Life-course pathways linking adolescent childbearing to chronic conditions: A pilot study to reinforce research and health system capacity in Northeast Brazil

将青少年生育与慢性病联系起来的生命历程路径：一项旨在加强巴西东北部研究和卫生系统能力的试点研究

• 批准号: 9232027
• 负责人: SAIONARA M A CAMARA
• 金额: $ 16.59万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9232027
• 关键词: 17 year old; Academic Training; Address; Adolescence; Adolescent; Adult; Attitude; Biological; Biological Markers; Brazil; Budgets; Childbirth; Chronic; Chronic Disease; Chronic lung disease; Clinical; Collaborations; Communities; Country; Data; Development; Diabetes Mellitus; Disadvantaged; Discipline of Nursing; Disease; Doctor of Philosophy; Economics; Education; Elderly; Epidemiologic Studies; Epidemiology; Ethics; Family; Fertility; Fostering; Foundations; Future; Gender; Generations; Health; Health Services; Health system; Hypertension; Income; Inequality; Institution; Interview; Knowledge; Laboratory Research; Latin America; Learning; Life; Life Cycle Stages; Link; Long-Term Effects; Low Birth Weight Infant; Measurement; Measures; Modification; Neonatal; Newborn Infant; Outcome; Pathway interactions; Physical Function; Physical therapy; Physiological; Physiology; Pilot Projects; Policies; Population; Portuguese; Postpartum Period; Poverty; Pregnancy; Pregnancy Trimesters; Pregnancy in Adolescence; Pregnant Women; Premature Birth; Psychology; Public Health; Questionnaires; Reporting; Research; Research Infrastructure; Research Personnel; Retrospective Studies; Risk; Rural; Rural Community; Sampling; Scientific Advances and Accomplishments; Time; Training; Training and Infrastructure; United States; Universities; Woman; Women' s Health; Work; child bearing; cohort; cultural values; disability; evidence base; girls; health care service; higher education; improved; innovation; international partnership; middle age; next generation; older women; pregnant; pregnant teen; programs; psychologic; public health intervention; reproductive; research study; social; social norm; socioeconomics; student training; systems research; unintended pregnancy; urban area; young woman

Project Summary: This project has two principal objectives: 1) Improve health system and research capacity in the community of Santa Cruz, which is located in the region of Northeast Brazil and 2) Apply that capacity in order to conduct epidemiological research investigating pathways that may explain how and why adolescent childbirth is associated to chronic conditions and mobility loss in middle-aged and older women. Such information is vital to developing preventative public health interventions to address non-communicable diseases across the life-course. Lessons learned from this research would add to the research evidence-base for policy and action on adolescent pregnancy and, more broadly, women's health in Latin America. Specifically, this project aims to: 1) Train students from the Santa Cruz campus of the Federal University of Rio Grande do Norte (Brazil) to conduct epidemiological interviews, collect biological samples, and take anthropometric and clinical measures. It will also provide in-depth, specialized training on ethical research conduct when working with pregnant and adolescent women; 2) Develop and validate epidemiological questionnaires adapted to a low-education, rural, adolescent, Portuguese-speaking population; 3) Prospectively follow a pilot cohort of adolescent and adult women, pregnant for the first time, from the 1st trimester of pregnancy to 6-weeks postpartum. This pilot would collect questionnaire data (baseline), clinical measurements, and biomarker concentrations (baseline, 3rd trimester, 6-weeks postpartum). The proposed pilot study, which is the 3rd study aim, will lay the foundation for a more expansive and comprehensive research program investigating hypothesized mechanisms behind previously documented associations between adolescent childbirth and poor later-life health. Overall, the capacity built and sustained from this project will contribute to advancing health research in one of the most underserved regions of Brazil. It will provide training to the next generation of Brazilian researchers and establish long-term networks between Brazilian and United States researchers.

项目摘要：该项目有两个主要目标：1）提高卫生系统和研究能力 在位于巴西东北地区的圣克鲁斯社区中，2）在 为了进行流行病学研究调查途径，以解释青少年的方式以及为什么 分娩与中年和老年妇女的慢性病和流动性丧失有关。这样的 信息对于制定预防性公共卫生干预措施至关重要 整个生命过程中的疾病。从这项研究中学到的经验教训会增加研究证据基础 为了对青少年怀孕以及更广泛的拉丁美洲妇女健康的政策和行动。 具体来说，该项目的目的是：1）培训来自里约热内卢联邦大学圣克鲁斯校园的学生 格兰德·诺·北（Grande Do Norte）（巴西）进行流行病学访谈，收集生物学样本并接受 人体测量和临床指标。它还将提供深入的，专门的道德研究培训 与怀孕和青春期妇女一起工作时进行行为； 2）发展和验证流行病学 调查表适合于低教育，农村，青少年，讲葡萄牙语的人口； 3） 前瞻性地跟随青少年和成年妇女的飞行员队列，这是第一次怀孕 怀孕的妊娠到产后6周。该飞行员将收集问卷数据（基线），临床 测量和生物标志物浓度（基线，三个月，产后6周）。提议 试点研究是第三研究的目标，将为更广泛，更全面的基础奠定基础 研究计划研究了先前记录的关联背后的假设机制 在青少年分娩和晚期健康状况之间。总体而言，从中建立和维持的能力 项目将有助于推进巴西服务最不足的地区之一的健康研究。会 向下一代巴西研究人员提供培训，并在之间建立长期网络 巴西和美国研究人员。