Genetic Analyses For Epidemiologic Studies Of Respiratory Disease

呼吸道疾病流行病学研究的基因分析

• 批准号: 9352083
• 负责人: Stephanie London
• 金额: $ 44.3万
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9352083
• 关键词: Adult; Animals; Asthma; Biology; Childhood Asthma; Epidemiologic Studies; Epidemiology; Epigenetic Process; Genetic; Hypersensitivity; Knock-out; Knockout Mice; Laboratories; London; Lung diseases; Role; Work; airway obstruction; follow-up; gene environment interaction; genetic analysis; genetic epidemiology; genome wide association study; genome-wide; mouse model; pulmonary function; research study; respiratory

This project describes the role of the lab of Stephanie London in the Laboratory of Respiratory Biology in support of her epidemiologic studies. The laboratory is engaged in genetic and epigenetic analyses to support Dr. Londons epidemiologic projects. In the past year, we have focused on genome wide approaches. The lab supports follow-up of findings from our genome wide association studies of childhood asthma as well as adult pulmonary function. In the past year this project has been devoted to follow-up of genome wide association study findings in relation to pulmonary function that we have had in our other projects. We have been using murine models for this follow. In the past year we have performed work on htr4 knock out mouse models. We have developed Lrp1 conditional knock out mouse models and have started experiments with these. We will soon have Adam19 conditional knock out experimental animals.

该项目描述了斯蒂芬妮·伦敦实验室在呼吸生物学实验室中的作用，以支持其流行病学研究。该实验室进行了遗传和表观遗传分析，以支持隆登顿博士的流行病学项目。在过去的一年中，我们专注于基因组广泛的方法。该实验室支持对我们基因组广泛的儿童哮喘和成人肺功能研究的发现的随访。在过去的一年中，该项目致力于对基因组广泛的关联研究结果进行跟进，以与我们在其他项目中所拥有的肺功能有关。 为此，我们一直在使用鼠模型。在过去的一年中，我们已经在HTR4敲除鼠标模型上进行了工作。我们已经开发了LRP1条件敲除小鼠模型，并开始对其进行实验。我们很快就会有ADAM19有条件地淘汰实验动物。