Neurobiology of pain experiences in youth in the ABCD study

ABCD 研究中青少年疼痛经历的神经生物学

基本信息

批准号：
10597790
负责人：
Anna Camille Wilson
金额：
$ 42.35万
依托单位：
OREGON HEALTH & SCIENCE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-23 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10597790
关键词：
12 year old Address Adolescence Adolescent Adult Age Amygdaloid structure Anterior Anxiety Base of the Brain Brain Brain region Characteristics Childhood Complex Data Depressed mood Development Diffusion Magnetic Resonance Imaging Eligibility Determination Emotional Female Functional Magnetic Resonance Imaging Goals Hippocampus (Brain)Incidence Individual Insula of Reil Intervention Lateral Location Magnetic Resonance Imaging Maintenance Mediating Mental Depression Mental Health Modeling Neurobiology Pain Pain Measurement Pain intensity Parietal Lobe Patient Self-Report Pattern Persistent pain Phenotype Physical activity Population Predictive Factor Prospective Studies Public Health Reporting Research Rest Rewards Risk Risk Assessment Risk Factors Sampling Short-Term Memory Sleep disturbances Structure Substance abuse problem Syndrome Temporal Lobe Thick Time United States National Institutes of Health Ventral Striatum Youth affective disturbance biopsychosocial biopsychosocial factor chronic pain cohort comorbid depression comorbidity cost critical period depressive symptoms emotional functioning emotional stimulus executive function experience gray matter imaging modality mind control multilevel analysis neural circuit neuroimaging novel therapeutic intervention pain symptom physical conditioning prevent preventive intervention programs prospective protective factors public health relevance relating to nervous system response reward processing sex societal costs

项目摘要

Neurobiology of pain experiences in youth in the ABCD study Project Summary Chronic pain is a massive public health problem, with wide impact and profound detrimental effects on mental and physical health of those afflicted, resulting in large societal cost. Of chronic pain syndromes, many are more prevalent in females, and incidence increases dramatically during adolescence. Pediatric chronic pain is costly in its own right, and unfortunately individuals with chronic pain in adolescence are likely to have pain persist into adulthood, and experience high rates of comorbid depression and substance abuse. There are known risk factors for chronic pain, including female sex, low levels of physical activity, depressed mood, and sleep disturbance, but mechanisms underlying pain persistence are not well understood, particularly from a neurobiological perspective. Additionally, in pediatric populations there is minimal research on neurobiological correlates of pain in sufficiently large samples, and limited prospective research on pain trajectories incorporating neurobiological data. In this study, we will prospectively examine neurobiological and biopsychosocial features associated with pain during adolescence, a critical period for development of emotional and regulatory functioning, to predict pain maintenance and associated impacts over time. To do this, we will utilize data from an estimated n=3773 11-12 year olds (49% female) participating in the ABCD Study who report experiencing pain in the past month, as well as an equal-sized comparison sample, matched on age and demographic variables, who report experiencing no pain in the past month. We will utilize resting state, functional, and structural neuroimaging, and comprehensive phenotypic assessment of risk factors at baseline to characterize the neurobiological correlates of pain experiences in this large sample. We will then examine pain trajectories over time (maintenance, increases, or decreases in reports of pain intensity, pain locations, and pain-related activity limitations), and utilize hypothesis-driven longitudinal modeling approaches to identify brain-based and biopsychosocial risk factors predicting sustained and escalating pain. Results will inform our fundamental understanding of neurobiological and related biopsychosocial risk for the development of chronic pain during a key developmental period, and will inform development of screening protocols and targeted preventive interventions.

ABCD 研究中青少年疼痛经历的神经生物学项目概要慢性疼痛是一个严重的公共卫生问题，对精神产生广泛的影响和深远的有害影响以及患者的身体健康，造成巨大的社会成本。在慢性疼痛综合征中，许多是多见于女性，青春期发病率急剧上升。小儿慢性疼痛是其本身的成本就很高，不幸的是，青春期患有慢性疼痛的人很可能会出现疼痛持续到成年，并且患有抑郁症和药物滥用的共病率很高。有慢性疼痛的已知危险因素，包括女性、体力活动水平低、情绪低落和睡眠障碍，但持续疼痛的机制尚不清楚，特别是来自神经生物学的观点。此外，在儿科人群中，关于神经生物学的研究很少足够大的样本中疼痛的相关性，以及对疼痛轨迹的前瞻性研究有限结合神经生物学数据。在这项研究中，我们将前瞻性地研究神经生物学和与青春期疼痛相关的生物心理社会特征，这是发展的关键时期情绪和调节功能，以预测随着时间的推移疼痛的维持和相关影响。要做的事为此，我们将利用参与 ABCD 的估计 n=3773 名 11-12 岁儿童（49% 女性）的数据研究报告在过去一个月中经历过疼痛，以及同等大小的比较样本，匹配根据年龄和人口统计变量，他们报告在过去一个月没有感到疼痛。我们将利用休息时间状态、功能和结构神经影像，以及危险因素的综合表型评估基线来描述这个大样本中疼痛经历的神经生物学相关性。我们随后将检查一段时间内的疼痛轨迹（疼痛强度、疼痛报告的维持、增加或减少）位置和与疼痛相关的活动限制），并利用假设驱动的纵向建模方法识别基于大脑和生物心理社会的风险因素，预测持续和不断升级的疼痛。结果将告知我们对发育的神经生物学和相关生物心理社会风险的基本理解关键发育时期的慢性疼痛，并将为筛查方案的制定和有针对性的预防干预措施。