Monochromatic 222 nm UV light: Development of a safe, cost-effective technology for the efficient reduction of bacterial and viral infection and transmission

单色 222 nm 紫外线：开发安全、经济高效的技术，有效减少细菌和病毒的感染和传播

基本信息

批准号：
9140848
负责人：
DAVID JONATHAN BRENNER
金额：
$ 15万
依托单位：
EDEN PARK ILLUMINATION, INC.
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-03-15 至 2017-03-14
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Drug resistant bacteria, such as MRSA, and airborne-transmitted microbes, such as influenza and TB, together present major health issues both in the developed and the developing world, with major health care and economic consequences. Recent research from Columbia University Medical Center demonstrated that single- wavelength far-UVC photons can kill bacteria and viruses while it cannot penetrate either the human stratum corneum (the outer dead-cell skin layer), nor the ocular cornea, nor the corneal tear-film layer, nor even the cytoplasm of individual human cells. In particular, the results teste both in vitro and in vivo have shown that several far-UVC wavelengths (such as 207 and 222 nm) are as efficient as conventional mercury containing germicidal UV lamp in inactivating both drug-resistant bacteria (e.g. MRSA) and viruses (e.g. H1N1), but these two far UVC wavelengths induce no damage to skin or to eyes, for a wide range of clinical endpoints, in contrast to a conventional broad-spectrum germicidal lamp. In this program, the team of Columbia University and Eden Park Illumination propose a novel, efficient disinfection tool which can be scalable and affordable. The team will develop uniform and flat lamps having anti-microbial advantages over conventional cylindrical UV lamps, but without the safety hazards. Eden Park have commercialized a new generation of UV light tiles with a patented microcavity plasma technology, producing lamps with a scalable, slim form factor for uniformly treating large surfaces. Based on confinement of low temperature plasma within large arrays of microcavities, this technology is ideally-suited for the efficient, inexpensive production of excimer-based 222 nm UV lamp. The technology of a monochromatic excimer lamp emitting 222 nm UV radiation will have two initial applications: 1) reducing surgical site infections, in which 222 nm photons will continuously illuminate the wound during surgery, and 2) minimizing airborne transmission of microbes such as TB and influenza, in which whole-room illumination will be used. Both have been successfully demonstrated with conventional germicidal lamps but widespread use has been limited due to the associated health hazards of conventional lamps. The Phase I Project Aims are first, to design and develop 222 nm microplasma UV flat lamp optimized for this germicidal application, and second, to use the lamp to demonstrate effective germicidal properties. The first Aim will involve design and optimization of a microplasma-based monochromatic far-UVC flat lamp optimized for germicidal applications, with the milestone of a 222 nm flat UV lamp without higher wavelength "contaminants", and with a lamp structure and gas mixture optimized for long lifetime. The second Aim is to demonstrate the efficacy of this 222 nm microplasma flat lamp for anti-bacterial efficiency in an in vivo wound model and for anti-viral efficiency in an airborne aerosol model. The milestones here are to demonstrate appropriate levels of MRSA killing in a murine model of surgical site infection, and appropriate levels of H1N1 influenza virus killing in an airborne aerosol model.

描述（由适用提供）：抗药性细菌，例如MRSA和空气传播的微生物，例如影响力和结核病，同时介绍了发达国家和发展中国家的重大健康问题，以及重大的医疗保健和经济后果。哥伦比亚大学医学中心的最新研究表明，单波长远-UVC的照片可以杀死细菌和病毒，而它无法穿透人类角膜（外部死细胞皮层），也无法穿透眼角膜，也无法渗透到人类人类细胞的细胞质量。特别是，结果在体外和体内均可表明，几个远处的波长（例如207和222 nm）与含有杀菌紫外线的常规汞含量一样有效临床终点，与常规的广谱粒度灯相反。在该计划中，哥伦比亚大学和伊甸园照明提案的团队是一种新颖，有效的消毒工具，可以扩展和负担得起。该团队将开发出比传统圆柱紫外线灯具有抗菌优势的均匀和平灯，但没有安全危害。伊甸园公园（Eden Park）将新一代的紫外线瓷砖商业化，并具有专利的微型腔等离子体技术，生产具有可扩展，纤细外形的灯，可均匀地处理大型表面。基于低温等离子体在大型微腔内的限制，该技术非常适合于高效，廉价地生产基于Impimer的222 nm UV灯。赋予222 nm UV辐射的单色振兴灯的技术将有两个初步应用：1）减少手术现场感染，其中222 nm Photosons将继续照亮手术期间的伤口，而2）将诸如TB和影响的空气生物传播（如TB和影响）最小化，将其全部用于整个房间。两者都通过常规杀菌灯成功证明，但是由于常规灯的健康危害，宽度的使用受到限制。第一阶段项目的目的是首先设计和开发针对这种杀菌应用优化的222 nm微质量紫外线，其次是使用灯来证明有效的杀菌特性。第一个目的将涉及设计和优化用于杀菌应用优化的基于微质量的单色远远紫外线扁平灯，并具有222 nm扁平紫外线的里程碑，没有更高的波长“污染物”，并且具有长期优化的灯泡结构和气体混合物。第二个目的是证明这款222 nm微质量平灯灯在体内风模型中对抗细菌效率的效率，并在机源性气溶胶模型中对抗病毒效率的效率。这里的里程碑是在手术部位感染的鼠模型中证明了适当水平的MRSA杀伤水平，并且适当水平的H1N1影响了空中气溶胶模型中的病毒杀死。

项目成果

期刊论文数量（4）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Far-UVC light: A new tool to control the spread of airborne-mediated microbial diseases.

DOI：
10.1038/s41598-018-21058-w
发表时间：
2018-02-09
期刊：
Scientific reports
影响因子：
4.6
作者：
Welch D;Buonanno M;Grilj V;Shuryak I;Crickmore C;Bigelow AW;Randers-Pehrson G;Johnson GW;Brenner DJ
通讯作者：
Brenner DJ

Germicidal Efficacy and Mammalian Skin Safety of 222-nm UV Light.

DOI：
10.1667/rr0010cc.1
发表时间：
2017-04
期刊：
Radiation research
影响因子：
3.4
作者：
Buonanno M;Ponnaiya B;Welch D;Stanislauskas M;Randers-Pehrson G;Smilenov L;Lowy FD;Owens DM;Brenner DJ
通讯作者：
Brenner DJ