Role of Childhood Cumulative Risk in Substance Misuse and Co-occurring Problems

童年累积风险在药物滥用和并发问题中的作用

• 批准号: 9064121
• 负责人: W Alex Mason
• 金额: $ 24.1万
• 依托单位: FATHER FLANAGAN'S BOYS' HOME
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9064121
• 关键词: Address; Adolescence; Adolescent; Adolescent and Young Adult; Alcohol or Other Drugs use; Applications Grants; Belief; Birth; Buffers; Childhood; Cohort Studies; Comorbidity; Data; Data Analyses; Data Set; Data Sources; Development; Developmental Process; Finland; Gender; Health; Health Benefit; Impairment; Intervention; Knowledge; Left; Measures; Mediating; Mediator of activation protein; Mental Depression; Mission; Modeling; Morbidity - disease rate; National Institute of Drug Abuse; Nature; Outcome; Parents; Pathway interactions; Process; Provider; Public Health; Research; Research Personnel; Rewards; Risk; Risk Factors; Role; Sample Size; Sampling; Services; Social Development; Source; Specific qualifier value; Testing; Time; Translating; Translations; United States National Institutes of Health; Universities; Youth; anti social; base; cohort; cost effective; data registry; early onset; emerging adult; experience; gender difference; high risk; improved outcome; informant; innovation; longitudinal design; mortality; population survey; prenatal; programs; prospective; resilience; selective prevention; skills; social; socioeconomic disadvantage; substance misuse; substance misuse prevention; teacher; therapy design

DESCRIPTION (provided by applicant): Vulnerability for substance misuse is highest among youth who experience multiple contextual risks, such as birth-related risks and socioeconomic disadvantage, during early development. Indeed, cumulative risk, defined as the number of contextual risk factors independent of the presence or absence of any particular risk, is a robust predictor of adolescent and young adult substance misuse. However, there are significant gaps in knowledge about the associations of cumulative contextual risk with substance misuse. Cumulative risk often has been studied as a static phenomenon, therefore the degree to which such risk accumulates both within and across time is unknown. Moreover, research in the cumulative risk tradition typically has examined substance misuse as a singular outcome, yet substance misuse often co-occurs with externalizing and internalizing problems. Importantly, potential mediating mechanisms and moderating influences infrequently have been considered in analyses of cumulative risk effects on substance misuse, and gender moderation rarely has been tested. Substance misuse is a prevalent public health concern, and substance misuse comorbidity is associated with heightened impairment compared to singular problems; thus, additional research is needed. The current grant application helps address these gaps by proposing to study cumulative contextual risk both within and across time during early development in relation to substance misuse and co- occurring externalizing and internalizing problems in adolescence and early adulthood (Aim 1). Social developmental mediators will be examined as intervening mechanisms (Aim 2a) and tests of social developmental moderators hypothesized to buffer risk (Aim 2b) will be conducted using existing longitudinal data from the 1986 Northern Finland Birth Cohort Study (NFBCS). The NFBCS is a large-scale birth cohort study with multi-informant (parent, teacher, adolescent), multi-source (surveys, population registries) data collected on a sample of 9,432 youth followed from the prenatal period to the 20s. Guided by the social development model (SDM), the central hypotheses are that there will be positive associations of cumulative risk with adolescent and young adult substance misuse and co-occurring problems, and that those associations will be mediated through SDM risk processes; SDM protective factors will serve as buffering moderators. Gender differences also will be explored. This application is highly innovative. The NFBCS is a unique, large-scale birth cohort study with an exceptionally broad range of biopsychological and social contextual assessments ideal for studying general risk and resilience processes. Aims of the proposed study will be accomplished by an interdisciplinary team of investigators from both university and service provider settings to facilitate translation of findings into practice. Study findings hold promise for helping to promote resilience in the face of risk among vulnerable youth by elucidating potentially malleable mediators and moderators to target in selective preventive interventions.

