Endogenous Mitochondria Resistance to Acute Kidney Injury

内源性线粒体对急性肾损伤的抵抗力

基本信息

批准号：
8971622
负责人：
ROBERT L BACALLAO
金额：
--
依托单位：
RLR VA MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-10-01 至 2018-09-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8971622
关键词：
3-hydroxy-3-methylglutaryl-coenzyme A Acute Kidney Failure Acute Renal Failure with Renal Papillary Necrosis Address Admission activity Aging Amino Acids Animal Model Anions Biochemical Biological Preservation Biology Brain Hypoxia-Ischemia Cell Culture Techniques Cell Death Cell physiology Cells Cessation of life Citrates Citric Acid Cycle Communities Complex Complication Consomic Strain Data Diabetes Mellitus Dialysis procedure Disease Dose Electrons End stage renal failure Event Experimental Models Gene Targeting Generations Genetic Genetic Models Glucose Glutarates Health Hospitalization Hospitals Hypertension Hypoxia In Vitro Injury Injury to Kidney Ischemia Ischemic Preconditioning Isocitrates Kidney Kidney Diseases Knowledge Label Lead Life Lipids Maintenance Malignant Neoplasms Mass Spectrum Analysis Minor Mitochondria Mitochondrial Proteins Modality Modeling Modification Molecular Morbidity - disease rate NADP Norway Organism Oxidative Phosphorylation Oxygen Consumption Pathway interactions Physiological Population Process Production Property Proteins Proteomics Proximal Kidney Tubules Rattus Rattus norvegicus Reaction Reactive Oxygen Species Regulation Renal function Reperfusion Injury Reperfusion Therapy Research Personnel Resistance Risk Sentinel Severities Signal Pathway Site Source Speed Stress Structure Succinates System Testing Therapeutic Intervention Tissues United States National Institutes of Health Yeasts cell injury cost drug discovery free radical oxygen hemodynamics improved in vitro Model in vivo injury and repair mortality mortality statistics novel strategies preconditioning prevent protective effect protein expression protein profiling public health relevance repaired research study respiratory response screening statistics targeted treatment therapeutic target trait transgene expression

项目摘要

DESCRIPTION (provided by applicant): Acute kidney injury (AKI) occurs in 5-7% of all hospital admissions and recent evidence has shown that even minor changes in renal function are associated with increased risk of death. In the ICU, AKI is associated with 50% mortality, a statistic which has not changed even with dialysis therapy. In fact the Acute Renal Failure Trial Network study, a combined VA and NIH sponsored dialysis dosing study, showed no change in mortality statistics when comparing dialysis dosing. Clearly new approaches are urgently needed to address this life-threatening disease. Given the fact that the VA population is aging, prone to diabetes and hypertension, AKI is a major health problem in this group. Upon completion of this VA Merit Review, investigators in the renal community will have new targets for small molecular drug discovery that should ameliorate the mortality associated with AKI.

描述（由申请人提供）：急性肾损伤 (AKI) 占所有入院病例的 5-7%，最近的证据表明，即使肾功能发生微小变化，也会增加死亡风险。在 ICU 中，AKI 与 50% 的死亡率相关，即使进行透析治疗，这一统计数据也没有改变。事实上，急性肾衰竭试验网络研究（VA 和 NIH 联合资助的透析剂量研究）显示，在比较透析剂量时，死亡率统计数据没有变化。显然，迫切需要新的方法来解决这种危及生命的疾病。鉴于退伍军人人口正在老龄化，容易患糖尿病和高血压，AKI 是该群体的一个主要健康问题。 VA 优异评审完成后，肾脏界的研究人员将找到小分子药物发现的新目标，从而降低 AKI 相关的死亡率。