Research Capacity Building in Post Ebola Countries

埃博拉后国家的研究能力建设

• 批准号: 9229914
• 负责人: DONALD SAMUEL GRANT
• 金额: $ 5万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-22 至 2018-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9229914
• 关键词: Address; Allied Health Sciences; Applications Grants; Clinical Research; Clinical Trials; Collaborations; Conduct Clinical Trials; Country; Disease Outbreaks; Ebola virus; Ensure; Epidemic; Future; Goals; Government; Grant; Health Professional; Health Services; Health system; Hospitals; Indigenous; Infectious Diseases Research; Institution; Investments; Knowledge; Lassa Fever; Medicine; Patients; Preparation; Process; Public Health; Qualifying; Recording of previous events; Research; Research Infrastructure; Research Training; Sierra Leone; System; Training; Training Programs; Translational Research; Universities; Viral Hemorrhagic Fevers; Virus Diseases; base; clinical investigation; college; design; experience; implementation science; improved; medical schools; pandemic disease; prospective; skills

The recent Ebola epidemic exposed the fragility of Sierra Leone´s health system and highlighted the inadequate investments to date that are needed to support a well-functioning system capable of responding to a disease outbreak of this magnitude. To improve delivery of quality health services for patients with endemic viral hemorrhagic fevers (VHF) such as Lassa fever (LF), while strengthening capacity to conduct clinical trials during future epidemic VHF outbreaks such as Ebola, Sierra Leone must grow its pool of qualified health professionals with the methodological skills in implementation science and the conduct of clinical trials. We have designed a comprehensive planning grant proposal that will allow us to evaluate existing research capacity of our in-country partner organizations, while refining our strategies for best approaches to address gaps in that capacity. Based on our combined extensive knowledge and history of conducting VHF research in Sierra Leone; as well as nearly two-decades of experience in managing institutional research, training, and capacity-building grants; we propose our expected research training plan. Upon completion of the planning grant period we fully expect to submit a competitive proposal that responds to the goals of the FIC Global Infectious Disease Research Training Program (D43). We seek to substantially advance implementation science research capacity at Sierra Leone´s principal medical school, the University of Sierra Leone College of Medicine and Allied Health Sciences (COMAHS); as well as clinical trial infrastructure at the Kenema Government Hospital (KGH) through the proposed Partnership for Research in Emerging Viral Infections-Sierra Leone (PREVSL) [pronounced “Prev Sil”]. Our Specific Aim during the D71 Planning Grant period is to promote sustainable clinical and translation research capacity in Sierra Leone that addresses emerging viral diseases, specifically Ebola, Lassa, and other VHF, that have regional and global pandemic potential by: 1) Conducting an assessment of existing research training capacity at COMAHS and its partnering institutions, in preparation of submission of a (D43); 2) Reinforcing administrative, managerial, and research collaboration ties between COMAHS and the training partners proposed; and 3) Finalizing a list of prospective trainee candidates and ensure the establishment of a recruitment and selection process for future trainees from Sierra Leone. Our subsequent D43 training program will consist of a combination of (1) long-term Masters training in clinical investigation or public health at Vanderbilt; (2) short- to medium-term clinical trial management training that reinforces south-south collaborations and builds regional networks; (3) short and long-term capacity building in health services implementation science research; and (4) sustainable, indigenous capacity building at COMAHS for the management and administration of future research grant opportunities.

最近的埃博拉流行病暴露了塞拉利昂的卫生系统的脆弱性 并强调了迄今为止所需的投资不足，这些投资是支持功能齐全的系统 能够应对这种疾病的爆发。改善优质保健服务的交付 对于内在病毒出血狂（VHF）的患者，例如Lassa Fever（LF），同时加强 在未来的流行病爆发（例如埃博拉病毒）中进行临床试验的能力，塞拉利昂必须增长 其合格的卫生专业人员库具有实施科学方面的方法论技巧和 进行临床试验。 我们设计了一项全面的计划赠款建议，使我们能够评估现有研究 我们的国内合作伙伴组织的能力，同时完善我们的策略以解决最佳方法 以这种身份的差距。根据我们在进行VHF研究的综合知识和历史 塞拉利昂；以及管理机构研究，培训和 能力建设赠款；我们提出了预期的研究培训计划。计划完成后 我们完全期望提交一项竞争性建议，以响应FIC全球目标 传染病研究培训计划（D43）。 我们试图在塞拉利昂的校长中大大提高实施科学研究能力 医学院，塞拉利昂大学医学院和盟军健康科学学院（COMAHS）；作为 以及通过拟议的Kenema政府医院（KGH）的临床试验基础设施 新兴病毒感染研究的研究伙伴关系 - 塞拉利昂（PREVSL）[发音为“ Prev Sil”]。 我们在D71计划赠款期间的具体目标是促进可持续的临床和翻译 塞拉利昂的研究能力解决了新兴病毒疾病，特别是埃博拉病毒，拉萨和其他 VHF，具有区域和全球流行潜力：1）对现有研究进行评估 在准备提交（D43）的情况下，在COMAHS及其合作机构的培训能力； 2）加强COMAH与培训之间的行政，管理和研究合作关系 合作伙伴提议； 3）最终确定准培训人员候选人的清单，并确保建立 来自塞拉利昂的未来学员的招聘和选择过程。 我们随后的D43培训计划将包括（1）临床长期硕士培训的组合 范德比尔特的调查或公共卫生； （2）短期至中期临床试验管理培训 加强南南的合作并建立区域网络； （3）短期和长期能力建设 卫生服务实施科学研究； （4）可持续的土著能力建设 用于管理和管理未来研究赠款机会的COMAH。