Study of Women's Health Across the Nation (SWAN) V: Coordinating Center

全国妇女健康研究 (SWAN) V：协调中心

• 批准号: 9108798
• 负责人: Maria Mori Brooks
• 金额: $ 246.22万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-30 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9108798
• 关键词: Address; Adopted; Adrenal hormone preparation; Age; Aging; Ancillary Study; Archives; Area; Biological; Biological Assay; Body Composition; Body Size; CLIA certified; Calendar; Cardiovascular system; Characteristics; Chinese People; Chronology; Clinic Visits; Clinical; Cohort Studies; Collaborations; Communities; Complex; Computer software; Creativeness; Data; Data Collection; Data Set; Databases; Development; Disease; Documentation; Enrollment; Ensure; Environment; Epidemiologic Studies; Epidemiology; Ethnic Origin; Fostering; Foundations; Genitourinary system; Health; Hemostatic function; Hispanics; Hormonal Change; Hormones; Hour; Housing; Inflammation; Institution; Investigation; Japanese Population; K-Series Research Career Programs; Knowledge; Laboratories; Lead; Leadership; Life Experience; Link; Longitudinal Studies; Manuscripts; Measures; Menopause; Mental Health; Methodology; Methods; Monitor; Movement; Natural History; Nature; Outcome; Ovarian; Participant; Pattern; Perimenopause; Personal Satisfaction; Physical Function; Physiological; Positioning Attribute; Postmenopause; Premenopause; Preparation; Prevention; Prevention program; Productivity; Protocols documentation; Public Health Schools; Publications; Quality Control; Race; Reading; Reporting; Reproductive Health; Research Infrastructure; Research Personnel; Resources; Risk Factors; Role; Secure; Sex Functioning; Sexual Health; Site; Sleep; Socioeconomic Status; Source; Specimen; Statistical Methods; Strategic Planning; Support System; Symptoms; System; Techniques; Technology; Time; Universities; Vagina; Vasomotor; Visit; Woman; Women' s Health; Writing; actigraphy; adipokines; age related; base; bone; clinical practice; clinical research site; clinically relevant; cognitive function; cohort; computerized; data management; design; disorder risk; experience; follow-up; improved; innovation; insight; longitudinal analysis; meetings; middle age; psychologic; psychosocial; public health relevance; racial and ethnic; racial difference; repository; reproductive senescence; response; skeletal; socioeconomics; statistical center; treatment program

DESCRIPTION (provided by applicant): This is the amended competing renewal application of the Study of Women's Health Across the Nation (SWAN), a 7-site longitudinal cohort study initiated in 1994 in response to RFA AG-94-002. SWAN was mandated "to characterize the chronology of the biological and psychosocial antecedents and sequelae of the menopausal transition (MT) and the effect of this transition on subsequent health and risk factors for age- related disease", and to extend this information from White women to "...the range of peri-menopausal experiences in women of other racial/ethnic background(s)." A total of 3302 Black, Chinese, Japanese, Hispanic and White women were enrolled, with 78% completing up to 13 visits spanning the premenopause to early post-menopause (PM). Thus far, SWAN has described the natural history of the MT -- its timing, patterns of hormonal changes, and symptoms and factors related to them - and their relation to disease risk indicators. During SWAN V, we will extend observations through the late PM, a necessary step to assess the impact of the MT on age-related diseases. Our specific aims are to: 1) complete the characterization of the natural history of reproductive aging through the late PM; 2) evaluate the impact of reproductive aging through the late PM on health outcomes clinically relevant to women in their 60s and 70s, including: cognitive and physical function, psychological well-being, sleep, bone and cardiometabolic health, urogenital symptoms, sexual function and vaginal health; and 3) identify potential underlying mechanisms linking reproductive aging and health by assessing the relation of inflammation, hemostasis and adipokines to the occurrence and progression of biological, functional and clinical outcomes and delineating the interrelationships of body size and composition, race/ethnicity and socioeconomic status with these outcomes. The SWAN V Core protocol will be completed at 7 study sites, with bone and cardiovascular studies at 4 sites and actigraphy studies in a subset of women at all sites. Longitudinal specimens from the SWAN Repository will enable characterization of skeletal markers, adrenal hormones, hemostasis, inflammation, and adipokines across the MT into PM. The Coordinating Center will provide the necessary organizational infrastructure, statistical resources, and timely dissemination of high quality SWAN data. The CLIA-certified Central Laboratory will perform or coordinate with other laboratories to provide accurate, high volume assays, adopting new methods as needed to provide state- of-the-art data. SWAN is uniquely positioned to fill important scientific gaps in understanding of the impact of the MT on women's health in their 60s and 70s and to facilitate the application of new knowledge to clinical practice. With 1.5 decades of both calendar time and "menopause time", SWAN V can disaggregate the contributions of aging and the MT to women's health, address difficult and critical questions about the temporal nature of MT-disease associations, assess differences by race/ethnicity, and provide insights into modifiable factors relevant to the design of innovative prevention and treatment programs for aging women.

描述（由申请人提供）：这是对全国妇女健康研究（SWAN）的竞争性更新的应用，这是一项针对RFA AG-94-002的7个地点纵向队列研究。斯旺被授权“表征了绝经过渡（MT）的生物学和心理社会前因和后遗症的年代学，以及这种过渡对随后的与年龄相关疾病的健康和风险因素的影响”，并将这些信息从白人女性扩展到………………在其他种族/其他种族/其他种族背景（S）的范围”。总共招募了3302名黑色，中国，日本，西班牙裔和白人妇女，其中78％的人完成了13次访问，涉及前期早期到少年后（PM）。到目前为止，天鹅已经描述了MT的自然历史 - 其时间，激素变化的模式以及与之相关的症状和因素 - 以及它们与疾病风险指标的关系。在天鹅v期间，我们将通过PM晚期进行观察，这是评估MT对年龄相关疾病的影响的必要步骤。我们的具体目的是：1）完成PM晚期生殖老化的自然历史的表征； 2）评估PM晚期生殖老化对与60年代和70年代女性有关的健康结果的影响，包括：认知和身体机能，心理健康，睡眠，骨骼和心脏代谢健康，泌尿生殖器症状，性功能和阴道健康； 3）通过评估炎症，止血和脂肪因子与生物学，功能和临床结局的发生和进展，并划定身体大小，种族/种族/族裔和社会经济状况的相互关系来确定与生殖老化和健康联系的潜在潜在机制。天鹅V核心方案将在7个研究地点完成，在所有地点的一部分女性中，在4个地点进行骨和心血管研究。天鹅储存库的纵向标本将使骨骼标记，肾上腺激素，止血，炎症和脂肪因子跨MT横跨PM进行表征。协调中心将提供必要的组织基础设施，统计资源以及及时传播高质量的天鹅数据。经过CLIA认证的中央实验室将与其他实验室进行或协调，以提供准确，大量的测定法，并根据需要采用新方法来提供状态数据。天鹅在理解60年代和70年代妇女对妇女健康的影响方面的重要科学空白方面处于独特状态，并促进将新知识应用于临床实践。 Swan V有1.5年的日历时间和“更年期时间”，可以分解衰老和MT对妇女健康的贡献，解决有关MT-Disease关联的时间性质的困难和关键问题，评估种族/民族的差异，并将与可修改的因素相关，使其与针对预防预防和治疗女性设计的可修改因素相关。