Cleveland Clinic Pelvic Floor Disorders Network Clinical Site

克利夫兰诊所盆底疾病网络临床网站

• 批准号: 9178015
• 负责人: Marie Fidela Paraiso
• 金额: $ 1.9万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-12 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9178015
• 关键词: Affect; Age; Area; Basic Science; Biomedical Engineering; Caring; Clinic; Clinical; Clinical Research; Clinical Sciences; Clinical Trials; Collaborations; Colorectal Surgery; Conduct Clinical Trials; Data Coordinating Center; Development; Diagnosis; Diagnostic; Diagnostic tests; Discipline; Economics; Enrollment; Environment; Epidemiology; Evaluation; Evidence based treatment; Family; Fecal Incontinence; Female; Functional disorder; Future; Gastrointestinal tract structure; Goals; Graduate Education; Growth; Health; Health Sciences; Healthcare; Human Resources; Individual; Knowledge; Leadership; Lower urinary tract; Medicine; National Institute of Child Health and Human Development; Operative Surgical Procedures; Outcome Measure; Patients; Pelvic Floor Disorders; Pelvis; Physical therapy; Population Growth; Prevalence; Prevention strategy; Principal Investigator; Productivity; Publications; Radiology Specialty; Randomized Clinical Trials; Reconstructive Surgical Procedures; Recording of previous events; Reporting; Research; Research Design; Research Infrastructure; Research Methodology; Research Personnel; Resources; Role; Sensory; Services; Site; Symptoms; Therapeutic Intervention; Translational Research; Urinary Incontinence; Urology; Validation; Woman; clinical care; clinical research site; clinical risk; cost; design; economic cost; experience; follow-up; member; older women; pelvic organ prolapse; population based; postgraduate education; predictive modeling; psychosocial; response

The broad long-term objective of the NICHD Pelvic Floor Disorders Network (PFDN) is to perform multicenter research to study clinical and health aspects of pelvic floor disorders (PFD) with an emphasis on performing randomized clinical trials in order to reduce the burden of these conditions on women and their families. The Cleveland Clinic is seeking to successfully compete in the fourth cycle of the PFDN. The Cleveland Clinic PFDN Clinical Site joined the Network as one of its seven Clinical Sites at the beginning of the Network's 2nd 5- year cycle (2006) and has continued as a highly productive clinical site through its 2nd and 3rd cycles (2006- 2015). The specific aims of this application are to: 1) demonstrate that the Cleveland Clinic PFDN Site has contributed substantially to the academic, administrative, and clinical aspects of the PFDN during its 2nd and 3rd 5-year cycles; 2) demonstrate that we possess the personnel, patient, clinical and administrative resources needed for successful participation; and that our continued participation would be advantageous to the successful attainment of the Network's scientific goals, and 3) describe the unique strengths of the Cleveland Clinic Site relevant to PFD research. The Cleveland Clinic offers a stable, research-oriented environment for the conduct of Network studies includes highly experienced investigators with complementary clinical and research backgrounds with expertise in urogynecology, urology, colorectal surgery, physical therapy, epidemiology, radiology and biomedical engineering. Additionally, our site offers unique expertise in PFD outcome measure development and validation, development of clinical risk prediction models, and basic and translational research of PFDs. The Cleveland Clinic Center for Female Pelvic Medicine and Reconstructive Surgery provides care to a large volume of women with the full spectrum of PFD including urinary incontinence, fecal incontinence and pelvic organ prolapse and other sensory and emptying abnormalities of the lower urinary and gastrointestinal tracts with approximately 3,200 new patients seen and 3,900 surgeries performed annually. Our research team has a long and successful history of conducting clinical and translational research including clinical trials evaluating both surgical and non-surgical therapies for women with PFD. We have developed an infrastructure and environment conducive to the conduct of clinical studies of the PFDN and have made substantial contributions towards PFDN productivity including taking leadership in the design, implementation and publications of many PFDN studies and analyses. The unique strengths of the Cleveland Clinic Site have expanded and strengthened PFDN activities in the 2nd and 3rd cycle and will continue to be advantageous to the Network in the future. The health-relatedness of the PFDN and our application is that on-going and future Network studies will significantly advance the field by filling important gaps in our knowledge to expand evidence-based treatments for women with PFD.

NICHD骨盆底疾病网络（PFDN）的长期长期目标是执行多中心 研究骨盆底疾病（PFD）的临床和健康方面的研究，重点是执行 为了减轻妇女及其家人的这些条件的负担，随机临床试验。这 克利夫兰诊所正在寻求在PFDN的第四个周期中成功竞争。克利夫兰诊所 PFDN临床部位加入了网络，作为其七个临床部位之一。 年周期（2006年），并通过其第二个和第三个周期持续了高生产力的临床部位（2006-- 2015）。该应用程序的具体目的是：1）证明克利夫兰诊所PFDN网站具有 为PFDN的第二和第三章中的学术，行政和临床方面做出了重大贡献 5年周期； 2）证明我们拥有人员，患者，临床和行政资源 成功参与需要；我们继续参与将是对 成功实现了网络的科学目标，3）描述克利夫兰的独特优势 与PFD研究有关的诊所。克利夫兰诊所提供了一个稳定的，面向研究的环境 网络研究的进行包括经验丰富的互补临床研究人员 具有泌尿疗法，泌尿外科，结直肠手术，物理治疗方面的专业知识的研究背景， 流行病学，放射学和生物医学工程。此外，我们的网站在PFD中提供了独特的专业知识 结果测量的发展和验证，临床风险预测模型的发展以及基本和 PFD的翻译研究。克利夫兰女性骨盆医学和重建性诊所中心 手术为大量PFD的妇女提供护理 尿失禁，粪便尿失禁和骨盆器官脱垂以及其他感觉和排空异常 较低的尿和胃肠道，大约有3200例新患者和3,900例手术 每年执行。我们的研究团队在进行临床和 翻译研究包括评估女性手术和非手术疗法的临床试验 与PFD。我们已经开发了一种基础设施和环境，有利于进行临床研究 PFDN并为PFDN的生产力做出了重大贡献，包括领导 许多PFDN研究和分析的设计，实施和出版物。独特的优势 克利夫兰诊所现场在第二和第三周期扩大并加强了PFDN活动，将 将来继续对网络有利。 PFDN和我们的健康相关性 应用程序是持续的和未来的网络研究将通过填写重要 我们知识的差距扩大了PFD女性的基于证据的治疗。