Genetic and Biochemical Mechanisms of Regulation

遗传和生化调节机制

• 批准号: 9073490
• 负责人: SUSAN THOMAS LOVETT
• 金额: $ 36.88万
• 依托单位: BRANDEIS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1975
• 资助国家: 美国
• 起止时间: 1975-07-01 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9073490
• 关键词: Biochemical; Genetic; Regulation

 DESCRIPTION (provided by applicant): This project will support the training of eight students annually at Brandeis University in the field of genetics, most of whom will be appointed in the second year of their Ph. D. training. Students will be engaged in genetics research relating to molecular, cell, and developmental biology and neuroscience, with relevance to the mechanisms and treatment of human disease. The Training Grant Faculty are drawn from highly collaborative and interdisciplinary researchers in the Departments of Biology, Biochemistry and Chemistry. Students work in well-funded and productive laboratories that are supported by recently upgraded core facilities in DNA and protein analysis, proteomics, genomics, microscopy and mouse and viral transgenics. The proposed program emphasizes rigorous training to develop research and other skills including scientific literacy, writing and oal communication and quantitative approaches. The Ph. D. program has a core curriculum of molecular biology, cell biology and ethics and advanced genetics courses, which includes molecular genetics, neurogenetics, population genetics and genomics, epigenetics and human genetics. These core courses are supplemented by elective courses in biochemistry, structural biology, developmental biology, mathematical modeling or neuroscience and courses concerning human diseases such as cancer, infectious disease, neurological and development disorders. Trainees are appointed based on the strength of their academic records and research potential and are supported for two years. Their progress is closely monitored by a committee of Training Grant Faculty selected for each student. Qualifying examinations at the end of the first and second years provide a means to evaluate each student's ability to frame questions and propose research solutions in their emerging area of expertise and in an outside field. The training of students is supplemented by seminars and journal clubs, featuring a wide variety of successful investigators in diverse areas of biological research. Professional development activities feature individual development plans and valuable personal discussions that assist each student's career planning. A new facet of the program is the expansion of skills workshops, aimed at enhancing trainees' master of specific quantitative approaches and fellowship/grant writing skills. Special opportunities for Trainees include enhanced personal interactions with speakers and participation in an annual Genetics Symposium. In addition, Trainees work with Training faculty in the planning and implementation of these activities. The program is assessed yearly through online surveys and personal discussions with Trainees. This, and the small size and interconnectedness of students and faculty, provides training responsive to the needs of each student in a first-class research setting.

 描述（由适用提供）：该项目将在遗传学领域的布兰代斯大学每年对八名学生进行培训，其中大多数将在其博士学位培训的第二年任命。与分子，细胞和发育生物学和神经科学有关的遗传学研究将与与人类疾病的机制和治疗有关。培训赠款教师来自生物学，生物化学和化学部门的高度协作和跨学科研究人员。学生从事良好资金和产品实验室的工作，这些实验室在DNA和蛋白质分析，蛋白质，基因组学，显微镜和小鼠以及病毒转化方面得到了升级的核心设施的支持。拟议的计划强调了严格的培训，以发展研究和其他技能，包括科学素养，写作和OAL沟通和定量方法。 Ph。D.计划具有分子生物学，细胞生物学和伦理学以及晚期遗传学课程的核心课程，其中包括分子遗传学，神经遗传学，种群遗传学和基因组学，表观遗传学和人类遗传学。这些核心课程由生物化学，结构生物学，发育生物学，数学建模或神经科学以及有关人类疾病（例如癌症，传染病，神经系统和发育障碍）的课程补充。学员是根据他们的学术记录和研究潜力的力量任命的，并得到了两年的支持。他们为每个学生选择的培训赠款委员会密切监视他们的进步。在第一年和第二年结束时进行合格考试提供了一种评估每个学生在新兴专业知识和外部领域中构架问题和提案研究解决方案的能力的方法。对学生的培训补充了Seminars和Journal Clubs，其中包括生物学研究的潜水员领域的各种各样的成功研究者。专业发展活动具有个人发展计划和有价值的个人讨论，可帮助每个学生的职业计划。该计划的一个新方面是扩展技能研讨会，旨在增强受训者的特定定量方法和奖学金/授予写作技能的主人。学员的特殊机会包括增强的与演讲者的个人互动以及参加年度遗传学研讨会。此外，学员在计划和实施这些活动的情况下与培训教师合作。该计划每年通过在线调查和与学员的个人讨论进行评估。这以及学生和教师的规模和相互联系的小规模和相互联系，在一流的研究环境中响应了每个学生的需求的培训。