Development of Blood Pressure Imager

血压成像仪的开发

• 批准号: 8936177
• 负责人: Natesa Pandian
• 金额: $ 38.45万
• 依托单位: TUFTS UNIVERSITY BOSTON
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-30 至 2017-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8936177
• 关键词: Accounting; Acute; Affect; Ambulatory Blood Pressure Monitoring; Animal Model; Arteries; Blood Pressure; Blood Pressure Monitors; Body mass index; Calibration; Car Phone; Caring; Categories; Clinic; Clinical; Computer software; Data; Data Analyses; Data Quality; Development; Devices; Diastolic blood pressure; Education; Engineering; Environment; Equipment; Evaluation; Funding Opportunities; Goals; Health; Heart; Home environment; Hour; Human; Hypertension; Image; India; Individual; Inpatients; Institutes; International; Lead; Location; Massachusetts; Measurement; Measures; Medical; Minor; Modeling; Modification; Monitor; Motion; Obesity; Operative Surgical Procedures; Optics; Oryctolagus cuniculus; Participant; Patients; Power Sources; Research Personnel; Resolution; Resources; Rest; Rubber; Rural Population; Silicon; Skin; Sphygmomanometers; Surface; System; Tactile; Technology; Testing; Thick; Time; TimeLine; Ultrasonography; Universities; Urban Population; Validation; Variant; Wearable Computer; Work; Wrist; arterial stiffness; base; cohort; design; hemodynamics; innovation; medical schools; miniaturize; new technology; novel; pressure; product development; public health relevance; radial artery; research study; respiratory; response; sensor; signal processing; simulation; soft tissue; subcutaneous; transmission process

 DESCRIPTION (provided by applicant): Development of Blood Pressure Imager We propose a new technology to measure blood pressure (BP) called the Blood Pressure Imager (BPI) that does not require cuffs or expensive equipment, and that can be used by untrained individuals. The primary innovation rests on the application of cutting-edge optical tactile sensor technology to the basic observation that blood pressure (BP) has a direct relationship to the outward force on the arterial wall, which, in turn, affects the deformation and forces imposed on the tactile sensor array by the skin surface above, particularly at locations such as the region above the radial artery. By integrating high-resolution GelSight optical tactile sensor patch together with signal processing software, BPI can provide precise measurement of skin surface motions and forces exerted by the underlying pressure wave and provide an accurate measure of systolic and diastolic blood pressure. The development and validation of the BPI will be a collaborative project between researchers at the Massachusetts Institute of Technology and Tufts University School of Medicine. The specific aims of the proposed product development include (1) To optimize existing portable BPI to measure blood pressure accurately in arterial phantoms; (2) To test and further optimize the portable BPI in animal models; (3) To miniaturize the BPI into a wearable device that will connect with mobile phones; (4) To validate the wearable BPI against intra-arterial blood pressure in a dynamic clinical setting; and (5) To validate the wearable BPI i clinic and home/low resource environments. The advantages of BPI over the existing devices are: (1) The BPI will be a cuff-less device that can used by untrained individuals; (2) It will provide instantaneous BP continuously over time and a direct measure of systolic and diastolic blood pressure; (3) It will measure BP over multiple heart beats and respiratory cycles to provide accurate measure of BP and valuable information on beat-to-beat BP variability; (4) It will be a novel wearable device that can be integrated with mobile phones and the data can be transferred instantly over low- bandwidth cellular connection for online/remote management of hypertension; (5) With no moving parts and built from off-the-shelf components, connected to existing mobile phones, and battery-driven, the BPI will be affordable and not require additional power source; (6) With relatively minor design modifications, the BPI could provide 24-hour ambulatory monitoring of BP and has potential for use in acute, dynamic inpatient settings as an alternative to invasive monitoring.

 描述（由应用提供）：流血成像师的开发我们提出了一种新技术来测量称为血压成像仪（BPI）的血压（BP），该技术不需要袖口或昂贵的设备，未经训练的人可以使用。主要的创新基于将尖端光学触觉传感器技术应用到基本观察中，即血压（BP）与动脉壁上的外部力有直接关系，而动脉壁上的外部力量又影响了上面的皮肤表面上的触觉传感器阵列的变形和力，尤其是在界面上方的区域，尤其是在径向上方的区域。通过将高分辨率凝胶光学触觉传感器贴片与信号处理软件结合在一起，BPI可以精确地测量皮肤表面运动和由潜在压力波施加的力，并提供对收缩压和舒张压的准确测量。 BPI的开发和验证将是马萨诸塞州技术学院和塔夫茨大学医学院研究人员之间的合作项目。拟议产品开发的特定目的包括（1）优化现有的便携式BPI，以准确测量动脉幻象的血压； （2）测试并进一步优化动物模型中的便携式BPI； （3）将BPI微型化成可穿戴的设备，该设备将与手机连接； （4）在动态临床环境中验证可穿戴的BPI针对动脉内血压； （5）验证可穿戴的BPI I临床和家庭/低资源环境。 BPI比现有设备的优点是：（1）BPI将是无袖口的设备，未经训练的个体可以使用； （2）随着时间的流逝，它将连续提供瞬时BP，并直接测量收缩压和舒张压； （3）它将在多个心跳和呼吸周期上测量BP，以提供BP的准确测量，以及关于Beat-Beat BP变异性的宝贵信息； （4）这将是一种可与手机集成的新型可穿戴设备，并且可以通过低频带宽的蜂窝连接转移数据，以在线/远程管理高血压管理； （5）没有运动部件，并且由现有的组件建造，连接到现有的手机以及电池驱动的，BPI将负担得起，不需要额外的电源； （6）BPI经过相对较小的设计修改，可以提供24小时的BP卧床监测，并具有用于急性动态住院设置的潜力，可作为入侵监测的一种替代方法。