Neurocognitive Markers of Fetal Alchol SPectrum Disorders

胎儿酒精谱系疾病的神经认知标志物

• 批准号: 9069402
• 负责人: PIYADASA W KODITUWAKKU
• 金额: $ 17.84万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9069402
• 关键词: 12 year old; Affect; Age; Alcohol-Related Neurodevelopmental Disorder; Attention; Attention deficit hyperactivity disorder; Behavioral; Brain; Child; Clinical; Cognitive; Consensus; Control Groups; Data; Diagnosis; Diffusion Magnetic Resonance Imaging; Electroencephalography; Ethanol; Evaluation; Fetal Alcohol Exposure; Fetal Alcohol Spectrum Disorder; Fetal Diseases; Goals; Healthcare; Impairment; Intervention; Investigation; Lead; Magnetic Resonance Imaging; Measures; Methodology; Methods; Neurocognitive; Neurons; Neuropsychological Tests; Parietal; Parietal Lobe; Participant; Performance; Procedures; Psychological Tests; Reporting; Research; Speed; Symptoms; Visual; base; behavior measurement; behavior test; clinically significant; cognitive testing; executive function; fetal; indexing; information processing; innovation; millisecond; neuroimaging; novel; novel strategies; processing speed; relating to nervous system; response; sustained attention; temporal measurement; theories

A 2011 consensus statement issued by the Interagency Coordinating Committee on Fetal Alcohol Spectrum Disorders recommended rigorous scientific investigation aimed at refining our understanding of cognitive and behavioral profiles of alcohol-related neurodevelopmental disorder (ARND). Therefore, the broad, long-term goal of this research is to develop and validate clinically practical procedures to identify children with ARND. The main objective of the current project is to evaluate the sensitivity of functional (MEG/EEG) and structural (MRI/DTI) neuroimaging methods and cognitive-behavioral tests in differentiating children with fetal alcohol spectrum disorders (FASD; both FAS and ARND) from children with attention deficit hyperactivity disorder (ADHD) and typically developing controls (TDC). The central hypothesis is that the speed of information processing at a neuronal level differentiates children with FASD from other clinical groups with similar behavioral profiles. Preliminary data are in keeping with this processing speed hypothesis. MEG and EEG will be simultaneously recorded while participants, 8 to 12 years of age, perform two tasks: visual prosaccades and the Sustained Attention to Response Task (SART). MRI and diffusion tensor imaging will also be performed. The rationale tor concurrent MEG and EEG is that MEG can inform the interpretation of EEG data. Furthermore, the high temporal resolution (milliseconds) of MEG/EEG allows one to directly assess speed of information processing. A behavioral test battery comprised of measures shown to be sensitive to the effects of prenatal alcohol exposure will also be administered. Using this methodology, three specific aims will be pursued: 1. Determine the functional (MEG/EEG) and structural (MRI/DTI) underpinnings of visual prosaccades and its relation to cognitive-behavioral measures in children with FASD, ADHD, and TDC. 2. Identify the functional and structural networks of the SART and their association with cognitive-behavioral measures in children with FASD, ADHD, and TDC. 3. Identify a set of clinically useful (EEG and cognitive-behavioral) measures that optimally differentiate between groups. This theory-driven approach is innovative by identifying 'neuro-cognitive markers' of prenatal alcohol exposure. It further proposes a novel approach to concurrently record MEG/EEG during two tasks that can be used across a broad age range and different cultures. It is expected that the proposed research will lead to a unique set of neurocognitive markers that can be used clinically to identify children with FASD, particularly those with ARND. Use of EEG and neuro-cognitive indices is clinically significant because these procedures are widely available.

2011年由胎儿酒精谱系互联地协调委员会发表的共识声明建议进行严格的科学研究，旨在完善我们对酒精相关神经发育障碍（ARND）认知和行为概况的理解。因此，这项研究的广泛长期目标是制定和验证临床实用程序以识别患有ARND的儿童。当前项目的主要目的是评估功能（MEG/EEG）和结构性（MRI/DTI）神经成像方法的敏感性以及在胎儿酒精谱障碍儿童（FASD； FAS和ARND）的分化儿童中的认知行为测试（FAS; FAS; FAS; FAS; FAS; FAS; FAS; FAS; FAS; FAS coction Deficitive deficitive deficitive deficitive teficitive）均不受欢迎（ADHD）（典型地）（典型地）（典型地）。中心假设是，神经元水平的信息处理速度将FASD儿童与其他行为谱相似的临床组区分开来。初步数据与此处理速度假设一致。梅格和脑电图将同时记录，而8至12岁的参与者执行了两项任务：视觉阶段和对响应任务的持续关注（SART）。还将执行MRI和扩散张量成像。 MEG和EEG的基本原理是MEG可以为脑电图数据的解释提供信息。此外，MEG/EEG的高时间分辨率（毫秒）允许人们直接评估信息处理速度。还将管理一种行为测试电池，该电池由显示对产前酒精暴露的影响敏感的措施组成。使用这种方法，将追求三个具体目标：1。确定视觉前扫描的功能（MEG/EEG）和结构（MRI/DTI）基础，以及其与FASD，ADHD和TDC儿童的认知行为措施的关系。 2。确定SART的功能和结构网络及其与FASD，ADHD和TDC儿童的认知行为措施的关联。 3.确定一组临床上有用的（脑电图和认知行为）的措施，可在组之间进行最佳区分。通过鉴定产前酒精暴露的“神经认知标记”，这种理论驱动的方法具有创新性。它进一步提出了一种新颖的方法，以同时记录MEG/EEG的两项任务，这些任务可在广泛的年龄范围内和不同的文化中使用。预计拟议的研究将导致一组独特的神经认知标记，可在临床上使用来鉴定患有FASD的儿童，尤其是患有ARND的儿童。脑电图和神经认知指数的使用具有临床意义，因为这些程序已广泛可用。