Drug Dependence Clinical Research Program

药物依赖性临床研究计划

基本信息

批准号：
8933724
负责人：
NEAL L BENOWITZ
金额：
$ 75.26万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
起止时间：
1999-09-01 至 2020-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8933724
关键词：
Analytical Chemistry Area Biological Markers Cancer Grant Supplements (P30)Cardiology Cessation of life Chemistry Clinic Clinical Pharmacology Clinical Psychology Clinical Research Consultations Country Data Analyses Development Discipline Drug Addiction Drug Kinetics Drug abuse Drug usage Environmental Tobacco Smoke Faculty Funding Future Health Human Individual Institution Internal Medicine Laboratories Measures Mentors Methods Modality National Institute of Drug Abuse Pediatrics Pharmaceutical Preparations Poison Postdoctoral Fellow Prevention program Psychiatry Psychotropic Drugs Public Policy Pulmonology Regulation Request for Applications Research Research Design Research Infrastructure Research Personnel Research Priority Research Project Grants Research Support Research Training Resources Synthesis Chemistry Tobacco Tobacco Dependence Tobacco smoking addiction analytical method career development cost cost effective design drug abuse chemotherapy drug of abuse effective therapy experience instrument member method development non-smoker premature programs public health relevance public health research ranpirnase treatment strategy

项目摘要

DESCRIPTION (provided by applicant): This Core Support Center Grant (P30) application requests continued support for an analytical and synthetic chemistry laboratory and administrative core infrastructure. The currently funded constituent projects continue research programs with human laboratory and treatment clinic studies of the clinical pharmacology of abused drugs, pharmacotherapies and other treatment strategies to treat drug abuse and addictions. Disciplines represented by the participating projects and investigators include psychiatry, clinical psychology, general internal medicine and clinical pharmacology, cardiology, pulmonary medicine, pediatrics, and chemistry. Currently, the supported projects involve primarily the problems associated with tobacco addiction, but we are prepared to support studies of other abused drugs as well. Our aims are: (1) To provide a state-of-the-art, well equipped and staffed, analytical and synthetic chemistry laboratory resource for the participating projects of drug abuse researchers at UCSF and at other institutions. (2) To provide consultation regarding optimal study design and data analysis strategies, particularly regarding pharmacokinetic analysis for participating projects. The overall objective is to provide sophisticated analytical laboratory resources responsive to the needs of individual constituent scientific projects as these projects change and evolve. This facility is a cost-effective shared laboratory resource that enhances research possibilities to further our understanding of human psychoactive drug use, abuse and addiction, its health consequences and its treatment.

描述（由应用程序提供）：此核心支持中心赠款（P30）申请要求继续支持分析和合成化学实验室和行政核心基础设施。当前资助的组成项目继续研究研究计划，其中包括滥用药物，药物治疗和其他治疗药物滥用和成瘾的治疗策略的人类实验室和治疗诊所研究。参与项目和研究人员代表的学科包括精神病学，临床心理学，通用内科和临床药理学，心脏病学，肺医学，儿科和化学。目前，受支持的项目涉及与烟草成瘾相关的问题，但我们也准备支持对其他滥用药物的研究。我们的目的是：（1）为UCSF和其他机构提供最先进的，设备齐全的，分析和合成化学实验室资源，为参与药物滥用研究人员的参与项目。（2）提供有关最佳研究设计和数据分析策略的咨询，特别是有关参与项目的药代动力学分析。总体目标是随着这些项目的变化和进化，提供了响应各个组成科学项目需求的复杂分析实验室资源。该设施是一种具有成本效益的共享实验室资源，可增强研究潜力，以进一步了解人类的精神药物使用，滥用和成瘾，其健康后果及其治疗。