DATA COORDINATING CENTER FOR THE START-UP AND PREPARATION OF THE TRANSGENERATIONAL STUDY

跨代研究启动和准备的数据协调中心

• 批准号: 9360167
• 负责人: ROBERT GORE-LANGTON
• 金额: $ 7.49万
• 依托单位: THE EMMES COMPANY, LLC
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-11 至 2017-01-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9360167
• 关键词: Adolescence; Adolescent Behavior; Adult; Affect; Age; Anatomy; Animals; Atherosclerosis; Behavioral; Bioinformatics; Biological Markers; Biometry; Blood Vessels; Body mass index; Cardiovascular system; Childhood; Cohort Studies; Computer software; Data; Data Collection; Data Coordinating Center; Development; Epidemiology; Exposure to; Fetal Structures; Genetic; Gestational Diabetes; Health; Health behavior; Human; Hyperglycemia; Impact evaluation; Intramural Research; Lead; Life; Measures; Mediating; Metabolic; Mission; Molecular; Mothers; National Institute of Child Health and Human Development; Nitroglycerin; Non obese; Obesity; Overweight; Participant; Perinatal Exposure; Physiology; Pregnancy; Preparation; Public Health; Recruitment Activity; Reproduction; Reproductive Health; Research; Research Personnel; Resolution; Siblings; Systemic blood pressure; Teratogens; Testing; Time; Ultrasonography; Woman; adolescent health; arterial stiffness; blood lipid; brachial artery; cardiovascular health; cohort; design; disorder risk; fetal; in utero; interest; metabolomics; named group; non-genetic; offspring; population health; pregnant; prospective; reactive hyperemia; reproductive; reproductive development; response

The Division of Intramural Population Health Research (DIPHR) at the Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) designs and conducts original epidemiological, behavioral, and biostatistical research encompassing several research domains such as human reproduction and development, pregnancy and related complications, pediatric and adolescent health and behaviors, and methodologic research relevant for our mission. The Division comprises three intramural research branches Epidemiology, Biostatistics & Bioinformatics, and Health Behavior, and its mission is to design and implement original research with the potential for high impact findings for public health and its special populations. Accumulating evidence from animal and human studies suggests that adverse intrauterine exposures may lead to permanent fetal adaptions in anatomy and physiology, which may be beneficial for short term fetal survival, but result in an altered long-term risk of disease later in life. Maternal obesity and gestational diabetes mellitus (GDM) are exposures of particular interest given that a very high proportion of women (~25%) are obese when becoming pregnant. Moreover, hyperglycemia in pregnancy as exemplified in GDM has long been regarded as a teratogen which affects fetal structure, function, and development and has long-term adverse impacts on the offspring. Data from mechanistic studies indicates that fetal exposure to obesity and/or hyperglycemia may lead to long-term metabolic and vascular function alteration. Thus, investigators at the NICHD have designed and will implement a cohort study of offspring of an existing cohort of mothers using both retrospective and prospective data collection to evaluate impacts of GDM and obesity on the metabolic, vascular, and reproductive health of the offspring, their determinants and the underlying molecular mechanisms

Eunice Kennedy Shriver国家儿童健康与人类发展研究所（NICHD）设计并进行了原始的流行病学，行为和生物统计学研究，涵盖了几个研究领域，诸如人类繁殖以及人类繁殖，妊娠和相关的复杂性，儿童和崇拜健康和行为方面的研究。 该部门包括三个壁内研究部门的流行病学，生物统计学和生物信息学和健康行为，其使命是设计和实施原始研究，并有可能为公共卫生及其特殊人群提供高影响力发现。 从动物和人类研究中积累的证据表明，宫内不良暴露可能会导致解剖学和生理学中的永久性胎儿适应，这可能对短期胎儿存活有益，但会导致长期生命后期的长期风险。 鉴于怀孕时，女性比例很高（约25％）是肥胖的，孕妇肥胖和妊娠糖尿病是特别关注的暴露。 此外，长期以来，在GDM中示例的怀孕高血糖一直被认为是影响胎儿结构，功能和发育的致病，并且对后代有长期不利影响。 机械研究的数据表明，胎儿暴露于肥胖和/或高血糖可能会导致长期代谢和血管功能改变。 因此，NICHD的研究人员已经设计并将使用回顾性和前瞻性数据收集对现有母亲的后代进行研究，以评估GDM和肥胖对代谢，血管，血管和生殖健康的影响