Male Contraception Research Center Grant

男性避孕研究中心拨款

• 批准号: 9111961
• 负责人: WILLIAM J BREMNER
• 金额: $ 170.56万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-11 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9111961
• 关键词: Address; Biochemical; Cardiovascular Diseases; Cessation of life; Clinical; Contraceptive Agents; Contraceptive Usage; Contraceptive methods; Developing Countries; Female; Genetic; Goals; Grant; Hormonal; Human; Interdisciplinary Study; Knowledge; Male Contraceptive Agents; Population; Reproductive Biology; Reproductive Process; Research; Research Personnel; Research Project Grants; Risk Factors; Science; Societies; Spermatogenesis; Stem cells; Structure; Talents; Training; Unwanted Birth; Unwanted pregnancy; Work; abortion; contraceptive target; design; hormonal contraception; inhibitor/antagonist; male; men; method development; novel; programs; retinaldehyde dehydrogenase; self-renewal; willingness

The work proposed in this application is designed to increase our basic and clinical knowledge of reproductive processes in the male with particular relevance to contraception. The focus of our work is on the biochemical, hormonal and genetic control of mammalian spermatogenesis, including applied studies in normal men, with the goal of developing new, clinically approved contraceptives for men throughout the world. We have four research projects: 1) Novel ALDH1a2 Inhibitors for Male Contraception (Dr. J. Amory, P.I.); 2) Retinaldehyde Dehydrogenases as Male Contraceptive Targets (Dr. M. Griswold, P.I.); 3) Spermatogonial Stem Cell Self-Renewal and Differentiation (Dr. R. Braun, P.I.); and 4) Effects of Male Hormonal Contraceptives on Risk Factors for Cardiovascular Disease (Dr. S. Page, P.I.). We also propose an Administration Core Unit, which includes a Program for Fellows and New Investigators. Our proposal incorporates the talents of outstanding investigators of varied backgrounds and professional training into an interactive research program in reproductive biology. We have structured this Center to meld superb science with the practical goal of applying new basic knowledge as quickly as possible to studies in human beings. We hope that, in this way, our work will address critical needs of society.

本应用程序中提出的工作旨在增加我们对男性生殖过程的基本和临床知识，与避孕特别相关。我们工作的重点是哺乳动物精子发生的生化，激素和遗传控制，包括在正常男性中的应用研究，目的是为全世界的男性开发新的，临床认可的避孕药。我们有四个研究项目：1）新型ALDH1A2男性避孕抑制剂（J. Amory博士，P.I。）； 2）视网膜甲醛脱氢酶作为雄性避孕靶标（M. Griswold，P.I。）； 3）精子干细胞自我更新和分化（R. Braun博士，P.I。）； 4）男性激素避孕药对心血管疾病危险因素的影响（S. Page博士，P.I。）。我们还建议一个管理核心部门，其中包括针对研究员和新调查人员的计划。我们的建议将各种背景和专业培训的杰出研究人员的才华纳入了生殖生物学的互动研究计划。我们已经构建了这个中心，以融合出色的科学，其实用目标是尽快将新的基本知识应用于人类的研究。我们希望这样，我们的工作将满足社会的关键需求。

项目成果

Can inhibition of retinoic acid biosynthesis function as a non-hormonal female contraceptive?

抑制视黄酸生物合成可以作为非激素女性避孕药吗？

• DOI: 10.1016/j.contraception.2018.03.035
• 发表时间: 2018
• 期刊: Contraception
• 影响因子: 2.9
• 作者: Paik,Jisun;Treuting,PiperM;Haenisch,Michael;Amory,JohnK
• 通讯作者: Amory,JohnK

Short-Term Estrogen Withdrawal Increases Adiposity in Healthy Men.

短期雌激素戒断会增加健康男性的肥胖率。

• DOI: 10.1210/jc.2016-1482
• 发表时间: 2016
• 期刊: The Journal of clinical endocrinology and metabolism
• 作者: Chao,Jing;Rubinow,KatyaB;Kratz,Mario;Amory,JohnK;Matsumoto,AlvinM;Page,StephanieT
• 通讯作者: Page,StephanieT

Suppression of spermatogenesis by bisdichloroacetyldiamines is mediated by inhibition of testicular retinoic acid biosynthesis.

• DOI: 10.2164/jandrol.110.010751
• 发表时间: 2011-01
• 期刊: Journal of andrology
• 作者: Amory JK;Muller CH;Shimshoni JA;Isoherranen N;Paik J;Moreb JS;Amory DW Sr;Evanoff R;Goldstein AS;Griswold MD
• 通讯作者: Griswold MD

EGR4 displays both a cell- and intracellular-specific localization pattern in the developing murine testis.

• DOI: 10.1002/dvdy.22442
• 发表时间: 2010-11
• 期刊: DEVELOPMENTAL DYNAMICS
• 影响因子: 2.5
• 作者: Hogarth, Cathryn A.;Mitchell, Debra;Small, Christopher;Griswold, Michael
• 通讯作者: Griswold, Michael

Androgen synthesis in the gonadotropin-suppressed human testes can be markedly suppressed by ketoconazole.

酮康唑可以显着抑制促性腺激素抑制的人类睾丸中的雄激素合成。

• DOI: 10.1210/jc.2012-3527
• 发表时间: 2013
• 期刊: The Journal of clinical endocrinology and metabolism
• 作者: Roth,MY;Nya-Ngatchou,JJS;Lin,K;Page,ST;Anawalt,BD;Matsumoto,AM;Marck,BT;Bremner,WJ;Amory,JK
• 通讯作者: Amory,JK