HIV Infection, Metabolites and Subclinical Atherosclerosis

HIV 感染、代谢物和亚临床动脉粥样硬化

• 批准号: 9120269
• 负责人: Qibin Qi
• 金额: $ 15.48万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE, INC
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-15 至 2019-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9120269
• 关键词: Acquired Immunodeficiency Syndrome; Advisory Committees; Affect; Amino Acids; Archives; Area; Aromatic Amino Acids; Atherosclerosis; Biochemical; Biological Markers; Biology of HIV Infection; Biometry; Blood Pressure; Blood specimen; Branched-Chain Amino Acids; CD4 Positive T Lymphocytes; Cardiovascular Diseases; Carotid Arteries; Carotid Artery Plaques; Carotid Atherosclerotic Disease; Cell Count; Chronic; Coagulation Process; Cohort Studies; Collaborations; Data; Diabetes Mellitus; Disease; Epidemiology; Fatty acid glycerol esters; Functional disorder; Future; General Population; Genes; Genetic; Glutamine; HIV; HIV Infections; Hepatitis C virus; Highly Active Antiretroviral Therapy; Human; Immune; Individual; Inflammation; Inflammatory; Insulin Resistance; Intervention; K-Series Research Career Programs; Learning; Life Expectancy; Lipids; Measurement; Measures; Mentored Research Scientist Development Award; Mentors; Mentorship; Metabolic; Molecular Weight; Morbidity - disease rate; Multicenter Studies; Pathogenesis; Pathway Analysis; Pathway interactions; Patients; Pharmaceutical Preparations; Plasma; Population; Prevention; Qi; RNA; Recording of previous events; Research; Research Personnel; Research Project Grants; Resources; Risk; Risk Factors; Source; Techniques; Training; Training Programs; Ultrasonography; Viral; Woman; Work; aged; antiretroviral therapy; blood lipid; cardiovascular disorder risk; career; cohort; design; diabetes risk; experience; follow-up; genomic data; gut microbiota; immune activation; insight; interest; intimal medial thickening; men; metabolomics; mortality; multidisciplinary; novel; potential biomarker; prospective; public health relevance; statistics; treatment duration; urea cycle

 DESCRIPTION (provided by applicant): This K01 Career Development Award application proposes a multidisciplinary 4-year training program to provide the candidate, Dr. Qibin Qi, with the experience and resources necessary to launch a successful career as an independent investigator. The training plan, developed closely with primary mentor Dr. Kaplan Robert, co-mentor Dr. Kathryn Anastos, and an Advisory Committee, will broaden Dr. Qi's research experience and expertise, including metabolomics, biostatistics and HIV infection and cardiovascular disease (CVD) epidemiology. The proposed research project, building upon two well-characterized HIV cohorts (the Women's Interagency HIV Study [WIHS] and the Multicenter AIDS Cohort Study [MACS]), offers the candidate an outstanding opportunity to become proficient in the novel area of metabolomics research as well as in HIV infection and CVD epidemiology. Taking advantage of archived blood samples, extensive data on HIV-infection related factors, longitudinal measurements of carotid artery plaque, and genomic data in the WIHS and MACS, this project proposes to examine plasma levels of metabolites among 495 women and men, aged = 45 years old, without carotid artery plaque at baseline (338 HIV+ and 157 HIV- subjects; 103 subjects had incident carotid plaque over 7-year follow-up measured by B mode ultrasound). Associations of HIV infection and related factors with prior informed cardiometabolic-associated metabolites (e.g., branched-chain amino acids), and associations between these metabolites and progression of subclinical carotid atherosclerosis (incident carotid artery plaque) will be examined. In exploratory analyses, advance analytical approached (e.g., network analysis) will be applied to identify novel metabolomic signatures related to HIV infection and subclinical atherosclerosis progression, and to generate a network illustrating interrelationships between genes, metabolites, HIV infection and CVD. In addition, potential HIV-specific metabolomic findings will be examined through collaborations with HIV-uninfected population studies. Findings from this study will provide preliminary data for a larger study proposal to measure metabolomics profiling more comprehensively and longitudinally. These studies will advance our understanding of pathogenesis of HIV infection and CVD and provide useful information for effective strategies in the prevention and management of CVD in HIV-infected patients.

 描述（由应用程序提供）：这项K01职业发展奖申请提案提案一项多学科的4年培训计划，旨在为候选人Qibin Qi博士提供成功，以成功地成为独立研究员的职业生涯所必需的经验和资源。该培训计划与主要导师Kaplan Robert博士紧密制定，同事Kathryn Anastos博士和咨询委员会将扩大Qi博士的研究经验和专业知识，包括代谢组学，生物统计学，HIV和HIV感染以及心血管疾病（CVD）的病理学。拟议的研究项目基于两个特征良好的HIV队列（妇女的妇女艾滋病毒艾滋病毒研究[WIHS]和多中心艾滋病队列研究[MACS]），为候选人提供了一个出色的机会，可以熟练地精通代谢组学研究的新领域以及HIV感染和HIV感染和CVD流行病学。利用归档的血液样本，有关HIV感染相关因素的大量数据，颈动脉牙菌斑的纵向测量以及WIHS和MAC中的基因组数据，该项目提出了在495名妇女和男性中的代谢水平，以检查45岁的女性，年龄= 45岁，没有Carotid Artery Artery Artery Artery plater Smare（33 HIV）（338 HIV），以及33 HIV+++通过B模式超声测量的7年随访的颈动脉斑块）。 HIV感染和相关因素与先前的知情心脏代谢相关代谢产物（例如，分支链氨基酸）以及这些代谢产物之间的关联与亚临床颈动脉粥样硬化（入射颈动脉斑块）之间的关联。在探索性分析中，将应用提前的分析方法（例如，网络分析）来识别与HIV感染和亚临床动脉粥样硬化进展相关的新型代谢组学特征，并产生一个网络，说明基因，代谢物，HIV感染和CVD之间的相互关系。此外，将通过与HIV未感染的人群研究的合作来检查潜在的HIV特异性代谢组发现结果。这项研究的发现将为大型研究建议提供初步数据，以更全面，纵向测量代谢组学分析。这些研究将促进我们对HIV感染和CVD发病机理的理解，并为在HIV感染的患者的预防和管理CVD方面提供有效的策略提供有用的信息。