Hybrid organometallic_carbon nanotube films for enhanced chemiresistive sensors

用于增强化学电阻传感器的混合有机金属碳纳米管薄膜

• 批准号: 9027694
• 负责人: Sibo Lin
• 金额: $ 5.43万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-02-04 至 2018-02-03
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9027694
• 关键词: Acetone; Acetonitriles; Address; Advanced Development; Air; Asthma; Biochemistry; Biological Markers; Calibration; Canis familiaris; Carbon Dioxide; Carbon Monoxide; Carbon Nanotubes; Cells; Chemicals; Complex Mixtures; Consumption; Deposition; Detection; Development; Devices; Diagnosis; Diagnostic; Disease; Electrodes; Electronic Mail; Electronics; Ethanol; Ethylenes; Evolution; Exhalation; Exhibits; Exposure to; Face; Film; Fingerprint; Formaldehyde; Gas Chromatography; Gases; Goals; Gold; Health; Healthcare; Heart failure; Human body; Hybrids; Hydrogen; Individual; Indoor pollutant; Lead; Ligands; Location; Malignant neoplasm of lung; Mass Fragmentography; Measurement; Measures; Medical; Metals; Methanol; Monitor; Nanotubes; Nitrogen; Nose; Oxidation-Reduction; Oxygen; Patients; Persons; Research; Rest; Sampling; Smell Perception; Staging; Stream; Synthesis Chemistry; Techniques; Technology; Testing; Time; Toxic effect; Training; Water; Work; absorption; accurate diagnosis; base; chemical fingerprinting; cost; cost effective; design; disease diagnosis; infrared spectroscopy; instrumentation; nanoparticle; next generation; portability; prevent; public health relevance; response; screening; sensor; single walled carbon nanotube; vapor; volatile organic compound

 DESCRIPTION (provided by applicant): This proposal describes the development of portable, cost-effective, and energy-efficient chemical sensors for detection of carbon monoxide, formaldehyde, methanol, ethanol, acetone, and hydrogen. Sensing these volatile compounds could both prevent and diagnose health problems. Some diseases are attributed to exposure to low levels of a volatile compound. For instance, formaldehyde, a common indoor pollutant, has been correlated with asthma rates. On the other hand, the human body exhales a set of molecules containing diagnostic information on the health of the individual. For example, trained dogs can detect lung cancer by the smell of a person's breath. Cost-effective and low-powered gas sensors could be deployed in an always-on networked array to prevent exposure to harmful chemicals; portability could extend application of gas sensors to monitoring personal health, which could revolutionize breath vapor analysis in health care. Current sensor technologies are limited. While gas chromatography is the gold standard for accurately identifying trace compounds, the instrumentation is costly and requires specialized training to operate. Other platforms to detect volatiles (fuel cells, infrared spectroscopy, etc.) may be simpler to operate, but face problems with sensitivity, selectivity, cost, and power consumption. To tackle these issues, an "electronic nose" strategy has been explored in which an array of sensors is utilized in concert to determine the chemical fingerprint of a vapor sample. In particular, Swager and coworkers have investigated resistive sensors based on functionalized carbon nanotube networks, potentially leading to inexpensive, low-powered, robust, and portable chemical sensors. Further improvements in sensitivity and selectivity of these sensors could lead to commercially viable devices. The goal of this research is to make a network of single-walled carbon nanotubes connected by organometallic linkages. These linkages are designed to increase electronic communication between adjacent nanotubes and, thus, the overall resting conductivity. Select volatile compounds are expected to disrupt these organometallic centers via oxidation, reduction, or ligand substitution. The overall sensor should be more sensitive and selective than purely organic-functionalized or metal-functionalized nanotube networks. The ultimate goal of this work is to develop sensitive, portable, and always-on sensors to detect environmental VOC exposure at levels well below toxicity thresholds and to monitor breath vapor VOCs of patients to aid in diagnosis of diseases such as lung cancer.

 描述（由申请人提供）：该提案描述了用于检测一氧化碳、甲醛、甲醇、乙醇、丙酮和氢气的便携式、经济有效且节能的化学传感器的开发，感测这些挥发性化合物既可以预防也可以预防和预防。诊断健康问题。一些疾病是由于接触低水平的挥发性化合物造成的，例如，甲醛这种常见的室内污染物与哮喘发病率有关。例如，一组包含个人健康诊断信息的分子可以通过人的呼吸气味来检测肺癌，这种传感器可以部署在始终在线的网络阵列中。防止接触有害化学物质；便携性可以将气体传感器的应用扩展到监测个人健康，这可能会彻底改变医疗保健领域的呼吸蒸气分析虽然气相色谱法是准确识别痕量化合物的黄金标准，但仪器仪表。成本高昂，需要专门培训才能操作。其他检测挥发物的平台（燃料电池、红外光谱等）可能操作起来更简单，但面临灵敏度、选择性、成本和功耗等问题，为了解决这些问题，人们探索了“电子鼻”策略。特别是，Swager 和同事研究了基于功能化碳纳米管网络的电阻传感器，这可能会导致廉价、低功耗、坚固且便携式的化学物质的出现。传感器。进一步改进这些传感器的灵敏度和选择性可能会导致商业上可行的设备。 这项研究的目标是建立一个通过有机金属键连接的单壁碳纳米管网络，这些连接旨在增加相邻纳米管之间的电子通信，因此，选择的挥发性化合物预计会破坏这些有机金属。整个传感器应该比纯有机功能化或金属功能化的纳米管网络更加灵敏和选择性。始终开启的传感器可检测远低于毒性阈值的环境 VOC 暴露水平，并监测患者呼吸蒸气 VOC，以帮助诊断肺癌等疾病。