Classical Associative Learning in Male and Female Alcoholics
男性和女性酗酒者的经典联想学习
基本信息
- 批准号:7797119
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-10-01 至 2013-09-30
- 项目状态:已结题
- 来源:
- 关键词:AffectAlcohol abuseAlcohol consumptionAlcohol-Related DisordersAlcoholismAlcoholsAmericasAnimal ModelAnimalsAnisotropyBehavioralBilateralBiological MarkersBlinkingBrainBrain regionCerebellar degenerationCerebellumChronicCognitionCognitiveComplexControl GroupsCritical PathwaysDataDeteriorationDiabetes MellitusDiffusionDiffusion Magnetic Resonance ImagingDiscriminationDiscrimination LearningDiseaseEnvironmentFemaleFundingHeadHealthHeavy DrinkingHumanHypertensionImage AnalysisImpaired cognitionImpairmentIndividualLaboratoriesLearningLiteratureMagnetic Resonance ImagingMapsMeasuresMedialMediatingMethodsMissionNeuropsychological TestsNeuropsychologyOutcomeParticipantPatient CarePatternPerformancePrevalenceProblem behaviorProceduresProductionRecording of previous eventsRelative (related person)ResearchResolutionReversal LearningRiskRoleShort-Term MemoryStatistical ModelsStructureSurfaceSystemTechniquesTemporal LobeTestingThalamic structureThickTimeTissuesVariantVeteransWorkabstractingalcohol misusealcohol riskbasebrain behaviorbrain volumecerebrovascularclassical conditioningcognitive functioncognitive systemconditioningexecutive functionfrontal lobegray matterindexinginterestmalemorphometryneuropsychologicalproblem drinkerrelating to nervous systemresponsestatisticswhite matter
项目摘要
DESCRIPTION (provided by applicant):
Abstract This proposal represents a continuation of a body of work that our laboratory has undertaken to examine the cognitive consequences of alcohol abuse in veterans. Alcohol misuse is a costly and functionally devastating problem that is pervasive among America's veterans, with nearly two and a half times the lifetime prevalence of alcohol-related disorders of nonveterans. Our laboratory has pioneered the use of the eyeblink classical, or Pavlovian, conditioning paradigm as a behavioral biomarker for neuropathological changes in the brain of male and female alcoholics. Our work from the prior funding period examined the acquisition of classically conditioned eyeblink responses to study the consequences of heavy drinking in abstinent chronic alcoholic individuals. This paradigm, based on Pavlovian conditioning as an index of a fundamental unit of learning, has well documented neural correlates in animal models, and has proven itself to be very sensitive to even subtle alterations in human neuropsychological disorders. Our data demonstrate that abstinent alcoholics are differentially impaired in the acquisition of these classically conditioned eyeblink responses. Now, using advanced high resolution imaging and analysis techniques, we have begun to identify alcohol-related degeneration of white matter microstructure using diffusion tensor imaging and have found associations between white matter integrity and performance on eyeblink classical conditioning. Preliminary data also reveal bilateral cortical thickness reductions in alcoholics compared to control participants in brain regions that are known to support eyeblink conditioning. The present study proposes to confirm and extend these preliminary observations in a comprehensive study examining the impact of heavy alcohol use on brain structure (using DTI maps of tissue microstructure and cortical thickness and regional brain volumes to characterize gray matter deterioration), and the associated impact of this deterioration on cognition using performance on eyeblink classical conditioning as a sensitive behavioral biomarker. Elevated cerebrovascular risk is a common comorbid condition of heavy alcohol use that impacts many of the same brain regions and cognitive functions that are impacted by abuse. It is likely that comorbid CVD risk contributes significantly to the degenerative neural environment and associated cognitive decline observed in alcoholics. Thus we will include a control group of normal drinkers with a matched distribution of CVD risk to the heavy alcohol drinkers to evaluate the independent and synergistic effects of CVD risk and alcohol. The successful completion of the aims proposed will add to our knowledge of the neuropsychology of alcoholism by clarifying the relative roles of the cerebellum, medial temporal lobe, frontal cortex and underlying white matter as they relate to the acquisition of new learning within the context of an extremely well understood learning task. We feel the hypothesized changes in brain structure and associated impairments in new learning underlie some of the intractable behavioral problems that characterize alcoholism.
