Methamphetamine Research Program at Meharry Medical College

梅哈里医学院甲基苯丙胺研究项目

基本信息

批准号：
8982228
负责人：
CLIVEL G. CHARLTON
金额：
$ 45.37万
依托单位：
MEHARRY MEDICAL COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-04-15 至 2018-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8982228
关键词：
Accident and Emergency department Acute Address Admission activity Anxiety Applications Grants Award Awareness Basic Science Behavior Therapy Behavioral Chronic Clinic Clinical Community Medicine Country Dementia Development Disadvantaged Dopamine Drug Addiction Drug Rehabilitation Centers Drug abuse Educational process of instructing Environment Faculty Family Practice Goals Grant HIV Health Professional Income Individual Industry Investigation Journals Lead Life Link Medical Medical Students Membrane Microdomains Metabolic Pathway Methamphetamine Methamphetamine dependence Mission Molecular Neurobiology Neurosciences Research Pathway interactions Patient Self-Report Peer Review Pharmaceutical Preparations Pharmacological Treatment Pilot Projects Poverty Primary Health Care Publications Publishing Research Research Personnel Residencies Role Rural Scientist Self Medication Series Signal Transduction Subgroup Substance Use Disorder Tennessee Testing Training Training Programs Underserved Population Virus Diseases Work addiction base career development college curriculum enhancement dopamine transporter education research effective intervention ethnic minority population experience graduate student health disparity improved insight interest medical schools methamphetamine abuse methamphetamine effect methamphetamine exposure methamphetamine use minority student neuron loss novel primary care setting programs racial and ethnic screening and brief intervention screening, brief intervention, referral, and treatment skills substance misuse symposium therapeutic target

项目摘要

DESCRIPTION (provided by applicant): The long-range goal of the proposed DIDARP program described in this application is to continue to increase the capacity of Meharry Medical College to conduct rigorous research in substance use disorders with an [ emphasis on health disparities and underserved populations. The research program will seek to understand the molecular underpinnings of acute and chronic methamphetamine (METH) exposure alone and in conjunction with human immunodeficiency virus (HIV) infection. We also plan to strengthen pur intellectual environment and enhance the interest levels of trainees and faculty in drug abuse research. New for this j application is the proposal to introduce training on screening and brief interventions for substance misuse to medical students, residents and faculty in the Family and Community Medicine clinics. The Specific Aims of the Meharry Medical College DIDARP Program during the next five years are: 1. To publish at least 20 or more peer-reviewed publications in high-impact journals in drug abuse research; 2. To submit 5 or more grant applications in drug abuse research by Year-03 of the award period; | 3. To acquire 3 or more investigator-initiated awards by the end of year-05; and 4. To stimulate additional faculty and trainee interest in drug abuse research by curricula enhancement, ' seminars and symposia. . Three projects are proposed, one primary proposal and two pilot projects. In the primary project, Dr. CV. ] Dash will seek to understand the link between METH abuse and HIV infection. In the first pilot project, Dr. J. Shawn Goodwin will study how METH abuse alters dopamine signaling by altering the dopamine transporter residency in lipid rafts. In second pilot project, Dr. Khilber and her collaborators which includes the PI and the Chair of Family and Community Medicine, Dr. Roger Zoorob, will test the effects of a tiered training program on screening, brief intervention and referral to treatment (SBIRT) for substance misuse fo

描述（由申请人提供）：本申请中描述的拟议 DIDARP 计划的长期目标是继续提高梅哈里医学院对物质使用障碍进行严格研究的能力，重点关注健康差异和服务不足的人群。该研究计划将寻求了解急性和慢性甲基苯丙胺（METH）单独暴露以及与人类免疫缺陷病毒（HIV）感染相关的分子基础。我们还计划加强纯粹的知识环境，提高学员和教师对药物滥用研究的兴趣水平。该申请的新内容是提议向家庭和社区医学诊所的医学生、住院医师和教职人员介绍药物滥用筛查和简短干预措施的培训。梅哈里医学院 DIDARP 计划未来五年的具体目标是： 1. 在药物滥用研究的高影响力期刊上发表至少 20 篇或更多同行评审出版物； 2. 在资助期的第03年之前提交5项或以上药物滥用研究资助申请； | 3. 05年底前获得3项及以上研究者发起奖励； 4. 通过加强课程、研讨会和专题讨论会，激发更多教师和学员对药物滥用研究的兴趣。。提出了三个项目，其中一个是初步提案，两个是试点项目。在主要项目中，CV 博士。 ] Dash 将寻求了解冰毒滥用与艾滋病毒感染之间的联系。在第一个试点项目中，J. Shawn Goodwin 博士将研究冰毒滥用如何通过改变脂筏中的多巴胺转运蛋白驻留来改变多巴胺信号传导。在第二个试点项目中，Khilber 博士和她的合作者（包括 PI 和家庭和社区医学主席 Roger Zoorob 博士）将测试分级培训计划对筛查、简短干预和转诊治疗 (SBIRT) 的效果对于物质滥用