A Pilot Investigation of Network-Informed Personalized Treatment for Eating Disorders versus Enhanced Cognitive Behavioral Therapy and Dynamic Mechanisms of Change

饮食失调的网络信息个性化治疗与增强认知行为疗法和动态变化机制的试点研究

• 批准号: 10612256
• 负责人: Cheri Alicia Levinson
• 金额: $ 4.56万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10612256
• 关键词: Address; Affective; Anorexia Nervosa; Award; Binge eating disorder; Bulimia; Code; Cognitive; Cognitive Therapy; Data; Doctor of Philosophy; Eating Disorders; Evidence based treatment; Gold; Heterogeneity; Individual; Investigation; K-Series Research Career Programs; Mental disorders; Mentorship; Methods; Minority; Outcome; Participant; Research Personnel; Series; Shame; Shapes; Standardization; Symptoms; Testing; Treatment outcome; United States National Institutes of Health; Variant; Weight; base; career development; cognitive enhancement; mortality; personalized approach; personalized medicine; response; standard care; success

PROJECT SUMMARY/ABSTRACT Despite eating disorders (EDs) carrying one of the highest mortality rates among all psychiatric disorders, there is no evidence-based treatment for anorexia nervosa and only 50% of individuals respond to the gold standard treatment for bulimia nervosa and binge eating disorder (cognitive- behavioral therapy enhanced: CBT-E). These low response rates are likely partially due to the large variations in symptom presentations. One major factor contributing to the high rates of heterogeneity across EDs is the wide variety of cognitive-affective factors, which maintain active illness states. CBT-E is based on the idea that overvaluation of weight and shape is the primary cognitive-affective mechanism responsible for maintaining EDs ‘on average’ (i.e., for most individuals) and is delivered in a standardized format. However, there is a well-documented relationship between “non-traditional” cognitive-affective mechanisms, such as perfectionism, worry, and shame, and EDS. Therefore, a method is needed that can provide a more personalized approach to ED treatment by addressing the high heterogeneity and specifically targeting non-traditional cognitive-affective mechanisms. The specific aims of the proposed project are to: (1) develop a coding system to identify the traditional and non-traditional cognitive-affective targets that are addressed in both a personalized and standardized (CBT-E) treatment, (2) use personalized networks to examine if coded treatment targets correspond with data-identified and manualized (i.e., CBT-E) treatment targets, (3) identify coded profiles of participants with non-traditional cognitive-affective profiles versus ED-traditional cognitive- affective profiles, and (4) test if participants with non-traditional cognitive-affective profiles versus ED-traditional cognitive-affective profiles from idiographic networks differ in treatment outcomes via condition. This project will be an important initial step towards identifying the relations between eating disorders, cognitive-affective factors, and outcomes in eating disorders to use in personalized treatments. Importantly, the career development and mentorship plan outlined in this diversity supplement application will promote Ms. Ortiz’s success as a minority researcher and contribute to the initiative of building a scientific workforce.

项目概要/摘要 尽管饮食失调（ED）是所有精神疾病中死亡率最高的疾病之一 神经性厌食症没有基于证据的治疗方法，只有 50% 的人能治愈 对神经性贪食症和暴食症（认知- 行为疗法增强：CBT-E）。这些低反应率可能部分是由于 症状表现的巨大差异是导致高发病率的一个主要因素。 ED 之间的异质性是认知情感因素的多样性，这些因素维持着活跃的 CBT-E 的基础是高估体重和体形是首要因素。 认知情感机制负责维持“平均”的 ED（即，对于大多数人来说） 个人）并以标准化格式交付，但是有一个详细记录的。 “非传统”认知情感机制之间的关系，例如完美主义， 因此，需要一种可以提供更多信息的方法。 通过解决高度异质性和具体问题来制定个性化的 ED 治疗方法 针对非传统的认知情感机制。 项目目标是：（1）开发一个编码系统来识别传统和非传统 以个性化和标准化（CBT-E）方式解决的认知情感目标 治疗，（2）使用个性化网络检查编码治疗目标是否与 数据识别和手动化（即 CBT-E）治疗目标，（3）识别编码概况 具有非传统认知情感特征的参与者与 ED-传统认知情感特征的参与者 情感概况，以及（4）测试参与者是否具有非传统的认知情感概况 与 ED 相比，来自具体网络的传统认知情感特征在治疗上有所不同 该项目将是确定条件的重要的第一步。 饮食失调、认知情感因素和饮食失调结果之间的关系 重要的是，用于个性化治疗。 此多样性补充申请中概述的内容将促进奥尔蒂斯女士作为少数族裔的成功 研究人员并为建设科学队伍做出贡献。