Child Anxiety Prevention Study Long term Extension

儿童焦虑预防研究长期延伸

• 批准号: 9066817
• 负责人: Golda Susan Ginsburg
• 金额: $ 26.78万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9066817
• 关键词: Address; Adolescence; Adult; Age; Alcohol or Other Drugs use; Anxiety; Anxiety Disorders; Behavior Therapy; Biological Markers; Child; Child Rearing; Communities; Cost Savings; Cost-Benefit Analysis; Costs and Benefits; Data; Databases; Development; Dimensions; Disease; Disease remission; Economic Burden; Effectiveness; Emotions; Evaluation; Family; Fright; Funding; Health; Hydrocortisone; Incidence; Individual; Intervention; Interview; Longitudinal Studies; Measures; Mental Health Services; Mental disorders; Methods; Monitor; National Institute of Mental Health; Onset of illness; Outcome; Parents; Pilot Projects; Population; Prevention; Preventive Intervention; Public Health; Research; Research Domain Criteria; Risk; Salivary; Sampling; Schedule; Severities; Societies; Staging; Symptoms; Target Populations; Time; Translational Research; United States National Institutes of Health; Work; Youth; alpha-amylase; anxiety symptoms; anxiety-related disorders; anxious; base; burden of illness; childhood anxiety; coping; cost; cost effectiveness; depressive symptoms; disability; efficacy trial; executive function; follow-up; health service use; high risk; informant; innovation; intervention effect; intervention program; offspring; prevent; primary outcome; programs; psychiatric symptom; psychologic; response; social; theories; young adult; Address; Adolescence; Adult; Age; Alcohol or Other Drugs use; Anxiety; Anxiety Disorders; Behavior Therapy; Biological Markers; Child; Child Rearing; Communities; Cost Savings; Cost-Benefit Analysis; Costs and Benefits; Data; Databases; Development; Dimensions; Disease; Disease remission; Economic Burden; Effectiveness; Emotions; Evaluation; Family; Fright; Funding; Health; Hydrocortisone; Incidence; Individual; Intervention; Interview; Longitudinal Studies; Measures; Mental Health Services; Mental disorders; Methods; Monitor; National Institute of Mental Health; Onset of illness; Outcome; Parents; Pilot Projects; Population; Prevention; Preventive Intervention; Public Health; Research; Research Domain Criteria; Risk; Salivary; Sampling; Schedule; Severities; Societies; Staging; Symptoms; Target Populations; Time; Translational Research; United States National Institutes of Health; Work; Youth; alpha-amylase; anxiety symptoms; anxiety-related disorders; anxious; base; burden of illness; childhood anxiety; coping; cost; cost effectiveness; depressive symptoms; disability; efficacy trial; executive function; follow-up; health service use; high risk; informant; innovation; intervention effect; intervention program; offspring; prevent; primary outcome; programs; psychiatric symptom; psychologic; response; social; theories; young adult

