Increasing physical activity among breast cancer survivors: Use of the ORBIT Model to refine and test a novel approach to exercise promotion based on affect-regulation

增加乳腺癌幸存者的体力活动：使用 ORBIT 模型完善和测试基于情感调节的运动促进新方法

• 批准号: 10593920
• 负责人: Courtney Joyce Stevens
• 金额: $ 17.58万
• 依托单位: DARTMOUTH-HITCHCOCK CLINIC
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10593920
• 关键词: Accelerometer; Address; Adherence; Adverse effects; Affect; Affective; Aftercare; American; Arousal; Award; Behavior; Behavior Therapy; Behavioral; Breast Cancer Risk Factor; Breast Cancer survivor; Breast Cancer survivorship; Cancer Survivor; Cancer Survivorship; Clinical; Clinical Trials Design; Consultations; Data; Data Analyses; Data Collection; Development; Diagnosis; Doctor of Philosophy; Ecological momentary assessment; Exercise; Fatigue; Feeling; General Population; Goals; Guidelines; Health Benefit; Health behavior; Individual; Intervention; Intervention Trial; Investigation; K-Series Research Career Programs; Knowledge; Light; Longitudinal Studies; Malignant Neoplasms; Measures; Medical center; Mentors; Methods; Modeling; Modification; Obesity; Oncology; Outcome; Participant; Persons; Phase; Phase Ib Trial; Physical Function; Physical activity; Positioning Attribute; Protocols documentation; Psychologist; Public Health; Randomized; Recommendation; Recurrent Malignant Neoplasm; Regulation; Research; Research Personnel; Risk Factors; Sampling; Science; Scientist; Sports Medicine; Strenuous Exercise; Structure; Surveys; Survivors; Testing; Time; Training; Treatment-Related Cancer; Variant; Work; adherence rate; arm; cancer diagnosis; cancer recurrence; career; career development; college; design; exercise prescription; exercise regimen; follow-up; health related quality of life; hedonic; improved; innovation; malignant breast neoplasm; method development; modifiable risk; mortality; motivated behavior; novel strategies; participant interview; patient oriented; physical conditioning; physical inactivity; pleasure; post intervention; preference; randomized, clinical trials; response; satisfaction; skills; standard of care; therapy development

PROJECT SUMMARY/ABSTRACT The goal of this K08 Mentored Clinical Scientist Research Career Development Award is to prepare the candidate for an independent research career Breast cancer survivors who exercise regularly in behavioral oncology and health behavior intervention science. post-cancer diagnosis are less likely to die from cancer and even modest increases in physical activity (≥ related mortality. However, longitudinal studies show significant declines in exercise engagement during the 12- 15 minutes/week) yield clinically meaningful reductions in breast cancer- months post-diagnosis, with most breast cancer survivors never fully returning to pre-diagnosis activity levels. The candidate proposes an innovative approach, based on affect-regulation, to addressing physical inactivity as a public health risk factor negatively impacting breast cancer survivorship. The training and mentoring plan is designed to provide knowledge and skills in (1) early-phase intervention development, (2) intensive longitudinal data collection and analysis methods, (3) randomized clinical trial design, and (4) professional development. The proposed research will refine an affect-regulated exercise prescription strategy (Affect-Rx) for use with physically inactive breast cancer survivors (Aim 1), test for proof-of-concept the effect of Affect-Rx on clinically meaningful moderate-vigorous physical activity participation post-intervention, operationalized as ≥ 90 mins/week (Aim 2), and quantify the strength of within-person associations between affective factors and total physical activity (Aim 3). The candidate will use the milestones for early-phase intervention development established by the Obesity- Related Behavioral Intervention Trials (ORBIT) two studies. In both studies, participants’ daily Model to guide the methods and outcomes to be tested across affective feeling states and physical activity will be measured using ecological momentary assessment (EMA) and accelerometry at baseline and 2-, 6- and 12-weeks follow- up. The Affect-Rx strategy will be refined for acceptability in Study 1 (N = 20) and tested (with refinements) in Study 2 (N = 60). In consultation with her team of mentors and scientific advisors, the candidate will use the training, the results of the research, and the ORBIT intervention development framework to systematically guide the next steps in this affect-based physical activity promotion line of work and submit her first R01 proposal.

项目概要/摘要 K08 指导临床科学家研究职业发展奖的目标是为 独立研究职业的候选人 经常锻炼的乳腺癌幸存者 行为肿瘤学和健康行为干预科学。 癌症后诊断的人死于癌症的可能性较小，甚至 体力活动适度增加（≥ 然而，纵向研究表明，12-12 年间运动参与度显着下降。 每周 15 分钟）产生具有临床意义的乳腺癌减少 - 诊断后几个月，大多数乳腺癌幸存者从未完全恢复到诊断前的活动水平。 候选人提出了一种基于情感调节的创新方法，以解决身体不活动问题 对乳腺癌生存产生负面影响的公共卫生风险因素是培训和指导计划。 旨在提供以下方面的知识和技能：（1）早期干预开发，（2）强化纵向 数据收集和分析方法，（3）随机临床试验设计，以及（4）专业发展。 拟议的研究将完善一种情绪调节运动处方策略（Affect-Rx），用于身体健康 不活跃的乳腺癌幸存者（目标 1），测试 Affect-Rx 对临床意义的影响的概念验证 干预后中等强度的体力活动参与，可操作为 ≥ 90 分钟/周 （目标 2）， 并量化情感因素和总体身体活动之间的人内关联强度（目标 3).候选人将使用肥胖协会制定的早期干预发展里程碑- 相关行为干预试验 (ORBIT) 在两项研究中，参与者的日常情况。 指导测试方法和结果的模型 将测量情感感觉状态和身体活动 在基线和 2、6 和 12 周后使用生态瞬时评估 (EMA) 和加速测量法 Affect-Rx 策略将在研究 1 (N = 20) 中进行改进以提高可接受性，并在研究 1 (N = 20) 中进行测试（经过改进）。 研究 2（N = 60）。在与导师和科学顾问团队协商后，候选人将使用 培训、研究结果以及 ORBIT 干预开发框架系统地指导 下一步是基于情感的身体活动促进工作，并提交她的第一个 R01 提案。