Auditory masking effects on speech fluency in aphasia and apraxia of speech

听觉掩蔽对失语症和言语失用症患者言语流畅性的影响

• 批准号: 8685006
• 负责人: ADAM Patrick JACKS
• 金额: $ 14.3万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8685006
• 关键词: Accounting; Adjuvant; Adult; Affect; Aphasia; Auditory; Behavioral; Betula Genus; Bilateral; Characteristics; Clinical; Communication; Communication impairment; Data; Etiology; Expressive Aphasia; Feedback; Foundations; Future; Goals; Healthcare; Individual; Inferior; Intervention; Investigation; Lesion; Life; Masks; Measures; Methods; Modeling; Motor; Movement; Neurologic; Noise; Outcome Measure; Parietal Lobe; Participant; Pattern; Persons; Process; Production; Quality of life; Relative (related person); Reliance; Research; Response Latencies; Role; Site; Speech; Speech Disorders; Speech Sound; Stroke; Stuttering; Survivors; System; Techniques; Temporal Lobe; Testing; Time; Wolves; Work; aphasic; auditory feedback; base; frontal lobe; improved; motor control; oral communication; prevent; programs; response; speech accuracy; tool

DESCRIPTION (provided by applicant): The objective of this research is to test the effects of listening to noise (i.e. auditory feedback masking) on speech fluency in stroke survivors with aphasia and apraxia of speech. People with nonfluent types of aphasia frequently have apraxia of speech, which affects the motor programming of speech movements, causing distortions, slow rate, and speech disfluencies that impede the forward flow of communication. Speaking while listening to noise (e.g. auditory masking) is known to reduce disfluencies and increase speech rate in people who stutter. This method has been tested in people with aphasia, resulting in positive effects on speech production for a subset of those tested. We contend that individuals who have apraxia of speech in addition to aphasia are most likely to benefit from auditory masking, but most previous studies did not test participants for apraxia of speech. In addition, though masking is most likely to affect speech disfluencies, previous studies did not measures disfluencies. The proposed work has two specific aims. Aim 1 will determine the effect of auditory masking on speech fluency in stroke survivors with aphasia and apraxia of speech. Aim 2 will identify individual factors that predict a positive response, including presence of apraxia of speech, lesion characteristics, and type of aphasia (e.g. Broca's, Wernicke's). Voxel-based lesion analysis techniques will be used to determine sites of lesion associated with positive and negative response to auditory masking. Completion of this study will remove barriers to studying auditory masking as a technique for clinical intervention, but also as a research tool for behavioral neuroscientists probing the speech motor control system in speakers with aphasia and apraxia of speech.

描述（由申请人提供）：这项研究的目的是测试聆听噪声（即听觉反馈掩蔽）对中风幸存者语音流利的影响，并具有失语和语音的言语。患有非流行性失语症的人经常有语音失用，这会影响语音运动的运动编程，导致扭曲，缓慢的速度和言语障碍，从而阻碍了沟通的前进流动。众所周知，在听噪音（例如听觉掩盖）时说话，可以减少疏忽并提高口吃的人的语音率。这种方法已在失语症的患者中进行了测试，从而对一部分被测试的人产生了积极影响。我们认为，除了失语症之外，患有语言失用的人最有可能受益于听觉掩盖，但以前的大多数研究都没有测试参与者的语言失用。此外，尽管掩盖最有可能影响言语疏远，但以前的研究并未衡量探索。拟议的工作有两个具体的目标。 AIM 1将确定听觉掩盖对失语症和语言失语的中风幸存者中语音流利度的影响。 AIM 2将确定预测积极反应的个体因素，包括存在 言语，病变特征和失语症的类型（例如Broca，Wernicke's）的类型。基于体素的病变分析技术将用于确定与听觉掩蔽的正面和负面反应相关的病变位点。这项研究的完成将消除研究听觉蒙版作为临床干预技术的障碍，也将作为一种行为神经科学家的研究工具，该工具探讨了言语的言语和语音失语症的言语控制系统。