Fundamental Biobehavioral Mechanisms Underlying the Integrated Development of Emotion, Attachment, and Nutritive Intake in the Mother-Infant Dyad

母婴二元情感、依恋和营养摄入综合发展的基本生物行为机制

• 批准号: 10583348
• 负责人: Julie C Lumeng
• 金额: $ 75.77万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2028-02-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10583348
• 关键词: 3 year old; Adult; Affective; Behavior; Biology; Birth; Child; Childhood; Compensation; Cues; Development; Dietary intake; Distress; Eating; Eating Behavior; Emotional; Emotions; Exposure to; Face; Feeding behaviors; Food; Future; Goals; Growth; Heart Rate; Hunger; Hydrocortisone; Hyperphagia; Infant; Intake; Learning; Life; Link; Literature; Longevity; Methods; Milk; Modeling; Mothers; Obesity; Opioid; Oxytocin; Physiology; Randomized, Controlled Trials; Reporting; Research; Rewards; Risk Factors; Satiation; Social Environment; Social Interaction; Stimulus; Stress; Sucrose; System; Systems Integration; Testing; Weight Gain; Work; behavioral response; biobehavior; caregiving; cohort; eating in absence of hunger; feeding; hedonic; infancy; infant adiposity; maternal caregiving; novel; nutrition; obesity in children; pain relief; predicting response; preference; response; stressor; theories; therapy development; willingness

PROJECT SUMMARY The rate of weight gain in the first year of life is a robust risk factor for future obesity. The use of food to soothe has been linked to greater weight gain and has been theorized to contribute to future reward-driven or emotional overeating. However, avoiding the use of food to soothe is challenging for mothers, particularly for children who are less easily soothed by other strategies. Conceptual models to date have viewed infant distress due to hunger as distinct from infant distress due to other causes. These models encourage a separation of food as nutrition from food as soothing. However, diverse literatures converge to suggest that emotion, mother-infant attachment, maternal feeding, and infant eating behavior are appropriately intertwined and co-develop in adaptive ways. This proposal seeks to test an entirely novel comprehensive model of bidirectional biobehavioral mechanisms underlying the development of an integrated system of emotion, attachment, and nutritive intake in the mother-infant dyad across birth, 3 months, and 6 months. Further, we propose to test the association of this system with maternal feeding behavior, child eating behavior, dietary intake, and adiposity to age 3 years. Using novel experimental methods in a cohort of 120 children, we will address the following aims: Aim 1: To test the cross-lagged associations of maternal-infant dyadic stress physiology and maternal-infant dyadic oxytocin physiology with feeding to soothe and infant adiposity. H1a: Greater maternal and infant cortisol response and heart rate elevation in response to an infant stressor predicts more use of feeding to soothe and greater infant adiposity. H1b: Lower maternal and infant oxytocin response to caregiving predicts greater use of feeding to soothe, and greater infant adiposity. Aim 2: To test the cross-lagged associations of sucrose effects on infant opioid physiology with feeding to soothe and infant adiposity. H2: Behavioral response to sucrose characterized by greater relief of pain, greater relief of distress, and greater hedonic response predicts greater use of feeding to soothe and greater infant adiposity. Aim 3: To test the cross-lagged associations of the potency of maternal social interaction effects on infant eating with feeding to soothe and infant adiposity. H3: Greater effect of social interaction on increasing infant willingness to work for food, reducing capacity for caloric compensation, and relieving distress following a feeding delay predicts greater use of feeding to soothe and greater infant adiposity. Aim 4: To test the association of the ‘emotion-attachment- nutritive intake-system’ in infancy with maternal feeding behavior, child eating behavior, child dietary intake, and child adiposity at age 3 years. H4: Greater maternal-infant dyadic stress physiology, lower maternal-infant dyadic oxytocin physiology, greater sucrose effects on infant opioid physiology, and greater potency of maternal social interaction effects on eating in infancy predicts greater indulgent feeding, eating in the absence of hunger, overeating following caloric preload, reinforcing value of food, affective response to food delay, dietary intake of sweets, and adiposity at age 3 years.

项目概要 出生后第一年的体重增加率是未来肥胖的一个重要危险因素。 与更大的体重增加有关，并且理论上有助于未来的奖励驱动或 然而，避免用食物来安抚情绪对母亲来说是一个挑战，尤其是对母亲来说。 迄今为止，不太容易通过其他策略安抚的儿童已经观察过婴儿。 饥饿引起的痛苦与其他原因引起的婴儿痛苦不同，这些模型鼓励婴儿的痛苦。 将营养食品与舒缓食品分开 然而，不同的文献一致认为这一点。 情绪、母婴依恋、母亲喂养和婴儿饮食行为适当地交织在一起 该提案旨在测试一种全新的综合模型。 情绪综合系统发展的双向生物行为机制， 母婴二人在出生、3个月和6个月期间的依恋和营养摄入。 建议测试该系统与母亲喂养行为、儿童饮食行为、膳食 我们将使用新颖的实验方法对 120 名儿童进行研究。 实现以下目标： 目标 1：测试母婴二元压力的交叉滞后关联 生理学和母婴二元催产素生理学与喂养舒缓和婴儿肥胖 H1a： 对婴儿压力源的反应更强的母婴皮质醇反应和心率升高 预测更多地使用喂养来缓解和增加婴儿肥胖 H1b：降低母婴催产素。 对护理的反应预示着更多地使用喂养来舒缓情绪，以及更多的婴儿肥胖。 蔗糖对婴儿阿片类生理学影响与喂养安抚和婴儿的交叉滞后关联 H2：对蔗糖的行为反应，其特征是更大程度地缓解疼痛、更大程度地缓解痛苦， 更大的享乐反应预示着更多地使用喂养来缓解和更大的婴儿肥胖。 测试母亲社会互动对婴儿饮食影响效力的交叉滞后关联 H3：社交互动对增加婴儿的意愿有更大的影响。 为食物而工作，降低热量补偿能力，并缓解进食延迟后的痛苦 预测更多地使用喂养来缓解和增加婴儿肥胖 目标 4：测试两者之间的关联。 婴儿期的“情感-依恋-营养摄入系统”与母亲喂养行为、儿童饮食行为、 儿童膳食摄入量和 3 岁时儿童肥胖 H4：更大的母婴应激生理学， 较低的母婴二元催产素生理学，蔗糖对婴儿阿片类生理学的影响更大，以及 母亲的社会互动对婴儿期饮食的影响更大，预示着更纵容的喂养， 在没有饥饿的情况下进食、热量预负荷后暴饮暴食、增强食物的价值、情感 3岁时对食物延迟、饮食中甜食摄入和肥胖的反应。