Cognitive and Self-Regulatory Mechanisms of Obesity Study (COSMOS)

肥胖研究的认知和自我调节机制（COSMOS）

• 批准号: 9134132
• 负责人: Misty Hawkins
• 金额: $ 15.72万
• 依托单位: OKLAHOMA STATE UNIVERSITY STILLWATER
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2020-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9134132
• 关键词: Address; Aftercare; Area; Arts; Attention; Basic Science; Behavior; Behavior Therapy; Behavioral; Behavioral Medicine; Biological Markers; Body Weight decreased; Cardiovascular Physiology; Career Choice; Chronic; Clinical; Clinical Research; Clinical Trials; Cognition; Cognitive; Cognitive deficits; Control Groups; Data; Development; Diastolic blood pressure; Environment; Epidemic; Exhibits; Failure; Glycosylated hemoglobin A; Goals; Health; Health behavior; Hyperphagia; Individual; Informal Social Control; Interleukin-6; Intervention; K-Series Research Career Programs; Link; Maintenance; Memory; Mentored Patient-Oriented Research Career Development Award; Mentors; Modeling; NCI Scholars Program; Neuropsychological Tests; Neuropsychology; Obesity; Outcome; Pathway interactions; Patient Self-Report; Performance; Persons; Physiological; Psychologist; Psychology; Psychophysiology; Randomized; Randomized Clinical Trials; Randomized Controlled Trials; Research; Research Activity; Research Methodology; Research Personnel; Resources; Science; Scientist; Self-control as a personality trait; TNF gene; Testing; Training; Training Activity; Translational Research; Universities; Weight Gain; Work; base; cognitive function; college; design; distress tolerance; effective therapy; executive function; experience; follow-up; glycemic control; improved; inflammatory marker; innovation; meetings; mindfulness; neuropsychological; novel; obesity treatment; obesogenic; patient oriented research; patient population; pilot trial; prevent; programs; skills; standard care; statistics; successful intervention; therapy design; treatment group; treatment program; weight loss intervention; young adult

 DESCRIPTION (provided by applicant): This K23 award will allow Dr. Misty Hawkins, a clinical psychologist with expertise in behavioral medicine and obesity, to further develop into an independent investigator proficient in physiological, neuropsychological, and self-regulatory research methods and interventions that will allow her to study novel mechanisms of and treatments for obesity maintenance. She has a career interest in intervening on the neuropsychological factors related to obesity. Her research goal is to identify novel cognitive and self-regulatory mechanisms of obesity in this pilot trial which can then be targeted in larger RCTs to reduce obesity development or to maintain weight loss. Obesity continues to be a global epidemic, yet successful interventions for obesity are rare, with 80% of individuals in treatment programs being unsuccessful at achieving long-term weight loss. The training and research activities in this K23 application will allow her to examine the complexities of physiological dysregulation, cognitive deficits, and self-regulatory failure in an obesity treatmen study. The application proposes an intensive, 5-year program of mentored research and formal training activities to enhance Dr. Hawkins' skills and experience in: 1) basic research on and assessment of cognitive function; (2) assessment of obesity-related physiological changes; (3) research with patient populations; (4) advanced assessment of self-regulation (SR); and (5) the conduct of randomized clinical trials and advanced statistics. In the long term, Dr. Hawkins will apply these translational research skills to study targeted cognitive and self-regulation interventions as potentially effective treatments for persons with obesity who may exhibit cognitive deficits or chronic self-regulatory failure. The research component of this career development award is a clinical trial examining the impact of two different weight loss treatments on physiological markers, cognition, self- regulation, and health behaviors in 64 obese persons compared to 32 no-treatment controls. The specific aims are to: 1) Confirm that baseline obesity-related physiological dysregulation is linked to cognitive deficits, poorer self-regulation and obesogenic behaviors, 2) Demonstrate that the two treatment groups have greater improvements in biomarkers, cognition, SR, and obesogenic behaviors, less weight gain, and greater weight loss, and 3) Evaluate whether the acceptance-based treatment (ABT) group has greater improvements in biomarkers, cognition, SR, and obesogenic behaviors, less weight gain, and greater weight loss than the standard behavioral treatment group (SBT) from pre- to post-treatment and 1-year follow-up. Kent State University and its research partner Case Western Reserve University provide exceptional environments for Dr. Hawkins to gain the skills needed to achieve her goals. The training component uses academic resources including the College of Arts and Sciences, the Department of Psychology, and the Clinical Research Scholar Program. Dr. Hawkins' mentors are highly regarded scientists in the areas of obesity, neuropsychology, psychophysiology, and patient-oriented research.

 描述（由申请人提供）：该 K23 奖项将让在行为医学和肥胖方面具有专业知识的临床心理学家 Misty Hawkins 博士进一步发展成为一名 独立研究者，精通生理学、神经心理学和自我调节研究方法和干预措施，这将使她能够研究肥胖维持的新机制和治疗方法。她的职业兴趣是干预与肥胖相关的神经心理因素。在这项试点试验中确定新的肥胖认知和自我调节机制，然后将其作为更大的随机对照试验的目标，以减少肥胖的发展或维持体重减轻。肥胖仍然是一种全球流行病，但成功的肥胖干预措施很少见。 80%该 K23 应用程序中的培训和研究活动将使她能够检查肥胖治疗者应用程序中生理失调、认知缺陷和自我调节失败的复杂性。提出了一项为期 5 年的密集指导研究和正式培训活动计划，以增强霍金斯博士在以下方面的技能和经验：1）认知功能的基础研究和评估；（2）肥胖相关生理变化的评估；与患者一起研究（4）自我调节（SR）的高级评估；以及（5）随机临床试验和高级统计的进行 从长远来看，霍金斯博士将应用这些转化研究技能来研究有针对性的认知和自我调节干预措施。作为对可能表现出认知缺陷或慢性自我调节失败的肥胖症患者的潜在有效治疗方法，该职业发展奖的研究部分是一项临床试验，旨在研究两种不同的减肥疗法对生理标志、认知和自我调节的影响。和 64 名肥胖者的健康行为与 32 个未治疗对照组相比，具体目标是：1) 确认基线肥胖相关的生理失调与认知缺陷、较差的自我调节和肥胖行为有关，2) 证明两个治疗组在以下方面有更大的改善：生物标志物、认知、SR 和致肥胖行为、体重增加较少和体重减轻较多，以及 3) 评估基于接受的治疗 (ABT) 组在生物标志物、认知、SR 和肥胖行为方面是否有更大的改善从治疗前到治疗后以及 1 年随访，肯特州立大学及其研究合作伙伴凯斯西储大学为患者提供了与标准行为治疗组 (SBT) 相比的肥胖行为、体重增加更少和体重减轻更多。霍金斯博士获得实现其目标所需的技能，包括艺术与科学学院、心理学系和临床研究学者计划的学术资源。霍金斯博士的导师都是备受尊敬的科学家。肥胖症、神经心理学、心理生理学和以患者为导向的研究。