Air Pollution Exposure during Pregnancy, Maternal Glycemia, and Offspring Growth

怀孕期间的空气污染暴露、母亲血糖和后代生长

基本信息

批准号：
9084562
负责人：
Abby Fleisch
金额：
$ 4.28万
依托单位：
BOSTON CHILDREN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-07-01 至 2016-10-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9084562
关键词：
3 year old Accounting Adverse effects Air Air Pollution Area Attention Automobile Exhaust Biological Markers Biometry Birth Birth Weight Boston Burn injury Caliber Carbon Black Child Child health care Childhood Clinical Cohort Studies Comorbidity Complex Data Diet Endocrinology Environmental Epidemiology Environmental Exposure Environmental Health Environmental Policy Epidemic Epidemiology Exposure to Familiarity Fatty acid glycerol esters Fetal Growth Genetic Gestational Age Growth Habits Health Healthcare Heating Hormonal Hospital Departments Human Hyperglycemia Indoor Air Pollution Infant Insulin Resistance Intervention K-Series Research Career Programs Knowledge Lead Leptin Leptin resistance Life Link Measures Medicine Mentors Mentorship Modeling Monitor Mothers New England New Hampshire Obesity Outcome Pattern Pediatric Hospitals Perinatal Physical activity Physicians Policies Pollution Population Pregnancy Pregnant Women Prevention Prevention Research Principal Investigator Process Public Health Public Health Schools Research Research Personnel Resources Risk Factors Rodent Rodent Model Rural Serum Source Staging Statistical Methods Statistical Models Techniques Testing Time Toxic Environmental Substances Training Weight Weight Gain Wood material Wood stove Work adiponectin air filter ambient air pollution base career cohort collaborative environment cooking disorder prevention disorder risk early childhood ethnic minority population high risk indoor exposure infancy insight medical schools obesity in children offspring particle pollutant population based postnatal prenatal prenatal exposure prospective public health intervention racial and ethnic response skills solid fuel trafficking

项目摘要

DESCRIPTION (provided by applicant): Childhood obesity is a global epidemic with costly comorbidities. In the US, the rate of obesity has tripled over the past 40 years. Diet, physical activity, and genetics do not explain all of the variability in weight, and moreover can be difficut to modify. Identifying environmental triggers and feasible public health interventions is therefore a policy imperative. Prior data from this team has suggested an association of prenatal exposure to air pollution with maternal hyperglycemia and reduced fetal growth. Paradoxically we have also demonstrated an association between greater prenatal traffic-related pollution and excess infant weight gain after birth, leading to higher risk for obesity in infancy. With the guidance of my mentoring team, during this 5 year K23 career development award, the Candidate will leverage data from two prospective longitudinal cohorts of mothers and children (Project Viva, n=2,128 and the New Hampshire Birth Cohort Study (NHBCS), n=1,500) to extend this prior work through three inter-related projects. The Principal Investigator will: (1) examine prenatal exposure to ambient air pollution as a risk factor for rapid weight trajectories throughout childhood and central fat accrual in mid-childhood. (2) consider the relationship of prenatal air pollution exposure with obesity-associated hormonal biomarkers, including leptin, adiponectin, and insulin resistance in childhood. (3) characterize exposures and habits related to indoor sources of air pollution in rural New England and estimate the extent to which indoor wood burning during pregnancy is associated with maternal hyperglycemia, fetal growth, and offspring weight gain in early childhood. The training plan proposed will build upon my clinical training in pediatric endocrinology and basic knowledge of biostatistics and epidemiology to provide formal training in (1) environmental exposure assessment, (2) statistical techniques necessary to analyze complex exposure-response relationships, and (3) the practical skills necessary to lead a research team. The Candidate will leverage the wealth of resources available at Boston Children's Hospital, the Department of Population Medicine (Harvard Medical School and Harvard Pilgrim Health Care), the Harvard School of Public Health, and the Dartmouth Children's Environmental Health and Disease Prevention Research Center to conduct the proposed analyses. These studies and training will lay the necessary scientific framework to launch her career as an independent physician researcher studying the impact of environmental toxicants on children's health, with a focus on obesity and insulin resistance.

描述（由适用提供）：儿童肥胖是一种全球流行病，具有昂贵的合并症。在美国，肥胖速度在过去40年中增加了两倍。饮食，体育锻炼和遗传学并不能解释体重的所有变异性，而且很难修改。因此，确定环境触发因素和可行的公共卫生干预措施是政策势在必行。该团队的先前数据表明，在产前暴露于空气污染与孕产妇高血糖和胎儿生长降低的关联。矛盾的是，我们还证明了与产前交通相关的污染更大的污染与出生后婴儿体重的增长之间的关联，从而导致婴儿期肥胖的风险更高。在我的心理团队的指导下，在这5年的K23职业发展奖中，候选人将利用来自两个前瞻性纵向同伙的母亲和儿童的数据（Viva Project Viva，n = 2,128和New Hampshire出生队列研究（NHBCS），NHBCS，n = 1,500），n = 1,500），将这项先前的工作扩展到三个相互授权的项目。首席研究者将：（1）检查产前暴露于环境空气污染，作为整个儿童期重量轨迹的危险因素，而中央则在中期期中。（2）考虑产前空气污染的暴露与肥胖相关的骑马者（包括瘦素，脂联素和儿童胰岛素抵抗）的关系。（3）表征与新英格兰农村地区空气污染来源相关的暴露和习惯，并估计怀孕期间室内燃烧的程度与孕产妇高血糖，胎儿生长和后代体重增加有关。提出的培训计划将基于我在儿科内分泌学方面的临床培训以及生物统计学和流行病学的基本知识，以在（1）环境暴露评估中提供正式培训，（2）分析复杂的统计技术，以分析复杂的暴露 - 响应关系，以及（3）领导研究团队所需的实用技能。候选人将利用波士顿儿童医院，人口医学系（哈佛医学院）和哈佛朝圣者卫生保健，哈佛公共卫生学院以及达特茅斯儿童环境健康和预防疾病预防研究中心可用的大量资源。这些研究和培训将奠定必要的科学框架，以启动她作为独立的物理研究人员的职业生涯，研究环境有毒者对儿童健康的影响，重点是肥胖和胰岛素抵抗。