UAB National Coordinating Center for the George M. O'Brien Kidney National Resource Centers

阿拉巴马大学乔治·M·奥布莱恩肾脏国家资源中心国家协调中心

• 批准号: 10747181
• 负责人: Amanda Hyre Anderson
• 金额: $ 119.33万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10747181
• 关键词: Accountability; Acute Renal Failure with Renal Papillary Necrosis; Address; Alabama; Applications Grants; Area; Biometry; Caring; Chronic Kidney Failure; Clinical and Translational Science Awards; Collaborations; Common Data Element; Communication; Communities; Consultations; Data; Data Analyses; Development; Educational workshop; Ensure; Entrepreneurship; Epidemiologist; Faculty; Feedback; Focus Groups; Funding; Goals; Grant; Health; High Prevalence; Hour; Incidence; Individual; Infrastructure; Institution; Investments; Kidney; Kidney Diseases; Lead; Mentors; Mentorship; National Institute of Diabetes and Digestive and Kidney Diseases; Outcome; Output; Pathway interactions; Patient-Focused Outcomes; Patients; Peer Review; Pilot Projects; Play; Procedures; Productivity; Protocols documentation; Published Comment; Research; Research Personnel; Research Priority; Resource Sharing; Resources; Role; Science; Scientist; Services; Societies; Students; Technology; Training; Training Programs; Translational Research; United States National Institutes of Health; Universities; Vision; Writing; data management; data portal; data sharing; data standards; drug development; education planning; equity, diversity, and inclusion; experience; improved; improved outcome; innovation; meetings; operation; outreach; patient engagement; patient oriented; peer; peer coaching; preference; prevent; programs; success; synergism; tool; virtual

For over 30 years, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) has funded the O’Brien Kidney Center program to advance kidney-related research. To expand the breadth and impact of these centers, NIDDK has modified this program by establishing the O’Brien Kidney Consortium. This consortium will include ~8 theme-based National Resource Centers (NRCs) tasked with developing and sharing specialized resources, tools, technologies, services, and expertise and a National Coordinating Center (NCC) to lead, manage, and harmonize all aspects of the Consortium. We propose the University of Alabama at Birmingham (UAB) to serve as the NCC for the O’Brien Kidney Consortium. Led by an epidemiologist (Dr. Paul Muntner) and nephrologist (Dr. Orlando Gutiérrez) and supported by nephrologists, biostatisticians, kidney physiologists, health behaviorists, and strong research mentors, the proposed NCC investigator team is interdisciplinary with experience participating in NIDDK-sponsored consortia. UAB has the infrastructure to lead the NCC including (1) An established Data Management and Analysis Center (DMAC) with an established data portal that has supported NIH-funded multi-center networks and implemented programs to enhance collaboration, common data elements, and data sharing, and (2) Experience engaging patients to ensure research addresses issues that are important to them, (3) A commitment to diversity/equity/ inclusion, (4) Drug development/ entrepreneurship expertise to facilitate the translation of research into better patient outcomes, and (4) Training programs that will provide support for early-stage investigators that spurs innovation and impact of their research. Additionally, the UAB investigators have implemented and administered competitive pilot grant programs that has nurtured the development and provided supported high- impact research ideas with a substantial return on investment. The UAB NCC has five aims including (1) Providing administrative support, facilitating communication and coordination, and enhancing synergy by implementing standard operating procedures and sub-committees for the O’Brien consortium; (2) Expanding the UAB DMAC to provide a portal for sharing protocols, data, tools and other resources for the O’Brien consortium; (3) Implementing a training plan that includes team science workshops, hierarchical, peer and near-peer mentoring, and virtual office hours for early-stages investigators to collaborate with the O’Brien NRCs; (4) Engaging patient viewpoints, priorities and preferences through focus groups and active scientist- patient interaction to inform the O’Brien NRCs and consortium; and (5) Administering a national pilot program with pre-submission scientific and biostatistics consultation, rigorous peer review, and ongoing mentorship to support early-stage investigators, investigators new to kidney research and collaborations with the broader kidney community. The UAB NCC will support NIDDK and the O’Brien Kidney Consortium to advance kidney research nationwide maximizing the impact on improving kidney health.

30 多年来，国家糖尿病、消化和肾脏疾病研究所 (NIDDK) 一直资助 奥布莱恩肾脏中心计划旨在推进肾脏相关研究，扩大研究的广度和影响。 针对这些中心，NIDDK 通过建立 O’Brien 肾脏联盟修改了该计划。 该联盟将包括约 8 个基于主题的国家资源中心 (NRC)，其任务是开发和 共享专业资源、工具、技术、服务和专业知识以及国家协调中心 (NCC) 领导、管理和协调联盟的各个方面。 阿拉巴马州伯明翰 (UAB) 担任由 O’Brien 肾脏联盟领导的 NCC。 流行病学家（Paul Muntner 博士）和肾脏病学家（Orlando Gutiérrez 博士）并得到肾脏病学家的支持， 生物统计学家、肾脏生理学家、健康行为学家和强大的研究导师，提议的 NCC 研究人员团队是跨学科的，具有参与 NIDDK 赞助的 UAB 联盟的经验。 领导 NCC 的基础设施包括 (1) 已建立的数据管理和分析中心 (DMAC) 拥有一个已建立的数据门户，支持 NIH 资助的多中心网络并实施 旨在加强协作、通用数据元素和数据共享的计划，以及 (2) 参与体验 患者确保研究解决对他们来说重要的问题，(3) 对多样性/公平/的承诺 包容性，(4) 药物开发/创业专业知识，以促进研究转化为更好的成果 患者的治疗结果，以及 (4) 为早期研究人员提供支持的培训计划，以激励 此外，UAB 研究人员还实施并实施了其研究的创新和影响。 管理竞争性试点拨款计划，培育发展并提供支持的高 UAB NCC 有五个目标，包括 (1) 提供行政支持，促进沟通协调，增强合力 (2) 扩展 UAB DMAC 为 O’Brien 提供共享协议、数据、工具和其他资源的门户 (3) 实施包括团队科学研讨会、分层、同行和 为早期研究人员提供与奥布莱恩合作的近同行指导和虚拟办公时间 NRC；(4) 通过焦点小组和活跃的科学家参与患者的观点、优先事项和偏好 患者互动，向 O’Brien NRC 和联盟通报情况；以及 (5) 管理国家试点计划； 通过提交前的科学和生物统计咨询、严格的同行评审以及持续的指导 支持早期研究人员、肾脏研究新手以及与更广泛领域的合作 UAB NCC 将支持 NIDDK 和 O’Brien 肾脏联盟推动肾脏发展。 全国范围内的研究最大限度地提高了改善肾脏健康的影响。