DORMIR: Determinants, Outcomes, Responses and Markers of Insufficient sleep in Rural-Urban settings

DORMIR：城乡睡眠不足的决定因素、结果、反应和标志

基本信息

批准号：
10598875
负责人：
Azizi Seixas
金额：
$ 81.16万
依托单位：
UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-05 至 2025-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10598875
关键词：
Address Adverse effects Affect Age Air Americas Bayesian learning Behavioral Behavioral Genetics Biological Biometry Birth Place Blood Pressure Cardiovascular Diseases Cause of Death Cessation of life Circadian desynchrony Collection Communities Data Devices Diabetes Mellitus Diet Diet and Nutrition Discrimination Disease Marker Disease Outcome Dyslipidemias Emotional Enrollment Environment Environmental Risk Factor Epidemiology Ethnic group Exhibits Foundations Funding Genetic Genetic Markers Genotype Geographic Information Systems Glucose Glycosylated hemoglobin A Health High Prevalence Home Hour Household Hypertension Individual Inflammation Inflammatory Insulin Resistance Interleukin-10 Interleukin-6 Intervention Latino Lead Length of Stay Level of Evidence Life Life Style Light Link Lipids Machine Learning Methodology Modeling Morbidity - disease rate Nature Neighborhoods New York Noise Not Hispanic or Latino Obesity Outcome Overweight Physical activity Policies Population Study Predictive Factor Process Psychosocial Factor Public Health Reduce health disparities Research Research Personnel Risk Risk Factors Risk Marker Rural Rural Community Sampling Science Seminal Sleep Sleep Apnea Syndromes Sleep Deprivation Sleep Disorders Sleeplessness Socioeconomic Status Stress System TNF gene Temperature Time United States National Institutes of Health Urban Community actigraphy arterial stiffness base built environment burden of illness cardiovascular disorder risk circadian clinically actionable density design disease disparity diverse data ethnic minority ethnic minority population experience fasting plasma glucose good diet health data health disparity improved inflammatory marker innovation instrumentation mHealth models and simulation modifiable risk mortality multidisciplinary novel population based psychosocial racial and ethnic recruit response biomarker rural area rural setting sex sleep health smoking cessation social success tool urban area urban disparity urban setting

项目摘要

Project Summary The widening gap in all-cause and CVD-mortality and morbidity rates in rural and urban America is at an all- time high. Latino/as, the largest minority ethnic group in the U.S., appear to be most affected by rural-urban divide in CVD outcomes, as they are disproportionately burdened by CVD risk (overweight/obesity, hypertension, dyslipidemia, diabetes) and CVD mortality (20%, 2nd leading cause of death among Latino/as) relative to other racial/ethnic groups. Unlike other groups where individuals in rural and urban areas have differing CVD risk, rural and urban Latino/as have similarly high rates of CVD risk. Although, healthy diets/ nutrition, smoking cessation, and regular physical activity are linked to CVD risk, they have not been very effective in reducing the CVD burden among racial/ethnic groups, specifically among Latino/as. Several studies indicate that insufficient sleep (<7hrs./day) explains a significant amount of the CVD burden among Latino/as. Preliminary evidence indicates that insufficient sleep may contribute to the observed CVD burden among Latino/as, as Latino/as have greater odds of experiencing insufficient sleep compared with non-Hispanic whites. Evidence also shows that insufficient sleep, which is associated with potentially life-threatening CVD, is a key modifiable risk factor with great potential to reduce health disparities. However, it is unclear what factors contribute to insufficient sleep (IS) disparities and IS-related CVD burden among rural and urban Latino/as. To address these gaps, we will enroll 525 Latino/as in rural and urban communities to participate in home-based studies using novel mHealth devices. The multidisciplinary team will: 1) identify behavioral, genetic, psychosocial, and environmental factors that are associated with insufficient sleep and IS-related CVD and 2) assess effects of insufficient sleep on CVD risk markers (obesity, blood pressure, lipid profile, and fasting plasma glucose/ HbA1C) and inflammatory risk markers (IL-6, IL-10, and TNF-α). This study will provide multi-level evidence supporting epidemiological findings of greater rates of insufficient sleep among Latino/as, which may explain their disproportionate burden of CVD risk. It will also assess whether and why rural and urban differences in IS exist among Latino/as and how that may lead to IS-related CVD outcomes. These data will provide: 1) the foundation for interventions to mitigate adverse effects of insufficient sleep on CVD health outcomes, 2) evidence to delineate factors underlying insufficient sleep and CVD burden among Latino/as in rural and urban settings, and 3) a possible explanation of behavioral, genetic, environmental and psychosocial determinants of insufficient sleep and related CVD risk factors in rural and urban Latino/as. Findings can lead to actionable clinical, lifestyle, and policy interventions to improve Latino health.

项目概要美国农村和城市的全因死亡率和心血管疾病死亡率和发病率差距不断扩大拉丁裔/黑人是美国最大的少数族裔群体，似乎受城乡影响最大。 CVD 结果存在差异，因为 CVD 风险（超重/肥胖、高血压、血脂异常、糖尿病）和心血管疾病死亡率（20%，拉丁裔/拉丁裔第二大死亡原因）与其他种族/族裔群体不同，农村和城市地区的个人具有不同的特征。不同的 CVD 风险，农村和城市拉丁裔/亚裔的 CVD 风险率相似，但健康饮食/。营养、戒烟和定期体育活动与 CVD 风险有关，但目前还没有很明确的研究多项研究可有效减少种族/族裔群体，特别是拉丁裔/as 的 CVD 负担。表明睡眠不足（每天少于 7 小时）是拉丁裔/黑人 CVD 负担的重要原因。初步证据表明，睡眠不足可能会导致观察到的 CVD 负担与非西班牙裔人相比，拉丁裔/西班牙人睡眠不足的可能性更大证据还表明，睡眠不足与可能危及生命的心血管疾病有关。是一个关键的可改变的风险因素，具有减少健康差异的巨大潜力，但目前尚不清楚是什么。导致城乡睡眠不足 (IS) 差异和 IS 相关心血管疾病负担的因素为了解决这些差距，我们将在农村和城市社区招募 525 名拉丁裔/as 参与。使用新型移动医疗设备进行家庭研究。多学科团队将：1）识别行为、与睡眠不足和 IS 相关 CVD 相关的遗传、社会心理和环境因素 2) 评估睡眠不足对 CVD 风险标志物（肥胖、血压、血脂和本研究将检测空腹血糖/ HbA1C）和炎症风险标志物（IL-6、IL-10 和 TNF-α）。提供多层次证据支持流行病学发现，即睡眠不足率较高拉丁裔/黑人，这可以解释他们的 CVD 风险负担过重。它还将评估是否以及原因。拉丁裔/黑人在 IS 方面存在农村和城市差异，以及这如何导致与 IS 相关的 CVD 结果。这些数据将提供：1）为减轻睡眠不足对身体的不利影响的干预措施奠定基础。 CVD 健康结果，2) 描述睡眠不足和 CVD 负担背后因素的证据农村和城市环境中的拉丁裔/拉丁裔，以及 3) 对行为、遗传、环境和农村和城市拉丁美洲人睡眠不足的心理社会决定因素以及相关的心血管疾病危险因素。研究结果可以带来可行的临床、生活方式和政策干预措施，以改善拉丁裔的健康。