data is that normative data from healthy children of a similar weight and age is not available. The purpose of this study is to collect the normative data from healthy control subjects for comparison with the results obtained in patients with CF. In this study, healthy children 10 years or older will have their height and weight, and size of their waist, arms and legs skin fold thicknesses measured. An MRI/MRS of the liver and lower leg muscle will be performed. Body mass index (BMI) will be calculated. Hypothesis: Body fat measurements in normal weight children will differ from existing data in overweight children. The data for normal children is required for comparison with data from children with diseases such as cystic fibrosis.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 MRI/MRS已被证明是一种快速、安全、无创的测量肝脏脂肪含量的方法，并被证明是肌肉脂质代谢研究的重要工具。 大多数关于身体脂肪的 MRI/MRS 的研究仅包括成年人，据我们所知，先前的研究尚未包括非超重的儿童群体。 这项研究将评估健康非超重儿童的肝脏和肌肉脂肪含量。 获得健康非超重儿童的一系列正常值将有助于检测和评估其他疾病（例如患有囊性纤维化（CF）的儿童）的肝脏和肌肉脂肪含量。 费城儿童医院 (CHOP) 之前进行了一项研究，使用 MRI/MRS 评估 CF 儿童的肝脏和肌肉脂肪积累情况。 解释数据的困难之一是无法获得体重和年龄相似的健康儿童的规范数据。 本研究的目的是收集健康对照受试者的规范数据，以便与 CF 患者获得的结果进行比较。 在这项研究中，将测量 10 岁或以上的健康儿童的身高和体重，以及腰围、手臂和腿部的尺寸以及皮肤褶皱的厚度。 将进行肝脏和小腿肌肉的 MRI/MRS。 将计算体重指数 (BMI)。 假设：正常体重儿童的体脂测量值将不同于超重儿童的现有数据。 需要正常儿童的数据与患有囊性纤维化等疾病的儿童的数据进行比较。