Central Mechanisms for Cardioprotective Behavioral Effects of W-3 Fatty Acids

W-3 脂肪酸心脏保护行为作用的核心机制

基本信息

批准号：
8021782
负责人：
Peter J Gianaros
金额：
$ 30.3万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-02-09 至 2013-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8021782
关键词：
Accounting Adult Affect Affective American Amygdaloid structure Anger Area Behavior Behavioral Brain Brain imaging Cardiac Cardiovascular Diseases Cardiovascular system Clinical Clinical Trials Collection Comorbidity Consumption Corpus striatum structure Data Data Collection Decision Making Diet Dietary intake Docosahexaenoic Acids Eicosapentaenoic Acid Emotions Essential Fatty Acids Event Fatty Acids Fish Oils Fishes Functional Magnetic Resonance Imaging Habits Health Health behavior Heart Diseases Hippocampus (Brain)Hostility Human Imaging Techniques Impaired health Impulsive Behavior Individual Inflammation Intake Intervention Life Style Light Magnetic Resonance Imaging Major Depressive Disorder Measures Mediating Mental disorders Morphology National Heart, Lung, and Blood Institute Neurobiology Nutrient Omega-3 Fatty Acids Participant Patients Primary Prevention Regulation Research Rewards Risk Factors Source Stimulus Suggestion Supplementation Support System System Testing Ventral Striatum behavioral health biobehavior brain morphology cardiovascular disorder prevention cardiovascular disorder risk depressive symptoms discounting gray matter intervention effect neuroimaging neuromechanism post intervention programs psychosocial randomized placebo controlled trial relating to nervous system response trait

项目摘要

DESCRIPTION (provided by applicant): Most Americans consume low quantities of long-chain omega-3 (-3) fatty acids, despite clinical evidence that increasing dietary intake of long-chain -3 fatty acids by fish consumption or fish oil supplementation reduces major cardiovascular disease (CVD) events. Moreover, despite clinical evidence of their efficacy, the mechanisms by which long-chain -3 fatty acids protect against CVD events remain uncertain. Because long- chain -3 fatty acids are concentrated in the brain and appear to have efficacy in the treatment of psychiatric disorders that are highly co-morbid with CVD, -3 fatty acid CVD protection may derive, in part, from salutary effects on brain-mediated behavioral risk factors for heart disease. In line with this suggestion, this 2-year ancillary research plan seeks to augment data collection of an ongoing randomized and placebo-controlled trial of -3 fatty acid supplementation, which is a component of our current NHLBI Program Project, "Biobehavioral Studies of Cardiovascular Disease" (HL040962). The aims of this ongoing trial are to test the effects of increasing intake of the key -3 fatty acids - eicosapentaenoic and docosahexaenoic acids (EPA, DHA) - on targets of CVD prevention, including systemic inflammation, cardiac autonomic control, and two brain-mediated behavioral CVD risk factors: negative affect (e.g., depressive symptomatology, hostility, and anger-related traits), and reward-related impulsive decision-making and delay discounting (predisposing to health-impairing habits of lifestyle). To augment our ongoing clinical trial in light of converging neurobiological evidence, we specifically propose to utilize contemporary structural and functional brain imaging techniques to examine the longitudinal effects of -3 fatty acids on brain systems implicated in affect regulation and impulsive decision- making. In this way, the proposed research would determine if increased EPA and DHA consumption reduces (from pre-to-post trial assessments) the reactivity of the amygdala to negative affect-related stimuli, and if increased EPA and DHA consumption the reduces reactivity of the ventral striatum to reward-related stimuli. Finally, the proposed research would explore possible longitudinal effects of increased intake of -3 fatty acids on gray matter morphology in prefrontal, amygdalar, hippocampal, or striatal areas implicated in affective and reward-related behaviors. PUBLIC HEALTH RELEVANCE: Omega-3 fatty acids are essential nutrients for both cardiovascular and behavioral health, and recent trials demonstrate that increasing dietary intake of omega-3 fatty acids protects against cardiovascular disease events. This proposal would augment our ongoing clinical trial in healthy adults by providing for longitudinal assessments of structural and functional brain imaging data, enabling us to determine the potential neural mechanisms for the putative effects of omega-3 fatty acids on two behavioral risk factors for cardiovascular disease - negative affect and impulsive decision-making (as related to health behavior choices).

描述（由申请人提供）：尽管临床证据表明，通过食用鱼类或补充鱼油来增加长链 -3 脂肪酸的饮食摄入量可减少主要心血管疾病 (CVD) 事件，但大多数美国人摄入的长链 omega-3 (-3) 脂肪酸含量较低。此外，尽管临床证据表明其功效，长链-3脂肪酸预防CVD事件的机制仍不确定。由于长链 -3 脂肪酸集中在大脑中，并且似乎对治疗与 CVD 高度共存的精神疾病有效，因此 -3 脂肪酸的 CVD 保护作用可能部分源自对大脑的有益作用- 介导的心脏病行为危险因素。根据这一建议，这项为期 2 年的辅助研究计划旨在扩大正在进行的补充 -3 脂肪酸的随机和安慰剂对照试验的数据收集，该试验是我们当前的 NHLBI 计划项目“心血管生物行为研究”的一部分疾病”（HL040962）。这项正在进行的试验的目的是测试增加关键的 -3 脂肪酸 - 二十碳五烯酸和二十二碳六烯酸（EPA、DHA）的摄入量对 CVD 预防目标的影响，包括全身炎症、心脏自主控制和两个大脑 -介导的行为性心血管疾病危险因素：负面影响（例如抑郁症状、敌意和愤怒相关特征），以及与奖励相关的冲动决策和延迟折扣（倾向于损害健康的生活方式）。为了根据神经生物学证据加强我们正在进行的临床试验，我们特别建议利用当代结构和功能脑成像技术来检查-3脂肪酸对涉及情感调节和冲动决策的大脑系统的纵向影响。通过这种方式，拟议的研究将确定增加 EPA 和 DHA 消耗是否会降低（从试验前到试验后评估）杏仁核对负面情绪相关刺激的反应性，以及增加 EPA 和 DHA 消耗是否会降低杏仁核的反应性。腹侧纹状体对奖励相关的刺激。最后，拟议的研究将探讨增加-3脂肪酸摄入量对与情感和奖励相关行为有关的前额叶、杏仁核、海马或纹状体区域灰质形态的可能的纵向影响。公共健康相关性：Omega-3 脂肪酸是心血管和行为健康的必需营养素，最近的试验表明，增加膳食中 omega-3 脂肪酸的摄入量可以预防心血管疾病事件。该提案将通过提供结构和功能脑成像数据的纵向评估来增强我们正在进行的健康成人临床试验，使我们能够确定 omega-3 脂肪酸对心血管疾病的两种行为危险因素的假定影响的潜在神经机制- 负面影响和冲动决策（与健康行为选择相关）。