Core D: Neuroscience Core

核心 D：神经科学核心

• 批准号: 9292350
• 负责人: Karoly Mirnics
• 金额: $ 26.72万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9292350
• 关键词: Adopted; Amino Acids; Behavior; Behavioral; Biogenic Amines; Biological Assay; Collaborations; Communities; Core Facility; Custom; Dependence; Development; Discipline; Electronics; Ensure; Environment; Equipment; Equipment Design; Extramural Activities; Faculty Recruitment; Feedback; Funding; Genes; Genomics; Goals; High Pressure Liquid Chromatography; Human Resources; Incentives; Individual; Intellectual functioning disability; Interdisciplinary Study; Investments; Knowledge; Location; Maintenance; Measurement; Mental Retardation and Developmental Disabilities Research Centers; Methods; Mission; Molecular; Molecular Neurobiology; Mus; Neurosciences; Neurosciences Research; Perfusion; Phenotype; Prevention; Productivity; Protocols documentation; Research; Research Personnel; Research Project Grants; Sampling; Scientist; Services; Techniques; Technology; Testing; Training; Transcript; Universities; University resources; Work; base; behavior test; cost effective; cost efficient; design; design and construction; experience; gene function; gene product; instrumentation; interdisciplinary collaboration; interest; investigator training; medical specialties; meetings; neurochemistry; new technology; novel; programs; ranpirnase; repaired; satisfaction; senior faculty; success

NEUROSCIENCE CORE D ABSTRACT Project Summary The Neuroscience Core D services will: (1) provide IDDRC investigators with facilities and services to support their individual neuroscience research programs; (2) maintain an environment that facilitates interdisciplinary neuroscience collaborations among IDDRC investigators; (3) deliver broad access to emerging neuroscience technologies that would otherwise be inaccessible to individual IDDRC investigators; (4) ensure that the services provided are timely, of the highest quality, and cost-effective; (5) help IDDRC investigators better utilize existing Vanderbilt University research core facilities; and (6) provide incentives for the IDDRC recruitment of new junior and senior faculty. Four integrated core services and facilities are proposed to be supported by Neuroscience Core D: (1) Mouse Behavioral Phenotyping; (2) Neurochemistry; (3) Molecular Neurobiology and Genomics; and (4) Scientific Instrumentation, chosen by the combined criteria of relevance, impact, broadness, inclusiveness, value, investment, integration, and generativity. The Mouse Behavioral Phenotyping Core Service will provide IDDRC investigators with access to state-of-the-art equipment and space for assessing mouse behavior and also will provide comprehensive training in modern behavioral phenotyping methods. The Neurochemistry Core Service will provide quantitative assessment of biogenic amines and amino acids and user-initiated, newly developed, custom-designed measurements. The Molecular Neurobiology and Genomics Core Service develops and applies molecular protocols to investigate the expression and function of genes. The Scientific Instrumentation Service is responsible for maintenance/repair of existing equipment and design/construction of specialized scientific research equipment based on user demand. All these services have a simple, central goal: to facilitate cost-efficient discovery related to IDD research. Core D has substantial connections with our other proposed cores in the U54, and it will facilitate collaborative research and interdisciplinary interaction. Furthermore, in addition to serving 25 funded or pending IDD research-related projects, our Neurochemistry and Scientific Instrumentation core services will be heavily used by the proposed Research Project (PI: Wallace).

神经科学核心D摘要 项目摘要 神经科学核心D服务将：（1）为IDDRC调查人员提供支持的设施和服务 他们的个人神经科学研究计划； （2）维护促进跨学科的环境 IDDRC调查人员之间的神经科学合作； （3）提供对新兴神经科学的广泛访问 否则IDDRC调查人员将无法访问的技术； （4）确保 提供的服务是及时的，具有最高质量和成本效益； （5）更好地帮助IDDRC调查人员 利用现有的范德比尔特大学研究核心设施； （6）为IDDRC提供激励措施 招募新青少年和高级教师。 提议四个集成的核心服务和设施由Neuroscience核心D：（1）鼠标 行为表型； （2）神经化学； （3）分子神经生物学和基因组学； （4）科学 仪器，由相关性，影响，广泛，包容性，价值的联合标准选择 投资，整合和生成性。鼠标行为表型核心服务将提供IDDRC 可以使用最先进的设备和评估鼠标行为的空间的调查人员 提供现代行为表型方法的全面培训。神经化学核心服务 将提供对生物胺和氨基酸的定量评估以及新开发的用户启发， 定制设计的测量。分子神经生物学和基因组学核心服务正在发展，并且 应用分子方案来研究基因的表达和功能。科学仪器 服务负责维护/维修现有设备以及专业的设计/建设 基于用户需求的科学研究设备。 所有这些服务都有一个简单的中心目标：促进与IDD研究相关的成本效益发现。核 D与我们在U54中提出的其他核心有很大的联系，这将有助于协作 研究和跨学科互动。此外，除了为25个资助或待处理的IDD提供服务外 与研究相关的项目，我们的神经化学和科学仪器核心服务将大量使用 由拟议的研究项目（PI：Wallace）。