Dietary factors and risk of uterine fibroids

饮食因素与子宫肌瘤的风险

• 批准号: 9387803
• 负责人: Holly Ruth Harris
• 金额: $ 3.91万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9387803
• 关键词: Dietary; factors; risk; uterine; fibroids

 DESCRIPTION (provided by applicant): Uterine leiomyoma (UL) are the most common pelvic tumor in women of reproductive age. Despite the fact that these smooth muscle tumors are benign, UL are a significant public health problem, accounting for over 200,000 hysterectomies annually, and approximately 1 in 4 women will have a UL that comes to clinical attention. Despite the high morbidity and health care costs associated with UL, the etiology is not understood, and few modifiable, protective risk factors have been identified. Dietary factors may play a role in UL etiology due to their potential to modify endogenous hormones as well as their inflammatory effects. Hypothesis/Specific Aims: Our overall hypothesis is that intake and plasma biomarker levels of dietary components that influence endogenous hormonal and inflammatory response are associated with UL risk. Few studies have examined the association between dietary factors and UL. To our knowledge, only one prospective cohort has examined the association between dairy and dietary fat intake and UL observing a reduced risk of UL with increasing dairy consumption and associations with some fatty acids. In addition, no prospective studies have examined the association with vitamin D levels. Using prospective data we will evaluate the following aims: Aim 1. Evaluate the association between dietary fat and risk of incident uterine leiomyoma using data among 97,807 women in the NHSII cohort who completed a dietary assessment. In a subset of these women we will examine the association between circulating fatty acid levels and uterine leiomyoma. Aim 2. Dairy food intake is associated with risk of uterine leiomyoma. Aim 3. Vitamin D levels are associated with risk of uterine leiomyoma. Study Design: The proposed study consists of Nurses' Health Study II participants who completed a food frequency questionnaire (FFQ) about their usual diet in 1991. Follow-up FFQs were completed in 1995, 1999, 2003, and 2007. Quintiles or categories of dietary intake will be generated and Cox proportional hazards models will be used to estimate hazard ratios of UL incidence associated with each of the dietary factors. Among a subset of women with pre-diagnostic biomarkers, the association between plasma vitamin D and circulating fatty acids with UL risk will be assessed with logistic regression models. The presence of prospectively collected UL, dietary, and covariate data and stored blood samples, allows cost-efficient and valid consideration of the temporality of disease diagnosis - supporting the potential identification of modifiable risk factors.

 描述（由适用提供）：子宫平滑肌瘤（UL）是生殖年龄妇女中最常见的骨盆肿瘤。尽管这些平滑肌肿瘤是良性的，但UL是一个重大的公共卫生问题，每年占超过200,000个子宫切除术，大约有4个女性中有1个女性会引起临床关注。尽管与UL相关的发病率和医疗保健成本很高，但病因却没有理解，很少有可修改的，受保护的风险因素。饮食因素可能在UL病因中起作用，因为它们有可能修饰内源性骑马及其炎症作用。假设/特定目的：我们的总体假设是，摄入和血浆生物标志物水平的饮食成分水平影响内源性horsemenal和炎症反应与UL风险有关。很少有研究检查饮食因素与UL之间的关联。据我们所知，只有一个前瞻性队列研究了乳制品和饮食脂肪摄入量之间的关联，并且UL观察到乳制品消耗的增加和与某些脂肪酸的关联的风险降低。此外，尚无前瞻性研究检查与维生素D水平的关联。使用前瞻性数据，我们将评估以下目的：目标1。使用完成饮食评估的NHSII队列中的97,807名妇女中的数据，评估饮食脂肪与发生子宫平滑肌瘤的风险之间的关联。在这些女性的子集​​中，我们将检查循环脂肪酸水平与子宫平滑肌瘤之间的关联。目标2。乳制品摄入与子宫平滑肌瘤的风险有关。 AIM3。维生素D水平与子宫平滑肌瘤的风险有关。 Study Design: The proposed study consists of Nurses' Health Study II participants who completed a food frequency questionnaire (FFQ) about their usual diet in 1991. Follow-up FFQs were completed in 1995, 1999, 2003, and 2007. Quintiles or categories of dietary intake will be generated and Cox proportional hazards models will be used to estimate hazard ratios of UL incidents associated with each of the dietary factors.在诊断前生物标志物的一部分女性中，血浆维生素D与循环脂肪酸与UL风险之间的关联将通过逻辑回归模型进行评估。前瞻性收集的UL，饮食和协变量数据以及储存的血液样本的存在，允许对疾病诊断的暂时性进行成本效益且有效的考虑 - 支持潜在的可修改风险因素的鉴定。