UNC Neuroscience Center Research Cores

北卡罗来纳大学神经科学中心研究核心

• 批准号: 8978343
• 负责人: WILLIAM D SNIDER
• 金额: $ 48.64万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2017-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8978343
• 关键词: Angelman Syndrome; Animal Model; Area; Bioinformatics; Biological Assay; Biology; Brain Diseases; Cells; Chemicals; Consultations; Core Facility; Development; Disease; Faculty; Funding; Generations; Genomics; Grant; Housing; Image; Instruction; Investments; Libraries; Massive Parallel Sequencing; Modeling; Molecular; Mus; National Institute of Neurological Disorders and Stroke; Neurons; Neurosciences; Neurosciences Research; Pain; Pharmaceutical Chemistry; Preparation; Process; Publishing; Recombinant adeno-associated virus (rAAV); Regulation; Research; Research Personnel; Research Support; Scientist; Services; System; Technical Expertise; Techniques; Training; United States National Institutes of Health; Wages; addiction; assay development; base; chronic pain; disease mechanisms study; embryonic stem cell; equipment acquisition; improved; medical schools; mouse model; myelination; nervous system disorder; neurogenetics; next generation sequencing; operation; screening; translational neuroscience; vector

The purpose of "UNC Neuroscience Center Research Cores" is to enable breakthroughs in the treatment of neurological diseases. For the past nine years, this Center Grant has provided high level technical expertise and Core facilities supporting many NINDS-funded investigators at UNC-Chapel Hill, as well as other NIHfunded neuroscientists with projects related to NINDS priorities. The Cores have also supported numerous young investigators who have subsequently obtained NINDS or other NIH funding. Core services have focused on genomics, generation of mouse models, and confocal/multiphoton imaging. In the current funding period, we added an Assay Development Core that has provided our Center Cores with a key translational component. Access to state of the art techniques has allowed NINDS-funded and other neuroscientists to publish breakthrough research with strong translational relevance in the areas of neurogenetic diseases, brain development, pain, dopaminergic mechanisms, addiction, neuronal/glial interactions, and regulation of myelination. Our Center Grant has also facilitated the development of potential new treatments for Angelman Syndrome and chronic pain. UNC Neuroscience Research Cores have enjoyed strong institutional support with the UNC School of Medicine (SOM) continuously providing space to house the Cores, appropriate salary fractions for Faculty Directors, some salary support for research scientist Core Directors, and support for major equipment purchases during the past funding period. Further, our NINDS funded Cores leverage major investments that UNC has made in generation of animal models, massively parallel (next generation) sequencing, and highthroughput screening and chemical biology. For the competitive renewal, we will expand and enhance molecular services to support animal model generation and massively parallel sequencing. We request support for a Bioinformatics Core rather than for continued operation of an Affymetrix facility. Affymetrix services are now self-sufficient and will be taken over by the UNC School of Medicine. We propose enhancement and continued operation of our Confocal and Multiphoton Imaging Core. Our assay development core has been improved and renamed Translational Neuroscience. These Cores will support 15 NINDS-funded projects, projects of 13 other NIH - funded neuroscientists, and 7 young investigators who do not yet have R01 funding. As a group UNC Neuroscience Center Research Cores will allow NINDS-funded and other UNC neuroscientists seamlessly to generate mice for studies of fundamental mechanisms or disease process, perform state of the art imaging and bioinformatics analysis on these models, and finally to develop assays that can be used to advance new treatments for neurological diseases.

“ UNC神经科学中心研究核心”的目的是在神经疾病的治疗方面取得突破。在过去的九年中，该中心拨款提供了高水平的技术专业知识和核心设施，为UNC-Chapel Hill的许多由Ninds资助的调查员以及其他NIHUND提供了支持 神经科学家与NINDS优先事项有关的项目。核心还支持众多随后获得Ninds或其他NIH资金的年轻调查员。核心服务集中在基因组学，小鼠模型的产生和共聚焦/多光子成像上。在当前的资金期间，我们添加了一个测定开发核心，该核心为我们的中心核心提供了关键的翻译 成分。 获得最先进的技术使NINDS资助的和其他神经科学家能够在神经遗传疾病，大脑发育，疼痛，多巴胺能机制，成瘾，神经/神经胶质相互作用和髓鞘率调节方面发表突破性研究。我们的中心赠款还促进了对安吉尔曼综合症和慢性疼痛的潜在新疗法的发展。 UNC神经科学研究核心核心在UNC医学院（SOM）不断提供了强大的机构支持，该学院不断提供容纳核心的空间，适合教师董事的适当薪资部分，对研究科学家核心董事的一些薪水支持以及在过去的资金期间对大型设备购买的支持。此外，我们的NINDS资助的核心利用了重大投资 UNC在动物模型的产生中进行了大规模平行（下一代）测序以及高通量筛查和化学生物学。 对于竞争性更新，我们将扩展和增强分子服务，以支持动物模型的产生和大规模平行测序。我们要求支持生物信息学核心，而不是继续操作Affymetrix设施。 Affymetrix服务现在是自给自足的，将由UNC医学院接管。我们提出了共同焦点的增强和继续操作 多光子成像核心。我们的测定开发核心已得到改善并更名为翻译神经科学。这些核心将支持15个由NINDS资助的项目，其他13个NIH资助的神经科学家的项目，以及7名尚未拥有R01资金的年轻调查员。 作为一个组，UNC神经科学中心的研究核心将允许NINDS资助和其他UNC神经科学家无缝地生成小鼠，以研究基本机制或疾病过程，对这些模型进行艺术成像的状态和生物信息学分析，并最终开发可用于推进神经学疾病的新治疗方法。