Oncology Research Training Grant

肿瘤学研究培训补助金

• 批准号: 9053446
• 负责人: PAVAN REDDY
• 金额: $ 34.31万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1980
• 资助国家: 美国
• 起止时间: 1980-07-01 至 2018-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9053446
• 关键词: Grant; Research Training; oncology

DESCRIPTION (provided by applicant): The Oncology Research Training Program has been in existence for 30 years and was developed with the primary goal of preparing physician-trainees for careers in academic oncology. The rationale for training in oncology research is three fold: (1) Cancer remains the leading cause of morbidity and mortality in the US; (2) There is a need to maintain momentum that has been achieved in our fundamental understanding of carcinogenesis (particularly in the molecular pathogenesis of cancer); and (3) There is a need to translate progress gained in the laboratory to the development of new strategies for the diagnosis, treatment, and prevention of cancer. Research training themes of the Program are based on the investigative interest and expertise of 27 well-established and extramurally-funded faculty members in the Division of Hematology/Oncology in the Department of Internal Medicine and the Comprehensive Cancer Center of the University of Michigan (UMCCC) (which includes faculty with appointments in other clinical and basic science departments). These research training themes in the current application are: (1) Molecular-genetic mechanisms of neoplastic transformation, aberrant signaling, and metastasis, (2) Biomarkers in cancer prevention and therapy; (3) Cancer stem cells; (4) Molecular targets of drug discovery and experimental therapeutics of cancer; and (5) Immunological approaches to cancer therapy. Trainees will be exposed to research opportunities across the spectrum from basic laboratory research to translational and clinical research, with the long-term goal of establishing an academic career in cancer research in one of these areas and being paired with an appropriate mentor. It is expected that trainees selected for this program will spend 2- 3 years in the laboratory or relevant clinical research environment under the direct supervision of a training program faculty mentor and will develop skills in: (1) Identifying testable hypotheses that address important questions in oncology research; (2) Acquiring the necessary technical expertise to test the hypotheses identified; (3) Critically evaluating the data generated; and (4) Developing the necessary skills of written and oral communication to promulgate conclusions made. The majority of trainees will have an MD degree or MD/PhD degrees, 3 years of house officer training in Internal Medicine and a year of clinical subspecialty training in medical oncology/hematology. MD trainees with limited prior research experience will be encouraged to participate in an intensive 3 month postdoctoral research training program (directed and taught by Training Program faculty) to introduce them to important concepts in cellular and molecular biology. The ultimate goal of the program is to prepare trainees for careers in academic oncology as independent faculty members of schools of medicine at research universities.

描述（由申请人提供）：肿瘤学研究培训计划已经存在了30年，其发展是为了为学术肿瘤学职业准备医师培训者的主要目标。肿瘤学研究培训的基本原理是三倍：（1）癌症仍然是美国发病率和死亡率的主要原因； （2）需要维持我们对癌变的基本理解（尤其是在癌症的分子发病机理）中实现的动力； （3）有必要将实验室中获得的进度转化为开发癌症诊断，治疗和预防的新策略。该计划的研究培训主题是基于内科医学系血液学/肿瘤学系和密歇根大学（UMCCC）综合癌症中心（包括在其他临床和基础科学部门任命的教师）的血液学/肿瘤学系的研究兴趣和专业知识。当前应用中的这些研究训练主题是：（1）肿瘤转化，异常信号传导和转移的分子基因机制，（2）预防癌症预防和治疗中的生物标志物； （3）癌症干细胞； （4）药物发现和癌症实验疗法的分子靶标； （5）癌症治疗的免疫学方法。从基础实验室研究到转化和临床研究，学员将接触整个范围内的研究机会，其长期目标是在其中一个领域建立学术生涯，并与适当的导师配对。预计为该计划选择的学员将在培训计划教师的直接监督下在实验室或相关临床研究环境中度过2至3年，并将在以下方面发展技能：（1）确定可检验的假设，以解决肿瘤学研究中重要问题的可检验假设； （2）获取必要的技术专业知识来检验所确定的假设； （3）批判性评估生成的数据； （4）将书面和口头交流的必要技能发展为颁布的结论。大多数学员将拥有MD学位或MD/PHD学位，内科医学的3年内政官培训以及一年的医学肿瘤学/血液学临床专科培训。将鼓励具有有限的先前研究经验的MD学员参加一项3个月的密集研究培训计划（由培训计划教师指示和教授），以将其介绍给细胞和分子生物学中的重要概念。该计划的最终目的是为学术肿瘤学的职业学员准备研究学院的独立教职员工。