CRITICAL TRANSLATIONAL STUDIES IN PEDIATRIC NEPHROLOGY

儿科肾脏病学的关键转化研究

• 批准号: 9143094
• 负责人: PRASAD DEVARAJAN
• 金额: $ 73.08万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-21 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9143094
• 关键词: Acute Renal Failure with Renal Papillary Necrosis; Address; Area; Basic Science; Biological Markers; Childhood; Clinical; Clinical Research; Collaborations; Disease; Fellowship; Focal Segmental Glomerulosclerosis; Fostering; Funding; Future; Gene Expression; Goals; Individual; Injury; Institution; Kidney; Kidney Diseases; Leadership; Lupus Nephritis; Medical center; Medicine; Mission; Nephrology; Outcome; Pediatric Hospitals; Pilot Projects; Proteomics; Public Health; Research Personnel; Research Project Grants; Resources; Science; Training Programs; Translational Research; United States National Institutes of Health; base; bench to bedside; innovation; interdisciplinary approach; multidisciplinary; novel; response; success; translational study

In response to RFA-DK-11-009, our overall goal is to create a Pediatric Center of Excellence in Nephrology at Cincinnati Children's Hospital Medical Center (CCHMC PGEN), to support basic, translational, and clinical research on critical pediatric kidney diseases that have major unmet needs. The overarching theme is to conduct innovative and high-impact bench-to-bedside studies on three critical but underserved pediatric kidney diseases. Our three areas of focus include acute kidney injury, focal segmental glomerulosclerosis, and lupus nephritis, already developed as areas of multidisciplinary expertise at our institution. The urgent need will be addressed by three individual research projects as well as by the three Biomedical Cores, all proposed by outstanding funded investigators with a track record of successful multidisciplinary collaborative efforts in the focu areas. The two novel exploratory pilot studies proposed by exceptional and promising young investigators will form the basis for their future investigator-initiated applications to study acue kidney injury. The specific aims include: (1) to attract outstanding scientific expertise into the study of critical but underserved pediatric kidney diseases; (2) to foster multidisciplinary approaches to the study of critical but underserved pediatric kidney diseases within our focus areas at the basic, translational, and clinical levels; (3) To provide high-resource Gene Expression, Proteomics, and Biomarker Cores to support the study of pediatric kidney diseases locally, regionally, and nationally; and (4) to support novel exploratory pilot studies that will form the basis for future investigator-initiated applications t study critical but underserved pediatric kidney diseases. Evidence for strong support from institutional leadership is provided. Added strengths include the CCHMC Pediatric Nephrology Division, with a proven track record of excellence and collaboration in the study of the three focus areas. Active support and collaboration from the institutional CTSA and from a large number of divisions that are involved in multidisciplinary collaborative efforts in the three focus areas of study provide the extended resources for success. The proposal also comes with active support and collaboration from our NIH funded T32 Fellowship Training Program.

为了响应RFA-DK-11-009，我们的总体目标是在辛辛那提儿童医院医疗中心（CCHMC PGEN）建立儿科肾脏科学卓越中心，以支持有关具有主要未受满足需求的重要儿科肾脏疾病的基本，翻译和临床研究。总体主题是对三种关键但服务不足的小儿肾脏疾病进行创新且高影响力的基准研究。我们的三个重点领域包括急性肾脏损伤，局灶性节段性肾小球硬化和狼疮性肾炎，该领域已经发展为我们机构多学科专业知识的领域。三个个人研究项目以及三个生物医学核心将解决迫切的需求，所有这些核心都提出了杰出的资助研究人员提出的，并在焦点领域取得了成功的多学科合作努力的记录。杰出和有前途的年轻研究人员提出的两项新型探索性试验研究将为他们未来研究者发起的研究肾脏肾脏损伤的应用构成基础。具体目的包括：（1）吸引杰出的科学专业知识来研究关键但服务不足的小儿肾脏疾病； （2）促进多学科方法来研究我们重点区域内的关键但服务不足的小儿肾脏疾病，这是基本，转化和临床水平的； （3）提供高源基因表达，蛋白质组学和生物标志物核心，以支持对本地，区域和全国范围内的小儿肾脏疾病的研究； （4）支持新的探索性试验研究，这将成为未来研究者发起的应用的基础，研究关键但服务不足的小儿肾脏疾病。提供了机构领导的大力支持的证据。增加的优势包括CCHMC儿科肾脏科，在研究三个焦点领域的研究中具有卓越的卓越和协作记录。来自机构CTSA的积极支持和协作以及在三个焦点研究领域中涉及多学科合作努力的大量部门提供了扩展的成功资源。该提案还带来了我们NIH资助的T32奖学金培训计划的积极支持和协作。