PUBLIC HEALTH RELEVANCE:
Relevance to VA Patient Care Mission Alcohol abuse is a costly and functionally devastating problem that is pervasive among America's veterans. Prevalence rates of alcohol-related disorders among veterans are nearly two and a half times the lifetime prevalence of alcohol-related disorders of nonveterans. Because of the direct impact alcohol may have on cognitive function and treatment, there is a fundamental need for a more complete understanding of the cognitive sequelae of alcohol use and misuse in both male and female veterans. Using classical conditioning methods, our data demonstrate that abstinent alcoholics are differentially impaired in the acquisition of these classically conditioned eyeblink responses and suggest that the pattern of deficits observed may underlie some of the intractable behavioral problems that characterize alcoholism.
描述(由申请人提供):
摘要 该提案是我们实验室为研究退伍军人酗酒造成的认知后果而开展的一系列工作的延续。酒精滥用是一个代价高昂且功能性破坏的问题,在美国退伍军人中普遍存在,与酒精相关疾病的患病率几乎是非退伍军人一生中的两倍半。我们的实验室率先使用眨眼经典或巴甫洛夫条件反射范式作为男性和女性酗酒者大脑神经病理变化的行为生物标志物。我们在上一个资助期间的工作检查了经典条件性眨眼反应的获得,以研究戒酒的慢性酗酒者的大量饮酒的后果。这种范式基于巴甫洛夫条件反射作为学习基本单位的指标,在动物模型中已充分记录了神经相关性,并且已证明其对人类神经心理疾病的细微变化非常敏感。我们的数据表明,戒酒者在获得这些经典条件性眨眼反应方面受到不同程度的损害。现在,利用先进的高分辨率成像和分析技术,我们已经开始利用扩散张量成像来识别与酒精相关的白质微观结构变性,并发现白质完整性与眨眼经典条件反射表现之间的关联。初步数据还显示,与对照组参与者相比,酗酒者的双侧皮质厚度减少了已知支持眨眼调节的大脑区域。本研究建议在一项综合研究中确认和扩展这些初步观察结果,该研究检查重度饮酒对大脑结构的影响(使用组织微观结构和皮质厚度以及区域脑体积的 DTI 图来表征灰质退化)以及相关影响使用眨眼经典条件反射的表现作为敏感的行为生物标志物来描述这种认知恶化。脑血管风险升高是大量饮酒的常见并发症,它会影响许多受滥用影响的相同大脑区域和认知功能。共病 CVD 风险可能对酗酒者中观察到的神经环境退化和相关认知能力下降有显着影响。因此,我们将纳入正常饮酒者的对照组,并将 CVD 风险与重度饮酒者的 CVD 风险分布相匹配,以评估 CVD 风险和酒精的独立和协同效应。成功完成所提出的目标将通过澄清小脑、内侧颞叶、额叶皮层和底层白质的相对作用,增加我们对酗酒神经心理学的了解,因为它们与在酒精中毒的背景下获得新的学习有关。非常好理解的学习任务。我们认为,大脑结构的假设变化以及新学习中的相关损伤是酗酒特征的一些棘手行为问题的根源。
公共卫生相关性:
与退伍军人管理局患者护理任务的相关性 酗酒是一个代价高昂且具有破坏性的问题,在美国退伍军人中普遍存在。退伍军人中酒精相关疾病的患病率几乎是非退伍军人中酒精相关疾病终生患病率的两倍半。由于酒精可能对认知功能和治疗产生直接影响,因此迫切需要更全面地了解男性和女性退伍军人因饮酒和滥用酒精而造成的认知后遗症。使用经典条件反射方法,我们的数据表明,戒酒者在获得这些经典条件反射眨眼反应方面受到不同程度的损害,并表明观察到的缺陷模式可能是酗酒特征的一些棘手行为问题的基础。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
REGINA MCGLINCHEY其他文献
REGINA MCGLINCHEY的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('REGINA MCGLINCHEY', 18)}}的其他基金
Classical Associative Learning in Male and Female Alcoholics
男性和女性酗酒者的经典联想学习
- 批准号:
7916663 - 财政年份:2009