 DESCRIPTION (provided by applicant): Anxiety disorders in youth are: 1) the most prevalent psychiatric disorders, 2) associated with severe disability, and 3) considered gateway disorders-- as they predict adult psychiatric illnesses. Consequently, these disorders are a public health problem that is costly to afflicted individuals, families, and society. Data on whether these illnesses can be prevented is paramount. Systematic efforts to prevent anxiety disorders in youth appear promising in the short term but data on long-term effectiveness and cost-benefits are lacking. This application proposes an evaluation of the long-term impact and cost-benefits of the Coping and Promoting Strength (CAPS) program (6). CAPS is an intervention aimed at preventing the onset of anxiety disorders in offspring of anxious parents, a population at high risk for developing anxiety and related disorders. Data from the PI's NIMH-funded pilot study and large efficacy trial (K23 MH63427 and R01MH077312) demonstrated promising results at a one year follow-up. This proposed study will continue to evaluate these at risk youth (N = 136) over a four year follow-up period as youth transition into the critical developmental stages of adolescence and young adulthood. This study will be the first long-term follow-up of a preventive intervention for anxiety disorders in high risk offspring, making a major contribution t the field. The study also incorporates several innovative features including 1) a cost-benefit analysis of the intervention, 2) the examination of theory-based mechanisms of intervention effects, and 3) biological markers (e.g., cortisol, alpha amylase, and their coordination) that may help predict illness onset and course. The application was prepared in response to PA- 11-260 and addresses several NIH priorities including: 1) developing and evaluating preventive interventions that reduce the incidence of mental illness, 2) assessing mechanisms of intervention effects across many outcomes (e.g., mental disorders/dimensions, functioning) and 3) incorporating findings from translational science by evaluating salivary biomarkers (i.e., those that reflect HPA axis functioning) to help understand psychiatric illness onset and remission. The study uses rigorous scientific methods including multiple informants and independent evaluators. Findings will inform the field about the intervention impact, mechanisms of intervention effects, costs savings, and predictors (including biomarkers) of illness onset and course. Finally, the study also takes advantage of a rare scientific opportunity by collecting data in this sample that duplicate measures in the PIs follow-up study of clinically anxious youth and healthy controls (R01 MH064089; K24 MH096760) creating a database that will enable comparisons of high risk offspring, clinically anxious, and healthy controls on a number of outcomes including salivary biomarkers and a range of dimensional symptoms outlined the NIMH Research Domain Criteria (e.g., executive functioning, emotion control) that will also be available to the scientific community. Thus, the present study makes efficient use of NIH funds.

 描述（由适用提供）：年轻人的焦虑症是：1）最普遍的精神疾病，2）与严重的残疾相关，3）考虑到门户疾病，因为他们预测了成人精神病。因此，这些疾病是一个公共卫生问题，对受苦的个人，家庭和社会来说是昂贵的。有关是否可以预防这些疾病的数据至关重要。有系统地努力防止在短期内促进青年的焦虑症，但缺乏有关长期有效性和成本效益的数据。该申请建议评估应对和促进力量（CAPS）计划的长期影响和成本效益（6）。 CAPS是一种干预措施，旨在防止焦虑父母后代的焦虑症发作，这是患动画和相关疾病的高风险的人群。 PI NIMH资助的试点研究和大型效率试验（K23 MH63427和R01MH077312）的数据显示了一年的随访结果。这项拟议的研究将继续在四年的随访期内继续评估这些风险青年（n = 136），因为青少年和成年年轻人的关键发展阶段过渡。这项研究将是对高风险后代的焦虑症进行预防性干预的长期随访，从而做出了重大贡献。该研究还纳入了几种创新特征，包括1）对干预的成本效益分析，2）研究基于理论的干预效果机制，以及3）生物学标记（例如，皮质醇，α淀粉酶及其协调），这些标志物可能会检查，这些标志物可能 有助于预测疾病的发作和过程。该应用是针对PA-11-260的响应准备的，并解决了几个NIH的优先级，包括：1）开发和评估降低精神疾病强度的预防干预措施，2）评估在许多结果（例如，精神障碍/维度，功能，功能）和3）通过评估科学的发现（例如，这些结果）的研究机制（例如，精神疾病障碍/维度）（例如，精神障碍/维度）进行了评估。 这反映了HPA轴功能），以帮助了解精神病的发作和缓解。该研究使用严格的科学方法，包括多个线人和独立评估者。调查结果将为领域提供干预影响，干预效果的机制，节省成本和预测因素（包括生物标志物）的疾病发作和过程。最后，该研究还通过收集数据来利用罕见的科学机会 在此样本中，在PIS临床焦虑的青年和健康对照组（R01 MH064089; K24 MH096760）的PIS后续研究中重复措施的样本中（例如，执行功能，情绪控制）也将向科学界使用。这是本研究有效利用NIH资金。