ShEEP Acquisition for a LICOR Pearl Trilogy Small Animal Imaging System

LICOR Pearl Trilogy 小动物成像系统的 ShEEP 采集

• 批准号: 9213036
• 负责人: Tammy Angaline Butterick
• 金额: --
• 依托单位: MINNEAPOLIS VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-01 至 2016-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9213036
• 关键词: Accounting; Adipose tissue; Aging; Alzheimer' s Disease; Anesthesia procedures; Anesthetics; Animals; Area; Basic Science; Beds; Biological; Biological Assay; Biological Sciences; Bioluminescence; Bone Tissue; Boxing; Brain; Cardiovascular Diseases; Cardiovascular Physiology; Charcoal; Charge; Color; Complex; Computer software; Computers; Contracts; Coupled; Data; Data Analyses; Detection; Devices; Dimensions; Discipline; Disease; Docking; Equipment; Equipment and supply inventories; Fostering; Functional disorder; Funding; Gases; General Population; Generations; Goals; Gulf War; Health; Healthcare; Heart; Heating; Housing; Image; Immunocompromised Host; Immunology; In Vitro; Information Systems; Injectable; Injection of therapeutic agent; Investigation; Isoflurane; Lasers; Legal patent; Life; Light; Lighting; Liver; Lymphatic; Malignant Neoplasms; Malignant neoplasm of pancreas; Manufacturer Name; Measurement; Measures; Medical; Metabolic Diseases; Microscope; Microscopic; Minor; Modeling; Molecular; Molecular Probes; Nebraska; Nerve Degeneration; Neurosciences; Obesity; Operating System; Operative Surgical Procedures; Optics; Organ; Oxygen; Physiological; Platinum; Procedures; Program Evaluation; Provider; Research; Research Personnel; Resolution; Resources; Rodent; Running; Scanning; Services; Side; Small Animal Imaging Systems; Speed; Staging; System; Technology; Tissue Sample; Tissue Stains; Tissue imaging; Tissues; Training; Translational Research; United States; Validation; Vendor; Veterans; Veterinarians; Viral Vector; Weight; animal imaging; animal tissue; bacterial vector; base; bone; brain tissue; clinically relevant; data format; design; detector; equipment acquisition; experience; high efficiency particulate air filter; imaging platform; imaging system; in vivo; instrument; interest; lens; novel therapeutics; programs; research and development; research study; software systems; solid state; stem cell biology; stem cell therapy; tumor; wasting

We are requesting funds through the Shared Equipment Evaluation Program (ShEEP) under the Research Equipment Management program offered by the Office of Research and Development to acquire a LI-COR Pearl Trilogy Small Animal Imaging Platinum System (manufactured in Lincoln, Nebraska USA, GSA contract number GS-07F-240CA). This comprehensive imaging system allows investigators to measure near-infrared fluorescent and bioluminescent optical probes in live animals, tissue, and in vitro molecular assays. The system acquires images at a high resolution, allowing the study of complex biological interactions within a relevant physiological context. The imaging capabilities of the requested equipment are sensitive enough to visualize deep targets such as brain or bone tissue. Currently, this technology is not available at the Minneapolis VAHCS, nor does our facility have any other equipment with equivalent capabilities. The requested equipment will be housed in a shared dedicated procedure room within the Minneapolis VAHCS Veterinary Medical Unit (VMU), and will be made available to VA investigators as common service equipment. The requested imaging system will compliment an existing inventory of multiuser based instruments with the end goal of increasing efficiency and resources while fostering translational (bench-top to bed-side) research. Dr. Tammy Butterick will oversee the training and usage of the equipment under the full support of Minneapolis VAHCS Director (Mr. Patrick J. Kelly), the Research & Development Committee Chair (Dr. Ronald Bach), and the VMU veterinarian (Dr. Matthew Rassette). The fields of interest of major and minor user groups for this equipment span multiple VA research disciplines, and collectively represent both basic and translational research in areas such as aging, cardiovascular disease, cancer, neuroscience, stem cell therapies, Gulf War Illness, and obesity. The identified VA funded major users will account for at least 75% of the instrument capacity. The minor users group will occupy 25% or less of the instrument capacity. If the Minneapolis VAHCS is to remain one of the largest and most active research programs in the VA system, it is critical for our investigators to gain access to the newest generation of high-sensitivity, high-resolution instruments. The acquisition of the LI-COR Pearl Platinum System would accelerate and enhance the rate in which researchers from multiple disciplines can acquire, analyze, display, and understand data, with the long-term goal of benefiting the unique health care needs of US Veterans. We are confident that acquisition of this equipment will enhance and extend the clinical relevance of ongoing investigations in our facility, and will generate new collaborative efforts to develop treatments or therapies for diseases relevant to the health care needs of Veterans and to the general public.

我们正在通过研究中的共享设备评估计划（SHEEP）要求资金 研发办公室提供的设备管理计划以获取LI-COR 珍珠三部曲小动物成像白金系统（美国内布拉斯加州林肯制造，GSA合同 数字GS-07F-240CA）。这个全面的成像系统允许研究人员测量近红外 活动物，组织和体外分子测定中的荧光和生物发光光学探针。这 系统以高分辨率获取图像，从而允许研究复杂的生物学相互作用 相关的生理环境。请求的设备的成像功能足够敏感 可视化脑或骨组织等深层目标。目前，该技术在 明尼阿波利斯VAHC，我们的设施也没有其他具有同等功能的设备。这 所请求的设备将安置在明尼阿波利斯VAHC的共享专用程序室里 兽医医疗部门（VMU），将作为普通服务设备提供给VA调查人员。 所请求的成像系统将为多元仪器的现有库存与 提高效率和资源的最终目标，同时促进翻译（卧床式卧床）研究。 塔米·巴特里克（Tammy Butterick）博士将在明尼阿波利斯的全部支持下监督设备的培训和使用 VAHCS董事（Patrick J. Kelly先生），研发委员会主席（Ronald Bach博士）和 VMU兽医（Matthew Rassette博士）。主要用户和次要用户群体感兴趣的领域 设备涵盖了多个VA研究学科，并共同代表基本和翻译 在衰老，心血管疾病，癌症，神经科学，干细胞疗法，海湾战争等领域的研究 疾病和肥胖。已确定的VA资助的主要用户至少占该工具的75％ 容量。次要用户组将占据仪器容量的25％或更低。如果明尼阿波利斯VAHCS 是成为VA系统中最大，最活跃的研究计划之一，这对我们来说至关重要 调查人员可以获取最新一代的高敏性高分辨率工具。这 采集Li-Cor珍珠白金系统将加速并提高研究人员的速度 从多个学科中可以以长期目标获取，分析，显示和理解数据 从而使美国退伍军人的独特医疗保健需求受益。我们有信心收购此设备 将增强和扩展我们工厂正在进行的调查的临床相关性，并将产生新的 为开发与医疗保健需求有关的疾病的治疗或疗法的协作努力 退伍军人和公众。