M-Health Tools to Enhance Treatment of Teen Substance Abuse and Mental Illness

移动健康工具可加强青少年药物滥用和精神疾病的治疗

• 批准号: 9322641
• 负责人: Zachary William Adams
• 金额: $ 13.41万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2020-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9322641
• 关键词: Health; Tools; Enhance; Treatment; Teen

 DESCRIPTION (provided by applicant): The goal of this Mentored Patient-Oriented Research Career Development Award (K23) is to develop the candidate, Dr. Zachary Adams, into an independent investigator prepared to lead large-scale, rigorously designed studies evaluating the utility of mobile health (mHealth) technologies in improving treatment efficiency, efficacy, and reach among high-risk youth with substance use disorders (SUD) and comorbid mental illness. Comorbidity is common in adolescence and often complicates treatment progress. Use of mHealth approaches-such as mobile applications that tailor content to patients' specific needs, enhance patient engagement, and facilitate existing evidence-based treatments-holds great promise in reducing the public health burden of addiction and mental illness. This application proposes training and Stage IA-IB intervention development research that is directly in line with NIDA-supported initiatives and represents a logical progression from the candidate's prior research and training to address career development goals in six areas: (1) development of mobile applications for adolescent mental health, (2) etiology and treatment of comorbid SUD and trauma-related mental illness in adolescents, (3) conduct and evaluation of clinical trials, (4 multilevel and longitudinal data analysis, (5) grant management, and (6) research ethics. Goals will be accomplished through high caliber didactic training, participation in national conferences and institutes, and hands-on research experience. Activities will be completed under the mentorship of an accomplished team of expert on-site investigators in the fields of adolescent comorbidity and integrated treatments (Danielson), mHealth methodologies and evaluation (Treiber), technology-based mental health interventions (Ruggiero), [qualitative and mixed methods research (Pope)], and analysis of longitudinal, clinical trials data (Ramakrishnan). The candidate will apply these skills through completion of a three-component research project: (I) initial design and programming of a novel web-based mobile application to enhance outpatient treatment for comorbid SUD and posttraumatic stress disorder, (II) mixed method usability testing of the application by adolescents and providers to guide design and content refinements, and (III) a pilot trial to demonstrate the feasibility of the proposed methodology and to evaluate the preliminary efficacy of the application to guide design of an randomized controlled efficacy trial. An iterative, patient- and provider- centered development process will be employed to ensure relevance to the target population. The central hypothesis is that developmentally tailored mobile applications that incorporate evidence-based treatment principles can facilitate increased patient engagement in and between sessions, thus improving the efficiency, efficacy, and reach of treatments for this highly vulnerable population. After completing these projects, there will be a better understanding of how mHealth approaches can be used to augment existing treatments for comorbid SUD and mental illness. The experience, and data gained from this project will position the candidate to pursue future NIH funding to build this line of researc and to adapt and test future mHealth tools for adolescent substance abuse and mental health problems.

 描述（由适用提供）：这项受过指导的以患者为导向的研究职业发展奖（K23）的目的是将候选人扎卡里·亚当斯（Zachary Adams）博士发展成为一名独立的研究者，准备领导大规模，严格设计的研究，以评估移动健康（MHealth）技术（MHealth）技术在改善治疗效率效率，有效性，有效性的年轻人和调查者中的效用（MHealth）技术的实用性。合并症在青少年时期很常见，并且经常使治疗进展复杂化。使用MHealth的方法如移动应用程序，例如为患者的特定需求量身定制内容，增强患者的参与度，并支持现有的基于证据的治疗方法，以减少成瘾和精神疾病的公共卫生烧伤。该申请建议培训和IA-IB阶段干预开发研究直接符合NIDA支持的倡议，并代表候选人的先前研究和培训，以解决六个领域的职业发展目标：（1）在青少年精神健康中发展移动应用程序，（2）（2）（2）Comorbid Sudn和Traumain Cristialctial Contruma Cristical in Adection in Adectics（3（3）（3）（3）（3）多层次和纵向数据分析，（5）赠款管理和（6）研究道德将在成熟的专家现场调查员团队的心态下完成。纵向，临床试验数据（Ramakrishnan）。提出的方法的可行性并评估应用程序的初步效率，以指导随机对照效率试验的设计。将采用迭代，以患者和提供者为中心的发展过程来确保与目标人群相关。中心假设是开发了量身定制的移动应用，结合了循证治疗原则，可以促进会议之间和在会议之间的患者参与度的增加，从而提高这种高度脆弱的人群的效率，效率和治疗范围。完成这些项目后，将对如何使用MHealth方法来更好地了解合并症和精神疾病的现有治疗方法。从该项目获得的经验以及从该项目中获得的数据将使候选人购买未来的NIH资金，以建立这一恢复线，并适应和测试未来的MHealth工具，以解决青少年药物滥用和心理健康问题。