- 资助金额:
-- - 项目类别:
Classical Associative Learning in Male and Female Alcoholics
男性和女性酗酒者的经典联想学习
- 批准号:
8392945 - 财政年份:2009
- 资助金额:
-- - 项目类别:
Classical Associative Learning in Male and Female Alcoholics
男性和女性酗酒者的经典联想学习
- 批准号:
8195958 - 财政年份:2009
- 资助金额:
-- - 项目类别:
Cognitive Changes Associated with Chronic Alcohol Abuse
与慢性酒精滥用相关的认知变化
- 批准号:
6827070 - 财政年份:2004
- 资助金额:
-- - 项目类别:
Cognitive Changes Associated with Chronic Alcohol Abuse
与慢性酒精滥用相关的认知变化
- 批准号:
7283250 - 财政年份:2004
- 资助金额:
-- - 项目类别:
Cognitive Changes Associated with Chronic Alcohol Abuse
与慢性酒精滥用相关的认知变化
- 批准号:
7116448 - 财政年份:2004
- 资助金额:
-- - 项目类别:
Cognitive Changes Associated with Chronic Alcohol Abuse
与慢性酒精滥用相关的认知变化
- 批准号:
7493102 - 财政年份:2004
- 资助金额:
-- - 项目类别:
Cognitive Changes Associated with Chronic Alcohol Abuse
与慢性酒精滥用相关的认知变化
- 批准号:
6951999 - 财政年份:2004
- 资助金额:
-- - 项目类别:
相似国自然基金
年龄与异质对酗酒影响的建模与分析
- 批准号:11861044
- 批准年份:2018
- 资助金额:39.0 万元
- 项目类别:地区科学基金项目
酗酒相关问题的建模及研究
- 批准号:11461041
- 批准年份:2014
- 资助金额:36.0 万元
- 项目类别:地区科学基金项目
酗酒者易患肺部感染及高致死率的发病机制研究
- 批准号:U1404814
- 批准年份:2014
- 资助金额:30.0 万元
- 项目类别:联合基金项目
与酗酒毒害性相关的细胞色素CYP2E1蛋白酶催化反应机理及动力学的理论研究
- 批准号:21273095
- 批准年份:2012
- 资助金额:78.0 万元
- 项目类别:面上项目
酗酒促发外伤性蛛网膜下腔出血的生物力学机制及其量化法医病理学鉴定的研究
- 批准号:30772458
- 批准年份:2007
- 资助金额:28.0 万元
- 项目类别:面上项目
相似海外基金
Neuromelanin MRI: A tool for non-invasive investigation of dopaminergic abnormalities in adolescent substance use.
神经黑色素 MRI:一种用于非侵入性调查青少年物质使用中多巴胺能异常的工具。
- 批准号:
10735465 - 财政年份:2023
- 资助金额:
-- - 项目类别:
Improving outcomes for substance-affected families in the child welfare system
改善儿童福利系统中受药物影响的家庭的成果
- 批准号:
10734742 - 财政年份:2023
- 资助金额:
-- - 项目类别:
A genetically informative approach to understanding the impact of spousal psychiatric disorders on alcohol use disorder onset, remission, and relapse
一种了解配偶精神疾病对酒精使用障碍发作、缓解和复发影响的遗传信息方法
- 批准号:
10718384 - 财政年份:2023
- 资助金额:
-- - 项目类别:
Improving Methods for Dealing with Missing Data in Drug Use and Addiction Research: The Use of Later-Retrieval in Ecological Momentary Assessment
改进处理药物使用和成瘾研究中缺失数据的方法:后期检索在生态瞬时评估中的应用
- 批准号:
10721443 - 财政年份:2023
- 资助金额:
-- - 项目类别:
Identifying Factors Influencing Alcohol Use after Bariatric Surgery: An Ecological Momentary Assessment
确定减肥手术后影响饮酒的因素:生态瞬时评估
- 批准号:
10439039 - 财政年份:2023
- 资助金额:
-- - 项目类别: