Investigation of a novel prelimbic cortical peptidergic population in binge drinking behavior

暴饮行为中新型前边缘皮质肽能群体的研究

基本信息

批准号：
10263516
负责人：
Nicole Ashley Crowley
金额：
$ 8.03万
依托单位：
PENNSYLVANIA STATE UNIVERSITY, THE
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-05-01 至 2023-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10263516
关键词：
Acute Address Agonist Alcohol consumption Alcohols Bathing Behavior Brain Brain Diseases Cessation of life Chronic Clinical Criminal Justice Data Disease Electrophysiology (science)Ethanol Exhibits Female Foundations Goals Health Healthcare Internal Ribosome Entry Site Interneurons Investigation Light Link Major Depressive Disorder Modeling Mus Neurobiology Neurons Parvalbumins Pattern Peptide Signal Sequences Peptides Pharmacology Play Population Prefrontal Cortex Prosencephalon Protocols documentation Public Health Relapse Role Signal Transduction Social Work Somatostatin Somatostatin Receptor Synapses Synaptic Transmission Translating Virus Work alcohol abuse therapy alcohol exposure alcohol misuse alcohol use disorder binge drinking comorbidity cost depressive symptoms designer receptors exclusively activated by designer drugs drinking drinking behavior experimental study gamma-Aminobutyric Acid hippocampal pyramidal neuron insight interest male mouse model neuropsychiatric disorder novel optogenetics reduced alcohol use relating to nervous system research study resilience sex substance misuse therapeutic target

项目摘要

Project Summary Alcohol Use Disorder (AUD) is a chronic brain disease with major health and societal concerns resulting in more deaths than any other type substance misuse. Of all the forms of alcohol misuse, binge drinking is the most common, costly, and deadly pattern of excessive alcohol use. Addressing this major public health problem requires a better understanding of the underlying neurobiology of binge drinking. One region of particular interest for binge-drinking is the prelimbic cortex (PL). We have previously shown that excitatory and inhibitory signaling in the PL is altered following a variety of models of ethanol exposure. In addition, our preliminary data indicates that somatostatin neurons in the PL are involved in alcohol binge drinking in both sexes. This is particularly novel as it represents a promising neuronal population capable of reducing binge drinking behavior. Our project will (1) investigate how PL somatostatin neurons interact with other neurons (synaptic connectivity and signaling), and (2) what role they play in binge drinking (chemogenetic activation and inhibition). Taken together, these experiments will assess the hypothesis that somatostatin neurons in the PL are a promising therapeutic target for alcohol use disorder, and binge drinking in particular.

项目概要酒精使用障碍 (AUD) 是一种慢性脑部疾病，会导致严重的健康和社会问题比任何其他类型的物质滥用造成的死亡都要多。在所有滥用酒精的形式中，酗酒是最严重的最常见、代价高昂且致命的过量饮酒模式。解决这一重大公共卫生问题需要更好地了解酗酒的潜在神经生物学。某一特定地区对酗酒的兴趣是前边缘皮层（PL）。我们之前已经表明，兴奋性和抑制性 PL 中的信号传导在各种乙醇暴露模型后发生改变。另外，我们的初步数据表明 PL 中的生长抑素神经元与男女酗酒有关。这是特别新颖，因为它代表了一种有前途的神经元群体，能够减少酗酒行为。我们的项目将 (1) 研究 PL 生长抑素神经元如何与其他神经元相互作用（突触连接和信号传导），以及（2）它们在酗酒中发挥什么作用（化学遗传学激活和抑制）。采取总之，这些实验将评估以下假设：PL 中的生长抑素神经元是一种有前途的神经元。酒精使用障碍，特别是酗酒的治疗目标。