Measurement and Analysis of Aging, Cognition and Alzheimer's Disease and Related Dementia (ADRD) Risk Factors at Midlife in the Kenya Life Panel Survey (KLPS)

肯尼亚生活追踪调查 (KLPS) 中年衰老、认知和阿尔茨海默病及相关痴呆 (ADRD) 危险因素的测量和分析

• 批准号: 10618926
• 负责人: EDWARD ANDREW MIGUEL
• 金额: $ 144.22万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-15 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10618926
• 关键词: Adult; Affect; Africa South of the Sahara; African; Aftercare; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Attitude; Back; Biological Assay; Biological Markers; Blood; Characteristics; Child; Child Health; Childhood; Cognition; Cognitive; Data; Data Collection; Data Set; Dementia; Diabetes Mellitus; Diagnosis; Disadvantaged; Discipline; Dryness; Education; Elderly; Freezing; Funding; Future; Genetic Markers; Hand Strength; Health; Health Status; Health behavior; Hypertension; Impaired cognition; Individual; Inflammation; Intervention; Interview; Kenya; Language; Life; Life Cycle Stages; Link; Literature; Living Standards; Marketing; Measurement; Measures; Memory; Mental Depression; Mental Health; National Institute of Child Health and Human Development; Nutritional; Obesity; Occupational; Occupations; Outcome; Participant; Pathway interactions; Patient Self-Report; Pharmaceutical Preparations; Phenotype; Physical activity; Predictive Factor; Prevalence; Primary Schools; Protocols documentation; Random Allocation; Randomized; Recording of previous events; Research Personnel; Respondent; Risk Factors; Sampling; Schools; Smoking; Social Interaction; Socioeconomic Status; Spottings; Stress; Surveys; Testing; Time; Uncertainty; Validation; Variant; Visuospatial; Work; achievement test; behavioral outcome; cognitive performance; cognitive testing; cohort; dementia risk; design; diabetes control; disability; drinking; economic outcome; emerging adult; executive function; field survey; health data; human old age (65+); instrumental activity of daily living; mental state; middle age; migration; novel; physical conditioning; programs; public health intervention; sleep pattern; social; social contact; sociodemographics; study population; young adult

Project Summary/Abstract Alzheimer’s disease is severely under-studied in Sub-Saharan Africa: the few existing estimates suggest that prevalence is currently low but changing risk factors predict that it could double in the next 20 years. We propose to study risk factors for Alzheimer’s disease and related dementias (AD/ADRD) in the Kenya Life Panel Survey (KLPS), a unique, richly phenotyped cohort of Kenyan adults who have been followed since childhood, and who were participants in a randomized child health intervention (school-based deworming). The existing dataset contains information on health, cognition, educational, demographic, social attitudes, and labor market outcomes for over 6,500 Kenyans first surveyed in 1998 (at ages 8-15) through 2021 (ages 31-39). KLPS thus provides an unusual opportunity to study cognition, and the determinants of AD/ADRD and related risk factors, over the life course, with direct measurement during childhood, young adulthood, and midlife. This project proposes an additional field interview in the KLPS Round 5 Aging Module (KLPS-5A) to collect detailed “midlife baseline” cognition and aging-related health data, as well as information on AD/ADRD risk factors, among participants, who will be 35 to 43 years old at the time of survey. One novel aspect is the ability to link these midlife measures to rich existing longitudinal data from childhood and early adulthood, including cognitive assessments (achievement and cognitive test scores), as well as educational outcomes, health status and behaviors, and economic outcomes (e.g., earnings, migration, occupational complexity) collected contemporaneously rather than via recall in later life. By combining state-of-the-art cognitive measures at this new midlife timepoint with the extensive cognitive measures and exposures already collected, we hope to establish KLPS as the premier African study of life-course dementia determinants. There are very few surveys globally that include such detailed data from childhood to old age, and these data would open up multiple avenues for investigating dementias tied to life-course disadvantages. We will make all data publicly available to researchers across disciplines. Another notable feature is the ability to utilize experimental variation from a randomized child health intervention that has been documented to meaningfully affect adult living standards and several risk factors for dementia, to better understand pathways over the life course and the scope for public health interventions to reduce AD/ADRD risk. The Primary School Deworming Program provided deworming medication to randomly-selected schools starting in 1998 in a region with high worm prevalence (>90%): 10 to 20 years after treatment, the intervention had positive effects on self-reported health, educational attainment; adult living standards; urban residential status, and occupation in the non-agricultural sector. This setting offers an unusual opportunity to experimentally test the extent to which an effective child health intervention can affect AD/ADRD risks and midlife health and cognition, as much of the associational literature suggests.

项目概要/摘要 撒哈拉以南非洲地区对阿尔茨海默病的研究严重不足：现有的少数估计表明， 目前患病率较低，但不断变化的风险因素预测未来 20 年患病率可能会翻一番。 提议在肯尼亚生活中研究阿尔茨海默病和相关痴呆症 (AD/ADRD) 的危险因素 小组调查（KLPS），一个独特的、表型丰富的肯尼亚成年人队列，自此以来一直受到跟踪 童年时期，以及谁是随机儿童健康干预（学校驱虫）的参与者。 现有数据集包含有关健康、认知、教育、人口、社会态度和劳动力的信息 1998 年（8-15 岁）至 2021 年（31-39 岁）首次对 6,500 多名肯尼亚人进行了市场结果调查。 因此，KLPS 为研究认知以及 AD/ADRD 和相关疾病的决定因素提供了一个不寻常的机会。 生命历程中的风险因素，在童年、青年期和中年期间进行直接测量。 该项目建议在 KLPS 第 5 轮老化模块 (KLPS-5A) 中进行额外的现场访谈，以收集 详细的“中年基线”认知和与衰老相关的健康数据，以及 AD/ADRD 风险信息 在调查时年龄为 35 岁至 43 岁的参与者中，一个新颖的方面是能力。 将这些中年衡量标准与童年和成年早期丰富的现有纵向数据联系起来，包括 认知评估（成绩和认知测试分数）以及教育成果、健康 收集的状况和行为以及经济成果（例如收入、移民、职业复杂性） 通过结合最先进的认知措施，同时而不是通过晚年的回忆。 新的中年时间点，通过已经收集的广泛认知测量和暴露，我们希望 将 KLPS 确立为非洲首屈一指的痴呆症终生决定因素研究 调查很少。 在全球范围内，包括从童年到老年的详细数据，这些数据将打开多个 调查与生命历程不利因素相关的痴呆症的途径 我们将公开所有数据。 给跨学科的研究人员。 另一个显着的特点是能够利用随机儿童健康状况的实验变异 已被记录的干预措施对成年人的生活水平和几个危险因素产生了重大影响 痴呆症，以更好地了解生命历程的途径以及公共卫生干预措施的范围 降低 AD/ADRD 风险 小学驱虫计划为学生提供驱虫药物。 从 1998 年开始在蠕虫流行率高 (>90%) 的地区随机选择学校：10 至 20 年后 治疗、干预对自我报告的健康、成年生活有积极影响； 标准；城市居住状况以及非农业部门的职业。 有机会通过实验测试有效的儿童健康干预措施对 AD/ADRD 的影响程度 正如许多相关文献所表明的那样，风险、中年健康和认知。