Tulane COBRE for Clinical and Translational Research in Cardiometabolic Diseases

杜兰大学 COBRE 用于心脏代谢疾病的临床和转化研究

• 批准号: 8813111
• 负责人: Jiang He
• 金额: $ 255.75万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-03-10 至 2021-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8813111
• 关键词: Adult; Advisory Committees; African American; Albuminuria; Angiotensinogen; Area; Asians; Award; Biological Markers; Biostatistics Core; Blood Pressure; Cardiovascular Diseases; Cardiovascular system; Centers of Research Excellence; Childhood; Chronic Kidney Failure; Clinical; Clinical Investigator; Clinical Research; Collaborations; Communities; Community Outreach; Core Facility; Dietary Sodium; Disease; Etiology; Evaluation; Event; Evidence based intervention; Excretory function; Faculty; Funding; Generations; Genes; Genomic Segment; Glycosylated Hemoglobin; Goals; Grant; Health; Health Policy; Heart; Inflammatory; Insulin; Insulin Resistance; Interdisciplinary Study; Knowledge; Laboratories; Longitudinal Studies; Louisiana; Low Birth Weight Infant; Mass Fragmentography; Measures; Mediating; Mentors; Metabolic; Methods; Morbidity - disease rate; N.I.H. Research Support; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Participant; Patient Care; Patients; Peer Review Grants; Play; Population; Prevention; Public Health; Public Health Schools; Race; Randomized Controlled Trials; Records; Recruitment Activity; Research; Research Infrastructure; Research Methodology; Research Personnel; Research Project Grants; Research Support; Resources; Risk; Risk Factors; Role; Science; Scientist; Series; Technology; Testing; Training; Translational Research; Translations; Tropical Medicine; United States National Institutes of Health; Universities; Ursidae Family; Writing; acute coronary syndrome; base; cardiovascular disorder risk; career; career development; clinical application; community based participatory research; deep sequencing; disability; disorder prevention; experience; genetic variant; genome wide association study; health disparity; implementation research; improved; interest; knowledge translation; liquid chromatography mass spectrometry; medical schools; meetings; metabolomics; mortality; multidisciplinary; next generation sequencing; novel; outreach program; programs; public health relevance; research facility; salicylsalicylic acid; senior faculty; success; urinary

 DESCRIPTION (provided by applicant): The overall objective of this COBRE application is to increase the quality and quantity of clinical, translational and implementation research in cardiometabolic diseases at Tulane University. This objective will be achieved by establishing a Center of Excellence for Clinical, Translational and Implementation Research in Cardiometabolic Diseases at Tulane University; developing and nurturing successful competitive independent investigators in clinical, translational and implementation research; motivating and facilitating multidisciplinary and interdisciplinary interaction and collaboration i the area of cardiometabolic disease research; and building and expanding the clinical and community-based research infrastructure at Tulane University and in Louisiana. We will recruit and mentor 7-10 junior faculty investigators and enhance their ability to successfully and independently compete for external peer-reviewed grants from the NIH and other national research agencies. We will provide scientific and administrative support to the junior faculty investigators through strong research core facilities so that they can accomplish the aims of the proposed five research projects. These research projects are focused on the prevention and treatment of cardiovascular diseases and metabolic risk factors through the generation and translation of knowledge from laboratory, clinical, and population studies to real- world clinical and public health settings. An internal advisory committee composed of mentors and core directors for this COBRE application are all strongly committed to this program and have outstanding track records in successfully conducting NIH-supported research and mentoring junior faculty. In addition, a prominent board of external advisors with exceptional research careers and experience in developing junior scientists will be selected to provide both guidance and evaluation of the progress of junior faculty investigators and the COBRE program as a whole. Mentors will use defined and proven methods to enhance the development and career success of the junior faculty. A series of program meetings, research seminars, and didactic grant-writing sessions will be provided to the junior faculty investigators to enhance their career development. Clinical research facilities and community outreach programs will be developed and expanded. The ultimate goal of this COBRE program is to establish an internationally recognized multidisciplinary research program in the etiology, prevention, and treatment of cardiometabolic diseases in Louisiana. Tulane University and its School of Public Health and Tropical Medicine and School of Medicine have all committed to the success of the proposed COBRE program. The proposed COBRE program is unique and novel because it emphasizes developing and nurturing clinical investigators and promoting clinical, population, and community- based research, which has a direct impact on patient care and disease prevention. This proposed COBRE application, if funded, will contribute to reducing the burden of cardiovascular diseases and metabolic risk factors, eliminating health disparities, and improving health both in Louisiana and the general US population.

 描述（由应用程序提供）：该毛线应用的总体目标是提高杜兰大学心脏代谢疾病中临床，转化和实施研究的质量和数量。这一目标将通过在杜兰大学建立临床，转化和实施研究中的卓越临床，转化和实施研究中心来实现这一目标；在临床，转化和实施研究方面开发和培养成功的独立研究人员；激励和支持跨学科和跨学科的互动和协作I心脏代谢疾病研究领域；以及在杜兰大学和路易斯安那州建立和扩展基于临床和社区的研究基础设施。我们将招募和指导7-10名初级教师调查员，并增强其成功和独立竞争来自NIH和其他国家研究机构的外部同行评审的赠款的能力。我们将通过强大的研究核心设施向初级教师调查员提供科学和行政支持，以便他们可以实现拟议的五个研究项目的目标。这些研究项目的重点是预防和治疗心血管疾病和代谢危险因素，通过从实验室，临床和人群研究到现实世界中的临床和公共卫生环境的知识来翻译和翻译。由这项毛绒申请的导师和核心主管组成的内部咨询委员会都强烈致力于该计划，并在成功进行NIH支持的研究和心理初级教职员工方面拥有出色的记录。此外，将选择具有卓越的研究职业和开发初级科学家的经验的著名外部顾问委员会，以提供对初级教师研究人员和整个Cobre计划进步的指导和评估。导师将使用定义并证明方法来增强初级教师的发展和职业成功。将向初级教师调查人员提供一系列课程会议，研究半读和教学授予写作会议，以增强他们的职业生涯 发展。临床研究设施和社区外展计划将得到发展和扩展。该毛茸茸计划的最终目标是在路易斯安那州的病因，预防和治疗方面，预防和治疗方面建立一项国际认可的多学科研究计划。杜兰大学及其公共卫生与热带医学学院以及医学院都致力于拟议的鞋底计划的成功。拟议的鞋底计划是独特而新颖的，因为它强调开发和培育临床研究人员并促进临床，人群和基于社区的研究，这直接影响了预防患者护理和疾病。该拟议的索布雷应用程序（如果资助）将有助于减少心血管疾病和代谢危险因素的伯宁，消除健康差异，并改善路易斯安那州和美国普通人群的健康状况。