Admninstrative and Biostatistics Core

行政和生物统计学核心

基本信息

批准号：
9112849
负责人：
Troy D Randall
金额：
$ 9.83万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/9112849
关键词：
Acute Address Administrator Affect Agreement Autoimmunity B-Lymphocytes Biological Biometry Biostatistics Core Budgets Cell physiology Cells Chronic Clinical Sciences Collection Complex Computer software Consultations Contracts Control Groups Data Data Analyses Data Set Disease Ensure Epidemiologic Studies Expenditure Experimental Designs Funding Future Goals Grant Group Meetings Guidelines Health Host Defense Human Human Resources Immune Immune response Immunity Immunology Individual Institution Intervention Knowledge Lead Lymphoid Mediating Medicine Methods Microbiology Molecular Monitor Mus Organ Outcome Participant Policies Process Progress Reports Regulation Reporting Research Design Research Personnel Running Sample Size Series Site T-Lymphocyte Translational Research Transplantation Travel United States National Institutes of Health Universities Unmarried person Vaccination Viral Viral Antigens Virus Virus Diseases Visit Work adaptive immunity antiviral immunity cytokine design experience immune function medical schools meetings member novel novel vaccines programs research study symposium therapeutic vaccine

项目摘要

The lack of effective vaccines and therapeutic treatments for many viruses presents a heath concern of significant proportions. Host defenses against viruses require adaptive immune functions provided by both B cells and T cells, but the cellular and molecular processes that control the functions of these cells are incompletely understood. Although the persistence of viral antigens, the cytokine milieu in local microenvironments, the concentration and placement of immune cells in lymphoid and non-lymphoid organs, and the availability and type of costimulation can all dramatically affect the ultimate biological outcome of an immune response to virus infection or vaccination, it is unclear how these factors are controlled or how viruses manipulate each of these factors to evade or subvert immunity. These basic knowledge gaps limit our ability to rationally design new vaccines and to develop interventions to treat virus-mediated diseases. Therefore the overall goal of this U19 Program is to determine how various types of virus infections (chronic systemic, acute-systemic and acute-mucosal) affect the factors described above and lead to specific types of immune responses. In order to meet this goal, five labs with complementary expertise in human and mouse anti-viral immunology will work collaboratively to some of the key unresolved issues in anti-viral immunity. The major objectives of Core A are to provide administrative oversight and support for the program as a whole and for each of the individual projects, to provide biostatistics support for all the projects, to organize the external advisor visits, to organize yearly trips to the U19 conference and to organize monthly phone conferences and yearly face-to-face meetings of the investigators in each of the projects

许多病毒缺乏有效的疫苗和治疗性治疗表明，对大量的荒地关注。宿主防御病毒需要B细胞和T细胞提供的自适应免疫功能，但是控制这些细胞功能的细胞和分子过程是不完全理解的。尽管病毒抗原，局部微环境中的细胞因子环境，免疫细胞在淋巴机和非淋巴机构中的浓度和放置以及造型的可用性和类型都可以极大地影响每个因素对这些因素或对这些因素的最终影响，这些因素是对这些因素的最终因素，是对这些因素的影响，是对这些因素的影响，是对这些因素的影响。或颠覆免疫力。这些基本知识差距限制了我们合理设计新疫苗并开发干预措施以治疗病毒介导的疾病的能力。因此，该U19程序的总体目标是确定各种类型的病毒感染（慢性全身，急性 - 系统和急性粘膜）如何影响上述因素并导致特定类型的免疫反应。为了实现这一目标，五个具有人类和小鼠抗病毒免疫学专业知识的实验室将与抗病毒免疫中的一些关键未解决的问题进行协作。核心A的主要目标是为整个计划以及每个项目提供行政监督和支持，以为所有项目提供生物统计学支持，以组织外部顾问访问，以组织U19会议的年度旅行，并组织每月的电话会议和每年在项目中的每年一次的项目会议