2/2 - Familial Early-Onset Suicide Attempt Biomarkers

2/2 - 家族性早发性自杀企图生物标志物

基本信息

批准号：
9131809
负责人：
Joseph John Mann
金额：
$ 42.15万
依托单位：
NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-08-18 至 2020-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9131809
关键词：
Adult Children Age Amygdaloid structure Attention Autoreceptors Binding Biological Biological Assay Biological Markers Brain Brain Stem Clinical assessments Cognition Data Disease susceptibility Distress Dorsal Family history of Feeling suicidal Funding Health Hippocampus (Brain)Hydrocortisone Image Image Analysis Individual Lateral MRI Scans Major Depressive Disorder Measures Medial Memory Mental disorders Midbrain structure Mood Disorders New York Onset of illness Parents Pathway interactions Performance Pharmaceutical Preparations Phenotype Positron-Emission Tomography Prefrontal Cortex Prevention Preventive Intervention Protocols documentation Reactive depression Recording of previous events Recruitment Activity Research Design Risk Serotonin Severities Site Stress Tests Suicide Suicide attempt Task Performances Testing Trier Social Stress Test Universities Volunteer Group Work attentional bias base biological adaptation to stress cognitive testing comparison group data management depressed patient early onset endophenotype follow-up healthy volunteer high risk mood regulation offspring performance site proband raphe nuclei resilience response single episode major depressive disorder statistics suicidal behavior suicidal patient suicide rate trait

项目摘要

DESCRIPTION (provided by applicant): The suicide rate in the USA is the same as 60 years ago. Better prevention needs more data on risk and resilience biomarkers. We seek to determine both resilience and vulnerability potential endophenotypes for suicide attempts in major depressive disorder (MDD). Both endophenotypes may aid estimation of risk and provide new targets for prevention intervention. The study design compares healthy volunteers (Group 1) with medication-free adult offspring of a parent with MDD and suicidal behavior who are through the age of risk and can thus be divided into a resilient group (Group 4), a group with a diathesis for MDD (Group 2) and one with diatheses for MDD and suicide attempts (Group 3). Comparison of Groups 2 and 3 indicates the diathesis for suicidal behavior. Comparison of Group 1 and 4 indicates the resilience phenotype. Comparison of Group 1 and Group 2 indicates the diathesis for MDD. This study is a new direction based on our almost complete longitudinal two-site follow-up study (PI, J. John Mann, MD, MH056390, Columbia University, NYC and PI, David Brent, MD, MH056612, UPMC, Pittsburgh) of 701 offspring of 334 probands with mood disorder entitled: "Familial Pathways to Early-Onset Suicide Attempts" that has sought to identify mechanisms by which suicidal behavior risk is transmitted from parent to offspring. Our findings on risk traits in the domains of cognition, mood regulation and stress responses, together with a new domain of brain PET imaging of the 5-HT1A autoreceptor that regulates serotonin release, will focus the search for resilience and vulnerability phenotypes. This study will involve the same two performance sites as the current funded application that ends January 2015. The teams have worked together for >15 years and both teams have conducted PET studies of depressed and suicidal patients. We will recruit eligible offspring from the old study and recruit new offspring as needed for the four groups. Both sites will perform clinical and cognitive assessments, stress tests and PET/MRI scans using identical protocols. The New York site will be the data management site including image analyses and statistics, and assay cortisols.

描述（由适用提供）：美国的自杀率与60年前相同。更好的预防需要更多有关风险和弹性生物标志物的数据。我们试图确定重度抑郁症（MDD）自杀尝试的弹性和脆弱性潜在的内表型。两种内型型都可以帮助估计风险，并为预防干预提供新的目标。该研究设计将健康的志愿者（第1组）与无药物的成人后代进行了比较，该父母具有MDD和自杀行为，他们处于风险时代，因此可以分为有弹性的组（第4组），该组具有MDD（2组）和MDD和MDD和自动化自动化和自动化识别（第2组）的识别（第2组）的群体。第2组和第3组的比较表明了自杀行为的素质。第1组和第4组的比较表示弹性表型。第1组和第2组的比较表明MDD的素质。 This study is a new direction based on our almost complete longitudinal two-site follow-up study (PI, J. John Mann, MD, MH056390, Columbia University, NYC and PI, David Brent, MD, MH056612, UPMC, Pittsburgh) of 701 offspring of 334 problems with mood disorder entitled: "Familial Pathways to Early-Onset Suicide Attempts" that has被认为是为了识别自杀行为风险从父母传播到后代的机制。我们在认知，情绪调节和压力反应领域的风险特征的发现，以及调节5- ht1a自身受体的脑PET成像的新领域，该领域调节血清素释放，将集中于寻找弹性和脆弱性表型。这项研究将涉及与2015年1月结束的当前资助应用程序相同的两个性能站点。这些团队已经合作了15年，并且两支球队都对沮丧和自杀的患者进行了宠物研究。我们将从旧研究中招募有资格的后代，并根据需要的四组招募新的后代。两个地点将使用相同的方案进行临床和认知评估，应力测试以及PET/MRI扫描。纽约站点将是数据管理网站，包括图像分析和统计信息以及测定皮质醇。