描述（由申请人提供）：在早期发展期间，遇到多种背景风险的年轻人中，滥用物质滥用的脆弱性是最高的，例如与出生有关的风险和社会经济劣势。的确，累积风险被定义为无关的上下文风险因素，而不是存在或不存在任何特定风险，是青少年和年轻成人物质滥用的强大预测指标。但是，关于累积上下文风险与滥用物质的关联的知识存在很大的差距。累积风险通常被研究为一种静态现象，因此，这种风险在跨时间内和跨时间积累的程度尚不清楚。此外，对累积风险传统的研究通常将滥用物质滥用视为一种奇异结果，但滥用物质通常与外在化和内在化问题共同占领。重要的是，在分析累积风险对药物滥用的累积影响时，很少考虑了潜在的介导机制和调节影响，并且很少对性别节制进行测试。滥用药物是一个普遍的公共卫生问题，与奇异问题相比，滥用毒品的合并症与增强的障碍有关。因此，需要其他研究。当前的赠款申请通过提议在早期开发过程中和整个时间内和整个时间内的累积上下文风险来帮助解决这些差距，这与滥用物质的滥用以及在青春期和成年初期的外部化和内在化问题有关（AIM 1）。将使用1986年北芬兰北部出生队列研究（NFBCS）的现有纵向数据进行，将研究社会发展调解人作为中间机制（AIM 2A）和假设为缓冲风险进行的社会发展主持人测试（AIM 2B）。 NFBC是一项大规模的出生队列研究，具有多种形式（父母，教师，青少年），多源（调查，人口注册表）的数据，该数据收集了9,432名青年样本，然后从产前期到20年代。在社会发展模型（SDM）的指导下，中央假设是，累积风险与青少年和年轻的成人物质滥用和同时发生的问题将存在积极的联系，并且这些关联将通过SDM风险过程进行介导； SDM保护因素将作为缓冲主持人。还将探讨性别差异。该应用程序具有很高的创新性。 NFBCS是一项独特的大规模出生队列研究，其生物心理学和社会环境评估非常广泛，非常适合研究一般风险和弹性过程。拟议研究的目的将由大学和服务提供商设置的研究人员组成的跨学科团队来促进研究结果将其转化为实践。研究结果有望通过阐明潜在的可延展的介体和主持人来瞄准选择性预防性干预措施，从而有助于在弱势青年面临风险中促进韧性。

项目成果

Childhood cumulative contextual risk and depression diagnosis among young adults: The mediating roles of adolescent alcohol use and perceived social support.

年轻人的童年累积背景风险和抑郁症诊断：青少年饮酒和感知社会支持的中介作用。

• DOI: 10.1016/j.adolescence.2017.07.008
• 发表时间: 2017
• 期刊: Journal of adolescence
• 影响因子: 3.8
• 作者: Patwardhan,Irina;Mason,WAlex;Savolainen,Jukka;Chmelka,MaryB;Miettunen,Jouko;Järvelin,Marjo-Riitta
• 通讯作者: Järvelin,Marjo-Riitta

The path from childhood behavioural disorders to felony offending: Investigating the role of adolescent drinking, peer marginalisation and school failure.

从儿童行为障碍到重罪的路径：调查青少年饮酒、同伴边缘化和学业失败的作用。

• DOI: 10.1002/cbm.1931
• 发表时间: 2015
• 期刊: Criminal behaviour and mental health : CBMH
• 作者: Savolainen,Jukka;Mason,WAlex;Bolen,JonathanD;Chmelka,MaryB;Hurtig,Tuula;Ebeling,Hanna;Nordström,Tanja;Taanila,Anja
• 通讯作者: Taanila,Anja

Does Educational Marginalization Mediate the Path from Childhood Cumulative Risk to Criminal Offending?

教育边缘化是否介导了从童年累积风险到刑事犯罪的路径？

• DOI: 10.1007/s40865-017-0062-9
• 发表时间: 2017
• 期刊: Journal of developmental and life-course criminology
• 影响因子: 1.9
• 作者: Solomon,StarrJ;Savolainen,Jukka;Mason,WAlex;Miettunen,Jouko;January,Stacy-AnnA;Järvelin,Marjo-Riitta
• 通讯作者: Järvelin,Marjo-Riitta

Associations of Cumulative Family Risk With Academic Performance and Substance Involvement: Tests of Moderation by Child Reading Engagement.

累积家庭风险与学业成绩和物质参与的关联：儿童阅读参与度的调节测试。

• DOI: 10.1080/10826084.2019.1608248
• 发表时间: 2019
• 期刊: Substance use & misuse
• 影响因子: 2
• 作者: Mason,WAlex;Chmelka,MaryB;Patwardhan,Irina;January,Stacy-AnnA;Fleming,CharlesB;Savolainen,Jukka;Miettunen,Jouko;Järvelin,Marjo-Riitta
• 通讯作者: Järvelin,Marjo-Riitta